Emma A. Kruglov, Samir Gautam, Mateus T. Guerra, Michael H. Nathanson – 11 July 2011 – Bile salt secretion is mediated primarily by the bile salt export pump (Bsep), a transporter on the canalicular membrane of the hepatocyte. However, little is known about the short‐term regulation of Bsep activity. Ca2+ regulates targeting and insertion of transporters in many cell systems, and Ca2+ release near the canalicular membrane is mediated by the type II inositol 1,4,5‐trisphosphate receptor (InsP3R2), so we investigated the possible role of InsP3R2 in modulating Bsep activity.

K. Raj Prasad, Richard S. Young, Patrizia Burra, Shu‐Sen Zheng, Vincenzo Mazzaferro, Duk Bog Moon, Richard B. Freeman – 11 July 2011

Ian Webzell, David Ball, James Bell, Roy A. Sherwood, Andrew Marsh, John G. O'Grady, Nigel D. Heaton – 8 July 2011 – Toxicological urinalysis is a highly sensitive and specific test that detects recent substance use. It has been established for substance misuse treatment but has not been routinely used at liver transplantation (LT) centers. Patients with a history of substance misuse are required to be abstinent from alcohol and illicit drugs before they are listed for LT.

Hsin‐Yun Sun, Thomas V. Cacciarelli, Marilyn M. Wagener, Nina Singh – 8 July 2011 – Whether the duration of renal replacement therapy (RRT) after liver transplantation influences the rate and types of bacterial infections is not known. In this study, 47 of 299 consecutive liver transplant recipients (16%) required posttransplant RRT. The incidence of bacterial infections was higher in the RRT group versus the non‐RRT group (8.84 versus 1.38 per 1000 patient days, P < 0.001).

Beat Müllhaupt, Francois Durand, Tanja Roskams, Philipp Dutkowski, Markus Heim – 8 July 2011

Seth A. Waits, Brandon M. Wojcik, Shijie Cai, Amit K. Mathur, Michael J. Englesbe – 8 July 2011 – The effect of occlusive portal vein thrombosis (PVT) on the mortality of pediatric liver transplant candidates and recipients is poorly defined. Using standard multivariate techniques, we studied the relationship between PVT and waiting‐list and posttransplant survival rates with data from the Scientific Registry of Transplant Recipients (September 2001 to December 2007). In all, 5087 liver transplant candidates and 3630 liver transplant recipients were evaluated during the period.

Eric Levesque, Emir Hoti, Meriem Khalfallah, Chady Salloum, Luana Ricca, Eric Vibert, Daniel Azoulay – 8 July 2011 – Several donor and graft characteristics are associated with higher failure rates for deceased donor liver transplantation (LT). The influence of reversible cardiac arrest in the donor on these failure rates is unclear because of scarce and inconsistent data. The aim of this study was to determine whether reversible cardiac arrest in the donor could affect the early postoperative outcome of LT.

Jeong Min Lee, Franco Trevisani, Valerie Vilgrain, Christoph Wald – 7 July 2011

Vishakha S. Bhave, Shirish Paranjpe, William C. Bowen, Shashikiran Donthamsetty, Aaron W. Bell, Jaspal S. Khillan, George K. Michalopoulos – 7 July 2011 – Reprogramming factors have been used to induce pluripotent stem cells as an alternative to somatic cell nuclear transfer technology in studies targeting disease models and regenerative medicine. The neuronal repressor RE‐1 silencing transcription factor (REST) maintains self‐renewal and pluripotency in mouse embryonic stem cells by maintaining the expression of Oct3/4, Nanog, and cMyc.

Cheng‐Maw Ho, Po‐Huang Lee, Rey‐Heng Hu – 6 July 2011