Shi Liu, Qian Hao, Nanfang Peng, Xin Yue, Yu Wang, Yanni Chen, Jianguo Wu, Ying Zhu – 9 February 2012 – Major vault protein (MVP) is the major constituent of vaults and is involved in multidrug resistance, nucleocytoplasmic transport, and cell signaling. However, little is known about the role of MVP during viral infections. In this study, high levels of MVP were found in peripheral blood mononuclear cells, sera, and liver tissue from patients infected with hepatitis C virus (HCV) relative to healthy individuals.

Bo Wang, Shu‐Hao Hsu, Wendy Frankel, Kalpana Ghoshal, Samson T. Jacob – 9 February 2012 – Considerable effort has been made in elucidating the mechanism and functional significance of high levels of aerobic glycolysis in cancer cells, commonly referred to as the Warburg effect. Here we investigated whether the gluconeogenic pathway is significantly modulated in hepatocarcinogenesis, resulting in altered levels of glucose homeostasis.

Kei Moriya, Keiko Sakai, Michel H. Yan, Takao Sakai – 9 February 2012 – Acute liver injury causes massive hepatocyte apoptosis and/or fatal liver damage. Fibronectin, an extracellular matrix glycoprotein, is prominently expressed during adult tissue repair. However, the extent of fibronectin dependence on hepatocyte response to acute liver damage remains to be defined.

Wen‐Lung Ma, Cheng‐Lung Hsu, Chun‐Chieh Yeh, Ming‐Heng Wu, Chiung‐Kuei Huang, Long‐Bin Jeng, Yao‐Ching Hung, Tze‐Yi Lin, Shuyuan Yeh, Chawnshang Chang – 9 February 2012 – Early reports suggested androgen/androgen receptor (AR) signals promote hepatocarcinogenesis. However, all antiandrogen clinical trials failed in advanced hepatocellular carcinoma (HCC) without reasonable explanations. We examined AR functions in HCC cancer metastasis in this study.

Andrew D. Patterson, Yatrik M. Shah, Tsutomu Matsubara, Kristopher W. Krausz, Frank J. Gonzalez – 9 February 2012 – Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis.

Alia S. Dadabhai, Jonathan M. Fenkel, Daniel B. Brown, Loren Laine – 9 February 2012

Eugenio Caturelli, Giorgia Ghittoni – 9 February 2012

Alia S. Dadabhai, Jonathan M. Fenkel, Daniel B. Brown, Loren Laine – 9 February 2012

Maddalena Frau, Maria L. Tomasi, Maria M. Simile, Maria I. Demartis, Fabiana Salis, Gavinella Latte, Diego F. Calvisi, Maria A. Seddaiu, Lucia Daino, Claudio F. Feo, Stefania Brozzetti, Giuliana Solinas, Satoshi Yamashita, Toshikazu Ushijima, Francesco Feo, Rosa M. Pascale – 9 February 2012 – Down‐regulation of the liver‐specific MAT1A gene, encoding S‐adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up‐regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC).

Robert Hayden Broomhead, Sanjiv Patel, Bimbi Fernando, James O'Beirne, Susan Mallett – 8 February 2012 – In the United Kingdom, liver transplantation using donation after circulatory determination of death (DCDD) organs has increased steadily over the last few years and now accounts for 20% of UK transplant activity. The procurement of DCDD livers is actively promoted as a means of increasing the donor pool and bridging the evolving disparity between the wait‐list length and the number of transplants performed.