Liver transplantation for acute intermittent porphyria is complicated by a high rate of hepatic artery thrombosis

Joanna K. Dowman, Bridget K. Gunson, Darius F. Mirza, Simon R. Bramhall, Mike N. Badminton, Philip N. Newsome, on behalf of the UK Liver Selection and Allocation Working Party – 26 May 2011 – Acute intermittent porphyria (AIP) is an autosomal‐dominant condition resulting from a partial deficiency of the ubiquitously expressed enzyme porphobilinogen deaminase. Although its clinical expression is highly variable, a minority of patients suffer recurrent life‐threatening neurovisceral attacks despite optimal medical therapy.

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta‐analysis

Ruben Hernaez, Mariana Lazo, Susanne Bonekamp, Ihab Kamel, Frederick L. Brancati, Eliseo Guallar, Jeanne M. Clark – 26 May 2011 – Ultrasonography is a widely accessible imaging technique for the detection of fatty liver, but the reported accuracy and reliability have been inconsistent across studies. We aimed to perform a systematic review and meta‐analysis of the diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver. We used MEDLINE and Embase from October 1967 to March 2010.

Transcriptome at the time of hepatitis C virus recurrence may predict the severity of fibrosis progression after liver transplantation

Valeria Mas, Daniel Maluf, Kellie J. Archer, Amiee Potter, Jihee Suh, Ricardo Gehrau, Valeria Descalzi, Federico Villamil – 26 May 2011 – Allograft gene expression analysis may provide insights into the mechanisms involved in liver damage during hepatitis C virus recurrence (HCVrec) after orthotopic liver transplantation (OLT) and allow the identification of patients who have a higher risk of developing severe disease. Forty‐three OLT recipients with hepatitis C virus (HCV) were evaluated.

Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma

Amr Amin, Alaaeldin A. Hamza, Khuloud Bajbouj, S. Salman Ashraf, Sayel Daoud – 23 May 2011 – Saffron has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of saffron against diethylnitrosamine (DEN)‐induced liver cancer in rats. Administration of saffron at doses of 75, 150, and 300 mg/kg/day was started 2 weeks prior to the DEN injection and was continued for 22 weeks.

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