Matthias Evert, Diego F. Calvisi, Katja Evert, Valentina De Murtas, Gioia Gasparetti, Sandra Mattu, Giulia Destefanis, Sara Ladu, Antje Zimmermann, Salvatore Delogu, Sara Thiel, Andrea Thiele, Silvia Ribback, Frank Dombrowski – 23 January 2012 – Mounting epidemiological evidence supports a role for insulin‐signaling deregulation and diabetes mellitus in human hepatocarcinogenesis. However, the underlying molecular mechanisms remain unknown.

Ming Liu, Leilei Chen, Tim Hon Man Chan, Jian Wang, Yan Li, Yan Li, Ting‐Ting Zeng, Yun‐Fei Yuan, Xin‐Yuan Guan – 19 January 2012 – Amplification of broad regions of 8q is one of the most frequent genetic alterations in hepatocellular carcinoma (HCC), suggesting the existence of oncogenes in addition to MYC at 8q24.21. In this report we examine the potential role of the candidate amplified oncogene serum and glucocorticoid kinase 3 (SGK3) at 8q13.1 in HCC pathogenesis.

Ian A. Rowe, Matthew J. Armstrong, Richard Parker, Diarmaid D. Houlihan – 19 January 2012

Darren G. Craig, Kenneth J. Simpson – 19 January 2012

Vincenzo Cardinale, Yunfang Wang, Guido Carpino, Lola M. Reid, Eugenio Gaudio, Domenico Alvaro – 19 January 2012

Gregory Gores, Keith D. Lindor, Nataliya Razumilava – 19 January 2012

Hossein Poutschi, Jacob George – 19 January 2012

Christoph Schramm, Ansgar W. Lohse – 19 January 2012

Yasuni Nakanuma, Yasunori Sato – 19 January 2012

Hisamitsu Hayashi, Kaori Inamura, Kensuke Aida, Sotaro Naoi, Reiko Horikawa, Hironori Nagasaka, Tomozumi Takatani, Tamio Fukushima, Asami Hattori, Takashi Yabuki, Ikuo Horii, Yuichi Sugiyama – 19 January 2012 – The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis. Reduced canalicular expression of BSEP resulting from the promotion of its internalization is one of the causes of this disease state. However, the molecular mechanism underlying BSEP internalization from the canalicular membrane (CM) remains unknown.