Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch‐up immunization program
Brian J. McMahon, Lisa R. Bulkow, Rosalyn J. Singleton, James Williams, Mary Snowball, Chriss Homan, Alan J. Parkinson – 26 May 2011 – Alaska Native people experience the highest rates of acute and chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) in the United States. We examined the effect of a universal newborn immunization with hepatitis B vaccine and mass population screening immunization program initiated in 1984 on rates of HBV and HCC in children 25 years later.
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways
Jens U. Marquardt, Chiara Raggi, Jesper B. Andersen, Daekwan Seo, Itzhak Avital, David Geller, Yun‐Han Lee, Mitsuteru Kitade, Agnes Holczbauer, Matthew C. Gillen, Elizabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson – 26 May 2011 – Epigenetic mechanisms play critical roles in stem cell biology by maintaining pluripotency of stem cells and promoting differentiation of more mature derivatives.
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Xiuchan Guo, Randy Johnson, Stephen J. O'Brien – 26 May 2011
Liver and serum iron: Discrete regulators of hepatic hepcidin expression
Anita C. G. Chua, Debbie Trinder, John K. Olynyk – 26 May 2011
Survival after yttrium‐90 resin microsphere radioembolization of hepatocellular carcinoma across Barcelona clinic liver cancer stages: A European evaluation
Bruno Sangro, Livio Carpanese, Roberto Cianni, Rita Golfieri, Daniele Gasparini, Samer Ezziddin, Philipp M.
Molecular imaging of hepatic stellate cell activity by visualization of hepatic integrin αvβ3 expression with SPECT in rat
Feng Li, Zhengji Song, Qinghua Li, Jian Wu, Jiyao Wang, Cao Xie, Chuantao Tu, Jian Wang, Xiaowei Huang, Weiyue Lu – 26 May 2011 – The key factors in the pathogenesis of liver fibrosis are the activation and proliferation of hepatic stellate cells (HSCs), which express integrin αvβ3 after activation. This study aimed to explore the potential of 99mTc‐labeled cyclic arginine‐glycine‐aspartic acid pentapeptide (cRGD) as a single photon emission computed tomography (SPECT) radiotracer to image hepatic integrin αvβ3 expression to reflect HSC activity in fibrotic livers.
Mortality in nonalcoholic fatty liver disease: Clues from the cremona study
Leon A. Adams – 26 May 2011
Safety of liver transplantation with chagas disease–seropositive donors for seronegative recipients
Fernando Salvador, Oscar Len, Israel Molina, Elena Sulleiro, Silvia Sauleda, Itxarone Bilbao, Lluis Castells, Teresa Pont, Joan Gavaldà, Albert Pahissa – 26 May 2011 – The shortage of organs for transplantation has prompted the investigation of extended criteria donors, such as donors with transmissible infectious diseases. Here we report our recent experience with liver transplantation using organs from donors who were serologically positive for Chagas disease. We also provide a review of the literature and emphasize donor screening and preventive measures.