Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite‐induced cholangiocarcinoma in humans

Sujit S. Nair, Anitha Bommana, Suresh B. Pakala, Kazufumi Ohshiro, Amanda J. Lyon, Sutas Suttiprapa, Maria V. Periago, Thewarach Laha, Peter J. Hotez, Jeffrey M. Bethony, Banchob Sripa, Paul J.

SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism

Weiwei Tao, Siyu Chen, Guangsen Shi, Jinhu Guo, Ying Xu, Chang Liu – 2 July 2011 – Many aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism, are under precise control by the mammalian circadian clock. However, the molecular mechanism for coordinate integration of the circadian clock and various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin‐remodeling complex subunit, is rhythmically expressed in the liver of mice.

The assessment of serum hepatitis C virus RNA 12 weeks after the end of treatment using TaqMan polymerase chain reaction is less relevant than after 24 weeks for predicting sustained virological response

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

Kristina M. Mueller, Jan‐Wilhelm Kornfeld, Katrin Friedbichler, Leander Blaas, Gerda Egger, Harald Esterbauer, Peter Hasselblatt, Michaela Schlederer, Susanne Haindl, Kay‐Uwe Wagner, David Engblom, Guenter Haemmerle, Dagmar Kratky, Veronika Sexl, Lukas Kenner, Andrey V. Kozlov, Luigi Terracciano, Rudolf Zechner, Guenther Schuetz, Emilio Casanova, J. Andrew Pospisilik, Markus H.

PUMA–mediated apoptosis drives chemical hepatocarcinogenesis in mice

Wei Qiu, Xinwei Wang, Brian Leibowitz, Wancai Yang, Lin Zhang, Jian Yu – 2 July 2011 – Hepatocyte death and proliferation contribute to hepatocellular carcinoma development after carcinogen exposure or chronic liver inflammation. However, the role and the molecular targets of hepatocyte death in relation to compensatory proliferation have not been fully characterized.

Changes in hepatitis A and B vaccination rates in adult patients with chronic liver diseases and diabetes in the U.S. population

Zobair M. Younossi, Maria Stepanova – 2 July 2011 – Professional societies recommend hepatitis A and hepatitis B immunization for individuals with chronic liver disease (CLD), but the degree of implementation is unknown. Data were obtained from the National Health and Nutrition Examination Surveys (NHANES) conducted in 1999‐2008.

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