The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

Jingling Jin, Polina Iakova, Yanjun Jiang, Estela E. Medrano, Nikolai A. Timchenko – 2 June 2011 – Age declines liver functions, leading to the development of age‐associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of glucose homeostasis and fat metabolism. Because aging livers have alterations in glucose and fat metabolism, we examined a possible role of SIRT1 in these alterations. We found that aged livers have a reduced expression of SIRT1 and have lost proper control of the regulation of SIRT1 after partial hepatectomy (PH).

Liver allocation and distribution: Possible next steps

Kenneth Washburn, Elizabeth Pomfret, John Roberts – 1 June 2011 – Recent discussions about the distribution of cadaveric liver allografts for transplantation have raised many important issues. Over the past 2 years, a deliberative process including discussions, modeling, a request for information, a public forum, and a concept document has led to a greater focus on a possible path for reducing wait‐list mortality. Here we describe that process, our interpretation of the feedback and responses, and possible recommendations. Liver Transpl 17:1005–1012, 2011. © 2011 AASLD.

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