Renal function in patients undergoing transplantation for nonalcoholic steatohepatitis cirrhosis: Time to reconsider immunosuppression regimens?

Diarmaid D. Houlihan, Matthew J. Armstrong, Yana Davidov, James Hodson, Peter Nightingale, Ian A. Rowe, Sue Paris, Bridget K. Gunson, Simon B. Bramhall, David J. Mutimer, James M. Neuberger, Philip N. Newsome – 14 July 2011 – Nonalcoholic fatty liver disease is an independent risk factor for chronic kidney injury (CKI), yet the impact of liver transplantation (LT) on renal function in this at‐risk group is not known. We compared the post‐LT renal function of patients with nonalcoholic steatohepatitis (NASH) and a matched comparison group.

Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus

Mustafa Ates, Abuzer Dirican, Dincer Ozgor, Cemalettin Aydin, Burak Isik, Cengiz Ara, Mehmet Yilmaz, M. Ayse Selimoglu, Cuneyt Kayaalp, Sezai Yilmaz – 14 July 2011 – Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus, either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to acute liver failure (ALF). We present the outcomes of 10 children who ingested fireworks containing yellow phosphorus.

Anemia is not predictive of sustained virological response in liver transplant recipients with hepatitis C virus who are treated with pegylated interferon and ribavirin

Michela Giusto, Maria Rodriguez, Laia Navarro, Angel Rubin, Victoria Aguilera, Fernando San‐Juan, Cecilia Ortiz, Rafael López‐Andujar, Martín Prieto, Marina Berenguer – 14 July 2011 – In the immunocompetent setting, antiviral therapy–related anemia has recently been shown to be associated with a sustained virological response (SVR). Our goal was to assess whether this is also true for liver transplantation (LT).

Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes

Emma A. Kruglov, Samir Gautam, Mateus T. Guerra, Michael H. Nathanson – 11 July 2011 – Bile salt secretion is mediated primarily by the bile salt export pump (Bsep), a transporter on the canalicular membrane of the hepatocyte. However, little is known about the short‐term regulation of Bsep activity. Ca2+ regulates targeting and insertion of transporters in many cell systems, and Ca2+ release near the canalicular membrane is mediated by the type II inositol 1,4,5‐trisphosphate receptor (InsP3R2), so we investigated the possible role of InsP3R2 in modulating Bsep activity.

Nuclear factor high‐mobility group box1 mediating the activation of toll‐like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

Liang Li, Lei Chen, Liang Hu, Yuan Liu, Han‐Yong Sun, Jing Tang, Yu‐Jie Hou, Yan‐Xin Chang, Qian‐Qian Tu, Gen‐Sheng Feng, Feng Shen, Meng‐Chao Wu, Hong‐Yang Wang – 11 July 2011 – One of the challenges surrounding nonalcoholic fatty liver disease (NAFLD) is to discover the mechanisms that underlie the initiation of it. The aim of the present study was to elucidate the effects of Toll‐like receptor 4 (TLR4) signaling in liver parenchymal cells during the early stage of NAFLD.

Dual farnesoid X receptor/TGR5 agonist INT‐767 reduces liver injury in the Mdr2−/− (Abcb4−/−) mouse cholangiopathy model by promoting biliary HCO output

Anna Baghdasaryan, Thierry Claudel, Judith Gumhold, Dagmar Silbert, Luciano Adorini, Aldo Roda, Stefania Vecchiotti, Frank J. Gonzalez, Kristina Schoonjans, Mario Strazzabosco, Peter Fickert, Michael Trauner – 11 July 2011 – Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. The nuclear farnesoid X receptor (FXR) and the membrane G protein‐coupled receptor, TGR5, regulate bile acid (BA) homeostasis and inflammation.

Subscribe to