Predictors of early graft survival after pediatric liver transplantation

Ruben Ciria, Diego Davila, Shirin E. Khorsandi, Faisal Dar, Roberto Valente, Javier Briceño, Hector Vilca‐Melendez, Anil Dhawan, Mohamed Rela, Nigel D. Heaton – 10 August 2012 – The objective of this study was to identify peritransplant predictors of early graft survival and posttransplant parameters that could be used to predict early graft outcomes after pediatric liver transplantation (PLT). The response of children to liver dysfunction after liver transplantation (LT) is poor.

Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

Gitte Dam, Susanne Keiding, Ole L. Munk, Peter Ott, Hendrik Vilstrup, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe, Michael Sørensen – 10 August 2012 – Studies have shown decreased cerebral oxygen metabolism (CMRO2) and blood flow (CBF) in patients with cirrhosis with hepatic encephalopathy (HE). It remains unclear, however, whether these disturbances are associated with HE or with cirrhosis itself and how they may relate to arterial blood ammonia concentration and cerebral metabolic rate of blood ammonia (CMRA).

Yes‐associated protein regulates the hepatic response after bile duct ligation

Haibo Bai, Nailing Zhang, Yang Xu, Qian Chen, Mehtab Khan, James J. Potter, Suresh K. Nayar, Toby Cornish, Gianfranco Alpini, Steven Bronk, Duojia Pan, Robert A. Anders – 8 August 2012 – Human chronic cholestatic liver diseases are characterized by cholangiocyte proliferation, hepatocyte injury, and fibrosis. Yes‐associated protein (YAP), the effector of the Hippo tumor‐suppressor pathway, has been shown to play a critical role in promoting cholangiocyte and hepatocyte proliferation and survival during embryonic liver development and hepatocellular carcinogenesis.

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