Hepatic blood flow plays an important role in ischemia‐reperfusion injury

Dympna M. Kelly, Hiroaki Shiba, Shunichi Nakagawa, Samuel Irefin, Bijan Eghtesad, Cristiano Quintini, Federico Aucejo, Koji Hashimoto, John J. Fung, Charles Miller – 19 August 2011 – Severe ischemia/reperfusion (IR) injury is associated with poor hepatic microperfusion. The aim of this study was to investigate the role of hepatic artery flow (HAF) and portal vein flow (PVF) in IR injury. From January 2004 to June 2008, 566 patients underwent orthotopic liver transplantation (OLT). The data were retrospectively reviewed via the transplant database.

Burden of cirrhosis on older Americans and their families: Analysis of the health and retirement study

Mina O. Rakoski, Ryan J. McCammon, John D. Piette, Theodore J. Iwashyna, Jorge A. Marrero, Anna S. Lok, Kenneth M. Langa, Michael L. Volk – 19 August 2011 – Prevalence of cirrhosis among older adults is expected to increase; therefore, we studied the health status, functional disability, and need for supportive care in a large national sample of individuals with cirrhosis. A prospective cohort of individuals with cirrhosis was identified within the longitudinal, nationally representative Health and Retirement Study.

A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C

Göran B. Klintmalm, Gary L. Davis, Lewis Teperman, George J. Netto, Kenneth Washburn, Stephen M. Rudich, Elizabeth A. Pomfret, Hugo E. Vargas, Robert Brown, Devin Eckhoff, Timothy L. Pruett, John Roberts, David C. Mulligan, Michael R. Charlton, Thomas G. Heffron, John M. Ham, David D. Douglas, Linda Sher, Prabhakar K. Baliga, Milan Kinkhabwala, Baburao Koneru, Michael Abecassis, Michael Millis, Linda W. Jennings, Carlos G.

Patients with non–[18F]fludeoxyglucose‐avid advanced hepatocellular carcinoma on clinical staging may achieve long‐term recurrence‐free survival after liver transplantation

Arno Kornberg, Bernadett Küpper, Andrea Tannapfel, Peter Büchler, Babette Krause, Ulrike Witt, Dietmar Gottschild, Helmut Friess – 17 August 2011 – There is increasing evidence that a relevant number of patients with hepatocellular carcinoma (HCC) exceeding the Milan criteria may benefit from liver transplantation (LT). We retrospectively analyzed the prognostic significance of [18F]fludeoxyglucose ([18F]FDG) positron emission tomography (PET) for identifying appropriate LT candidates with advanced HCC on clinical staging. Between 1995 and 2008, 111 patients with HCC were listed for LT.

Computed tomography liver volumetry using 3‐dimensional image data in living donor liver transplantation: Effects of the slice thickness on the volume calculation

Masatoshi Hori, Kenji Suzuki, Mark L. Epstein, Richard L. Baron – 17 August 2011 – The purpose of this study was to evaluate the relationship between the slice thickness and the calculated volume in computed tomography (CT) liver volumetry through the comparison of the results from images [including 3‐dimensional (3D) images] with various slice thicknesses. Twenty potential adult liver donors (12 men and 8 women) with a mean age of 39 years (range = 24‐64 years) underwent CT with a 64‐section multidetector row CT scanner after the intravenous injection of a contrast material.

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