Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo

Nobuhiko Hiraga, Michio Imamura, Hiromi Abe, C. Nelson Hayes, Tomohiko Kono, Mayu Onishi, Masataka Tsuge, Shoichi Takahashi, Hidenori Ochi, Eiji Iwao, Naohiro Kamiya, Ichimaro Yamada, Chise Tateno, Katsutoshi Yoshizato, Hirotaka Matsui, Akinori Kanai, Toshiya Inaba, Shinji Tanaka, Kazuaki Chayama – 29 May 2011 – Telaprevir is a potent inhibitor of hepatitis C virus (HCV) NS3‐4A protease.

CXC chemokine signaling in the liver: Impact on repair and regeneration

Heather L. Van Sweringen, Nozomu Sakai, Amit D. Tevar, Justin M. Burns, Michael J. Edwards, Alex B. Lentsch – 29 May 2011 – The process of liver repair and regeneration following hepatic injury is complex and relies on a temporally coordinated integration of several key signaling pathways. Pathways activated by members of the CXC family of chemokines play important roles in the mechanisms of liver repair and regeneration through their effects on hepatocytes. However, little is known about the signaling pathways used by CXC chemokine receptors in hepatocytes.

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival‐promoting autophagy

Nadezda Apostolova, Leysa J. Gomez‐Sucerquia, Anna Gortat, Ana Blas‐Garcia, Juan V. Esplugues – 29 May 2011 – Hepatotoxicity is a very common side effect associated with the pharmacological treatment of human immunodeficiency virus (HIV) infection and its pathogenesis is poorly understood. Efavirenz (EFV) is the most widely used nonnucleoside reverse transcriptase inhibitor administered for the control of HIV and some of its toxic effects in hepatic cells have been recently shown to display features of mitochondrial dysfunction.

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