Seven cases of autoimmune hepatitis that developed after drug‐induced liver injury
Kazushi Sugimoto, Takeshi Ito, Norihiko Yamamoto, Katsuya Shiraki – 2 July 2011
PUMA–mediated apoptosis drives chemical hepatocarcinogenesis in mice
Wei Qiu, Xinwei Wang, Brian Leibowitz, Wancai Yang, Lin Zhang, Jian Yu – 2 July 2011 – Hepatocyte death and proliferation contribute to hepatocellular carcinoma development after carcinogen exposure or chronic liver inflammation. However, the role and the molecular targets of hepatocyte death in relation to compensatory proliferation have not been fully characterized.
Correction
2 July 2011
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice
Kristina M. Mueller, Jan‐Wilhelm Kornfeld, Katrin Friedbichler, Leander Blaas, Gerda Egger, Harald Esterbauer, Peter Hasselblatt, Michaela Schlederer, Susanne Haindl, Kay‐Uwe Wagner, David Engblom, Guenter Haemmerle, Dagmar Kratky, Veronika Sexl, Lukas Kenner, Andrey V. Kozlov, Luigi Terracciano, Rudolf Zechner, Guenther Schuetz, Emilio Casanova, J. Andrew Pospisilik, Markus H.
The assessment of serum hepatitis C virus RNA 12 weeks after the end of treatment using TaqMan polymerase chain reaction is less relevant than after 24 weeks for predicting sustained virological response
Tatsuo Kanda, Fumio Imazeki, Shuang Wu, Shingo Nakamoto, Osamu Yokosuka – 2 July 2011
SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism
Weiwei Tao, Siyu Chen, Guangsen Shi, Jinhu Guo, Ying Xu, Chang Liu – 2 July 2011 – Many aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism, are under precise control by the mammalian circadian clock. However, the molecular mechanism for coordinate integration of the circadian clock and various metabolic pathways is poorly understood. Here we show that BAF60a, a chromatin‐remodeling complex subunit, is rhythmically expressed in the liver of mice.
Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite‐induced cholangiocarcinoma in humans
Sujit S. Nair, Anitha Bommana, Suresh B. Pakala, Kazufumi Ohshiro, Amanda J. Lyon, Sutas Suttiprapa, Maria V. Periago, Thewarach Laha, Peter J. Hotez, Jeffrey M. Bethony, Banchob Sripa, Paul J.
Biomarkers of liver fibrosis: What lies beneath the receiver operating characteristic curve?
Indra Neil Guha, Robert P. Myers, Keyur Patel, Jayant A. Talwalkar – 2 July 2011 – Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies.
Fighting against viral hepatitis: Lessons from Taiwan
Ding‐Shinn Chen – 30 June 2011 – Viral hepatitis and its sequelae are important health problems worldwide, including Taiwan. For the last 40 years, Taiwan's scientists and health care providers have worked hard to control these sequelae, and the results have been excellent. The author, Ding‐Shinn Chen, had a key role in planning and establishing the control program in Taiwan, and participated in the endeavors from the very beginning.
Cross‐presentation of antigen by diverse subsets of murine liver cells
Mohammad R. Ebrahimkhani, Isaac Mohar, Ian N. Crispe – 30 June 2011 – Antigen cross‐presentation is a principal function of specialized antigen‐presenting cells of bone marrow origin such as dendritic cells. Although these cells are sometimes known as “professional” antigen‐presenting cells, nonbone marrow‐derived cells may also act as antigen‐presenting cells.