Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch‐up immunization program

Brian J. McMahon, Lisa R. Bulkow, Rosalyn J. Singleton, James Williams, Mary Snowball, Chriss Homan, Alan J. Parkinson – 26 May 2011 – Alaska Native people experience the highest rates of acute and chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) in the United States. We examined the effect of a universal newborn immunization with hepatitis B vaccine and mass population screening immunization program initiated in 1984 on rates of HBV and HCC in children 25 years later.

Nuclear expression of S100A4 calcium‐binding protein increases cholangiocarcinoma invasiveness and metastasization

Luca Fabris, Massimiliano Cadamuro, Lidia Moserle, James Dziura, Xiangyu Cong, Luisa Sambado, Giorgia Nardo, Aurelio Sonzogni, Michele Colledan, Alberto Furlanetto, Nicolò Bassi, Marco Massani, Umberto Cillo, Claudia Mescoli, Stefano Indraccolo, Massimo Rugge, Lajos Okolicsanyi, Mario Strazzabosco – 26 May 2011 – Cholangiocarcinoma (CCA) carries a severe prognosis because of its strong invasiveness and early metastasization. In several patients, otherwise eligible for surgical resection, micrometastasis are already present at the time of surgery.

Liver transplantation for acute intermittent porphyria is complicated by a high rate of hepatic artery thrombosis

Joanna K. Dowman, Bridget K. Gunson, Darius F. Mirza, Simon R. Bramhall, Mike N. Badminton, Philip N. Newsome, on behalf of the UK Liver Selection and Allocation Working Party – 26 May 2011 – Acute intermittent porphyria (AIP) is an autosomal‐dominant condition resulting from a partial deficiency of the ubiquitously expressed enzyme porphobilinogen deaminase. Although its clinical expression is highly variable, a minority of patients suffer recurrent life‐threatening neurovisceral attacks despite optimal medical therapy.

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta‐analysis

Ruben Hernaez, Mariana Lazo, Susanne Bonekamp, Ihab Kamel, Frederick L. Brancati, Eliseo Guallar, Jeanne M. Clark – 26 May 2011 – Ultrasonography is a widely accessible imaging technique for the detection of fatty liver, but the reported accuracy and reliability have been inconsistent across studies. We aimed to perform a systematic review and meta‐analysis of the diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver. We used MEDLINE and Embase from October 1967 to March 2010.

Transcriptome at the time of hepatitis C virus recurrence may predict the severity of fibrosis progression after liver transplantation

Valeria Mas, Daniel Maluf, Kellie J. Archer, Amiee Potter, Jihee Suh, Ricardo Gehrau, Valeria Descalzi, Federico Villamil – 26 May 2011 – Allograft gene expression analysis may provide insights into the mechanisms involved in liver damage during hepatitis C virus recurrence (HCVrec) after orthotopic liver transplantation (OLT) and allow the identification of patients who have a higher risk of developing severe disease. Forty‐three OLT recipients with hepatitis C virus (HCV) were evaluated.

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