Jingmin Shu, Betsy T. Kren, Zhilian Xia, Phillip Y.‐P. Wong, Lihua Li, Eric A. Hanse, Michael X. Min, Bingshan Li, Jeffrey H. Albrecht, Yan Zeng, Subbaya Subramanian, Clifford J. Steer – 13 May 2011 – The liver is one of the few organs that have the capacity to regenerate in response to injury. We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their role. At 3, 12, and 18 hours post‐PH ∼40% of the miRNAs tested were up‐regulated.

Haruhiko Yoshida, Yasushi Shiratori, Masatoshi Kudo, Shuichiro Shiina, Toshihiko Mizuta, Masamichi Kojiro, Kyosuke Yamamoto, Yukihiro Koike, Kenichi Saito, Nozomu Koyanagi, Takao Kawabe, Seiji Kawazoe, Haruhiko Kobashi, Hiroshi Kasugai, Yukio Osaki, Yasuyuki Araki, Namiki Izumi, Hiroko Oka, Kunihiko Tsuji, Joji Toyota, Toshihito Seki, Toshiya Osawa, Naohiko Masaki, Masao Ichinose, Masataka Seike, Akihisa Ishikawa, Yoshiyuki Ueno, Kazumi Tagawa, Ryoko Kuromatsu, Shotaro Sakisaka, Hiroshi Ikeda, Hidekatsu Kuroda, Hiroyuki Kokuryu, Tatsuya Yamashita, Isao Sakaida, Tetsuo Katamoto, Kentaro Kiku

Chih‐Wen Lin, Wendy M. Mars, Shirish Paranjpe, Shashikiran Donthamsetty, Vishakha S. Bhave, Liang‐I Kang, Anne Orr, William C. Bowen, Aaron W. Bell, George K. Michalopoulos – 13 May 2011 – Glypican 3 (GPC3) is a family of glycosylphosphatidylinositol‐anchored, cell‐surface heparan sulfate proteoglycans. Loss‐of‐function mutations of GPC3 cause Simpson‐Golabi‐Behmel syndrome characterized by overgrowth of multiple organs, including liver.

Michael K. Connolly, Diego Ayo, Ashim Malhotra, Michael Hackman, Andrea S. Bedrosian, Junaid Ibrahim, Napoleon E. Cieza‐Rubio, Andrew H. Nguyen, Justin R. Henning, Monica Dorvil‐Castro, H. Leon Pachter, George Miller – 13 May 2011 – Acetaminophen (APAP) overdose is one of the most frequent causes of acute liver failure in the United States and is primarily mediated by toxic metabolites that accumulate in the liver upon depletion of glutathione stores.

Georgios N. Kalambokis, Athanasia Mouzaki, Maria Rodi, Konstantinos Pappas, Epameinondas V. Tsianos – 12 May 2011

Alexander R. Moschen, Romana Gerner, Andrea Schroll, Teresa Fritz, Arthur Kaser, Herbert Tilg – 12 May 2011 – Pre–B cell colony–enhancing factor (PBEF), also known as nicotinamide phosphoribosyltransferase or visfatin, plays an important role in metabolic, inflammatory, and malignant diseases. Recent evidence suggests that blocking its enzymatic activity using a specific small‐molecule inhibitor (FK866) might be beneficial in acute experimental inflammation. We investigated the role of PBEF in human liver disease and experimental hepatitis.

Dominique Thabut, Chittaranjan Routray, Gwen Lomberk, Uday Shergill, Kevin Glaser, Robert Huebert, Leena Patel, Tetyana Masyuk, Boris Blechacz, Andrew Vercnocke, Erik Ritman, Richard Ehman, Raul Urrutia, Vijay Shah – 12 May 2011 – Paracrine signaling between hepatic stellate cells (HSCs) and liver endothelial cells (LECs) modulates fibrogenesis, angiogenesis, and portal hypertension. However, mechanisms regulating these processes are not fully defined.

Feng Ren, Zhongping Duan, Qiao Cheng, Xiuda Shen, Feng Gao, Li Bai, Jun Liu, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Yuan Zhai – 12 May 2011 – The ubiquitous serine/threonine kinase glycogen synthase kinase 3 beta (Gsk3β) differentially regulates macrophage Toll‐like receptor (TLR)‐triggered pro‐ and anti‐inflammatory cytokine programs. This study was designed to determine the in vivo role and therapeutic potential of Gsk3β modulation in tissue inflammation and injury in a murine model of liver partial warm ischemia/reperfusion injury (IRI).

Tatsuki Mizuochi, Akihiko Kimura, Mitsuyoshi Suzuki, Isao Ueki, Hajime Takei, Hiroshi Nittono, Toshihiko Kakiuchi, Takanobu Shigeta, Seisuke Sakamoto, Akinari Fukuda, Atsuko Nakazawa, Toshiaki Shimizu, Takao Kurosawa, Mureo Kasahara – 12 May 2011 – Only 2 patients with an oxysterol 7α‐hydroxylase deficiency caused by mutations of the cytochrome P450 7B1 (CYP7B1) gene have been reported; for both, the outcome was fatal. We describe the clinical and laboratory features, the hepatic and renal histological findings, and the results of bile acid and CYP7B1 gene analyses for a third patient.

Kai Breuhahn, Gregory Gores, Peter Schirmacher – 12 May 2011