Gankyrin‐mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells

Wen Sun, Jin Ding, Kun Wu, Bei‐Fang Ning, Wen Wen, Han‐Yong Sun, Tao Han, Lei Huang, Li‐Wei Dong, Wen Yang, Xing Deng, Zhong Li, Meng‐Chao Wu, Gen‐Sheng Feng, Wei‐Fen Xie, Hong‐Yang Wang – 6 July 2011 – Gankyrin is a critical oncoprotein overexpressed in human hepatocellular carcinoma (HCC). However, the mechanism underlying gankyrin‐mediated hepatocarcinogenesis remains elusive. Herein, we provide evidence that gankyrin expression was progressively elevated in liver fibrosis, cirrhosis, and HCC.

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

Masanobu Tsuda, Yoko M. Ambrosini, Weici Zhang, Guo‐Xiang Yang, Yugo Ando, Guanghua Rong, Koichi Tsuneyama, Kosuke Sumida, Shinji Shimoda, Christopher L. Bowlus, Patrick S.C. Leung, Xiao‐Song He, Ross L. Coppel, Aftab A. Ansari, Zhe‐Xiong Lian, M. Eric Gershwin – 6 July 2011 – In primary biliary cirrhosis (PBC), patients develop a multilineage response to a highly restricted peptide of the E2 component of pyruvate dehydrogenase (PDC‐E2) involving autoantibody and autoreactive cluster of differentiation (CD)4+ and CD8+ T‐cell responses.

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

Alexandre Louvet, Fatima Teixeira‐Clerc, Marie‐Noële Chobert, Vanessa Deveaux, Catherine Pavoine, Andreas Zimmer, Françoise Pecker, Ariane Mallat, Sophie Lotersztajn – 6 July 2011 – Activation of Kupffer cells plays a central role in the pathogenesis of alcoholic liver disease. Because cannabinoid CB2 receptors (CB2) display potent anti‐inflammatory properties, we investigated their role in the pathogenesis of alcoholic liver disease, focusing on the impact of CB2 on Kupffer cell polarization and the consequences on liver steatosis.

Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite‐induced cholangiocarcinoma in humans

Sujit S. Nair, Anitha Bommana, Suresh B. Pakala, Kazufumi Ohshiro, Amanda J. Lyon, Sutas Suttiprapa, Maria V. Periago, Thewarach Laha, Peter J. Hotez, Jeffrey M. Bethony, Banchob Sripa, Paul J.

SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism

Weiwei Tao, Siyu Chen, Guangsen Shi, Jinhu Guo, Ying Xu, Chang Liu – 2 July 2011 – Many aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism, are under precise control by the mammalian circadian clock. However, the molecular mechanism for coordinate integration of the circadian clock and various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin‐remodeling complex subunit, is rhythmically expressed in the liver of mice.

The assessment of serum hepatitis C virus RNA 12 weeks after the end of treatment using TaqMan polymerase chain reaction is less relevant than after 24 weeks for predicting sustained virological response

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

Kristina M. Mueller, Jan‐Wilhelm Kornfeld, Katrin Friedbichler, Leander Blaas, Gerda Egger, Harald Esterbauer, Peter Hasselblatt, Michaela Schlederer, Susanne Haindl, Kay‐Uwe Wagner, David Engblom, Guenter Haemmerle, Dagmar Kratky, Veronika Sexl, Lukas Kenner, Andrey V. Kozlov, Luigi Terracciano, Rudolf Zechner, Guenther Schuetz, Emilio Casanova, J. Andrew Pospisilik, Markus H.

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