Effect of intermittent hepatic inflow occlusion with the Pringle maneuver during donor hepatectomy in adult living donor liver transplantation with right hemiliver grafts: A prospective, randomized controlled study

Jae Berm Park, Jae‐Won Joh, Sung‐Joo Kim, Choon‐Hyuck David Kwon, Jae Min Chun, Jong Man Kim, Ju Ik Moon, Suk‐Koo Lee – 11 August 2011 – To evaluate the effects of intermittent hepatic inflow occlusion (IHIO) during donor hepatectomy for living donor liver transplantation (LDLT) in recipients and donors, we performed a single‐center, open‐label, prospective, parallel, randomized controlled study. Adult donor‐recipient pairs undergoing LDLT with right hemiliver grafts were randomized into IHIO and control groups (1:1). In the IHIO group, IHIO was performed during donor hepatectomy.

The Australia antigen and role of the late Philadelphia general hospital in reducing post‐transfusion hepatitis and sequelae

John R. Senior, W. Thomas London, Alton I. Sutnick – 1 August 2011 – Baruch Blumberg, who received the Nobel Prize for Physiology or Medicine for his discovery of the Australia antigen, died on April 5, 2011. Arguably, that discovery has been the most important advance in the field of Hepatology. It led to the virtual elimination of transfusion related hepatitis B in most parts of the world and was essential to the identification of hepatitis A, C, D and E viruses. Credit for this is due Dr. Blumberg and teams in Philadelphia and Tokyo. In lieu of an Associate Editor commentary, Drs.

Urinary ethyl glucuronide as a novel screening tool in patients pre‐ and post–liver transplantation improves detection of alcohol consumption

Katharina Staufer, Hilke Andresen, Eik Vettorazzi, Niels Tobias, Bjoern Nashan, Martina Sterneck – 1 August 2011 – Optimal selection of liver transplant candidates and early detection of alcohol relapse after orthotopic liver transplantation (OLT) is necessary to improve long‐term outcomes. In this study, urinary ethyl glucuronide (uEtG) was prospectively evaluated as a novel screening tool for alcohol detection in the transplant setting. Overall, 141 liver transplant candidates and recipients, visiting the outpatient clinic for a total of 308 times, were included.

A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart

Michele Miragoli, Siti H. Sheikh Abdul Kadir, Mary N. Sheppard, Nicoló Salvarani, Matilda Virta, Sarah Wells, Max J. Lab, Viacheslav O. Nikolaev, Alexey Moshkov, William M. Hague, Stephan Rohr, Catherine Williamson, Julia Gorelik – 1 August 2011 – Intrahepatic cholestasis of pregnancy may be complicated by fetal arrhythmia, fetal hypoxia, preterm labor, and, in severe cases, intrauterine death. The precise etiology of fetal death is not known. However, taurocholate has been demonstrated to cause arrhythmia and abnormal calcium dynamics in cardiomyocytes.

Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression

Yoo‐Mee Vanwijngaerden, Joost Wauters, Lies Langouche, Sarah Vander Perre, Christopher Liddle, Sally Coulter, Sara Vanderborght, Tania Roskams, Alexander Wilmer, Greet Van den Berghe, Dieter Mesotten – 28 July 2011 – Hyperbilirubinemia is common during critical illness and is associated with adverse outcome. Whether hyperbilirubinemia reflects intensive care unit (ICU) cholestasis is unclear. Therefore, the aim of this study was to analyze hyperbilirubinemia in conjunction with serum bile acids (BAs) and the key steps in BA synthesis, transport, and regulation by nuclear receptors (NRs).

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