Jun‐Xiang Zhang, Da‐Qiang Li, Aiwu Ruth He, Mona Motwani, Vasilis Vasiliou, Jeyanthy Eswaran, Lopa Mishra, Rakesh Kumar – 27 December 2011 – Hepatocellular carcinoma (HCC) is a particularly lethal form of cancer, yet effective therapeutic options for advanced HCC are limited. The poly(ADP‐ribose) polymerases (PARPs) and histone deacetylases (HDACs) are emerging to be among the most promising targets in cancer therapy, and sensitivity to PARP inhibition depends on homologous recombination (HR) deficiency and inhibition of HDAC activity blocks the HR pathway.

Brian L. Pearlman, Carole Ehleben – 27 December 2011

Ruiqun Qi, Matthew Weiland, Xing‐Hua Gao, Li Zhou, Qing‐Sheng Mi – 27 December 2011

Liangliang Xu, Wenguang Yin, Jianhong Xia, Meixiu Peng, Song Li, Shuo Lin, Duanqing Pei, Xiaodong Shu – 27 December 2011

Germán Soriano, Eva Román, Joan Córdoba, Maria Torrens, Maria Poca, Xavier Torras, Càndid Villanueva, Ignasi J. Gich, Víctor Vargas, Carlos Guarner – 27 December 2011 – Falls are frequent among patients with debilitating disorders and can have a serious effect on health status. Mild cognitive disturbances associated with cirrhosis may increase the risk for falls. Identifying subjects at risk may allow the implementation of preventive measures. Our aim was to assess the predictive value of the Psychometric Hepatic Encephalopathy Score (PHES) in identifying patients likely to sustain falls.

Maxine M. Denniston, R. Monina Klevens, Geraldine M. McQuillan, Ruth B. Jiles – 27 December 2011 – Many persons infected with hepatitis C virus (HCV) are unknown to the healthcare system because they may be asymptomatic for years, have not been tested for HCV infection, and only seek medical care when they develop liver‐related complications. We analyzed data from persons who tested positive for past or current HCV infection during participation in the National Health and Nutrition Examination Survey (NHANES) from 2001 through 2008.

Marcin Krawczyk, Dieter Lütjohann, Ramin Schirin‐Sokhan, Luis Villarroel, Flavio Nervi, Fernando Pimentel, Frank Lammert, Juan Francisco Miquel – 27 December 2011 – In hepatocytes and enterocytes sterol uptake and secretion is mediated by Niemann‐Pick C1‐like 1 (NPC1L1) and ATP‐binding cassette (ABC)G5/8 proteins, respectively. Whereas serum levels of phytosterols represent surrogate markers for intestinal cholesterol absorption, cholesterol precursors reflect cholesterol biosynthesis.

Philip Starkey Lewis, James Dear, Vivien Platt, Jonathan Moggs, Chris Goldring, B. Kevin Park – 27 December 2011

Ian A. Rowe, Matthew J. Armstrong, Diarmaid D. Houlihan – 27 December 2011

Guoyuan Liu, Songmin Jiang, Chenji Wang, Wei Jiang, Zulong Liu, Chao Liu, Hexige Saiyin, Xianmei Yang, Suqin Shen, Deke Jiang, Ping Zhou, Dingding Han, Xiaohui Hu, Qing Yi, Long Yu – 27 December 2011 – Activation of β‐catenin, the central effector of the canonical wingless‐type (Wnt) pathway, has been implicated in hepatocellular carcinoma (HCC). However, the transcription regulation mechanism of the β‐catenin gene in HCC remains unknown. Here we report that human zinc finger protein 191 (ZNF191) is a potential regulator of β‐catenin transcription.