Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans

Fu Yang, Ling Zhang, Xi‐song Huo, Ji‐hang Yuan, Dan Xu, Sheng‐xian Yuan, Nan Zhu, Wei‐ping Zhou, Guang‐shun Yang, Yu‐zhao Wang, Jing‐li Shang, Chun‐fang Gao, Feng‐rui Zhang, Fang Wang, Shu‐han Sun – 18 July 2011 – In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) remain largely unknown.

Hepatic steatosis at 1 year is an additional predictor of subsequent fibrosis severity in liver transplant recipients with recurrent hepatitis C virus

Danielle Brandman, Andrea Pingitore, Jennifer C. Lai, John P. Roberts, Linda Ferrell, Nathan M. Bass, Norah A. Terrault – 18 July 2011 – Recurrent hepatitis C virus (HCV) is the most common cause of graft loss for HCV‐infected recipients of liver transplantation (LT). Diabetes mellitus (DM) has been associated with increased rates of fibrosis progression, but whether steatosis affects post‐LT outcomes independently of DM is unclear.

Biliary complications after living donor liver transplantation

Shao Fa Wang, Zhi Yong Huang, Xiao Ping Chen – 14 July 2011 – Biliary complications occur more frequently after living donor liver transplantation (LDLT) versus deceased donor liver transplantation, and they remain the most common and intractable problems after LDLT. The anatomical limitations of multiple tiny bile ducts and the differential blood supplies of the graft ducts may be significant factors in the pathophysiological mechanisms of biliary complications in patients undergoing LDLT.

Renal function in patients undergoing transplantation for nonalcoholic steatohepatitis cirrhosis: Time to reconsider immunosuppression regimens?

Diarmaid D. Houlihan, Matthew J. Armstrong, Yana Davidov, James Hodson, Peter Nightingale, Ian A. Rowe, Sue Paris, Bridget K. Gunson, Simon B. Bramhall, David J. Mutimer, James M. Neuberger, Philip N. Newsome – 14 July 2011 – Nonalcoholic fatty liver disease is an independent risk factor for chronic kidney injury (CKI), yet the impact of liver transplantation (LT) on renal function in this at‐risk group is not known. We compared the post‐LT renal function of patients with nonalcoholic steatohepatitis (NASH) and a matched comparison group.

Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus

Mustafa Ates, Abuzer Dirican, Dincer Ozgor, Cemalettin Aydin, Burak Isik, Cengiz Ara, Mehmet Yilmaz, M. Ayse Selimoglu, Cuneyt Kayaalp, Sezai Yilmaz – 14 July 2011 – Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus, either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to acute liver failure (ALF). We present the outcomes of 10 children who ingested fireworks containing yellow phosphorus.

Anemia is not predictive of sustained virological response in liver transplant recipients with hepatitis C virus who are treated with pegylated interferon and ribavirin

Michela Giusto, Maria Rodriguez, Laia Navarro, Angel Rubin, Victoria Aguilera, Fernando San‐Juan, Cecilia Ortiz, Rafael López‐Andujar, Martín Prieto, Marina Berenguer – 14 July 2011 – In the immunocompetent setting, antiviral therapy–related anemia has recently been shown to be associated with a sustained virological response (SVR). Our goal was to assess whether this is also true for liver transplantation (LT).

Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes

Emma A. Kruglov, Samir Gautam, Mateus T. Guerra, Michael H. Nathanson – 11 July 2011 – Bile salt secretion is mediated primarily by the bile salt export pump (Bsep), a transporter on the canalicular membrane of the hepatocyte. However, little is known about the short‐term regulation of Bsep activity. Ca2+ regulates targeting and insertion of transporters in many cell systems, and Ca2+ release near the canalicular membrane is mediated by the type II inositol 1,4,5‐trisphosphate receptor (InsP3R2), so we investigated the possible role of InsP3R2 in modulating Bsep activity.

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