Sophie Clément, Marion Peyrou, Andrea Sanchez‐Pareja, Lucie Bourgoin, Pierluigi Ramadori, David Suter, Manlio Vinciguerra, Kevin Guilloux, Stephanie Pascarella, Laura Rubbia‐Brandt, Francesco Negro, Michelangelo Foti – 4 April 2011 – Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down‐regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mechanism leading to steatosis and its progression toward fibrosis and hepatocellular carcinoma.

Pablo Bellot, Jose Such, Jaime Bosch – 4 April 2011

Carla S. Coffin, Patricia M. Mulrooney‐Cousins, Guido van Marle, John P. Roberts, Tomasz I. Michalak, Norah A. Terrault – 1 April 2011 – The characterization of hepatitis B virus (HBV) quasispecies in different compartments in liver transplant (LT) recipients may be helpful in optimizing prophylaxis regimens. The aims of this study were to evaluate liver, peripheral blood mononuclear cells (PBMC), and plasma samples for HBV and to compare the quasispecies in hepatic and extrahepatic sites in LT recipients on long‐term prophylaxis.

Parsia A. Vagefi, Helge Eilers, Annie Hiniker, Chris E. Freise – 1 April 2011

Solange Bresson‐Hadni, Oleg Blagosklonov, Jenny Knapp, Frédéric Grenouillet, Yasuhito Sako, Eric Delabrousse, Marie‐Pascale Brientini, Carine Richou, Anne Minello, Anca‐Teodora Antonino, Michel Gillet, Akira Ito, Georges André Mantion, Dominique Angèle Vuitton – 31 March 2011 – Liver transplantation (LT) is currently contraindicated in patients with residual or metastatic alveolar echinococcosis (AE) lesions. We evaluated the long‐term course of such patients who underwent LT and were subsequently treated with benzimidazoles.

Sunil Dacha, Ashis Barad, John Martin, Josh Levitsky – 31 March 2011 – Biliary complications are important causes of morbidity and graft failure in patients after orthotopic liver transplantation. Nonanastomotic biliary strictures (NAS) are frequently the most challenging biliary complications. Hepatic artery stenosis (HAS) as a cause of biliary strictures has not been studied well systematically.

Bruno Roche, Didier Samuel – 31 March 2011

Irina Zemtsova, Boris Görg, Verena Keitel, Hans‐Jürgen Bidmon, Karsten Schrör, Dieter Häussinger – 30 March 2011 – Astrocytes play an important role in the pathogenesis of hepatic encephalopathy (HE) and ammonia toxicity, whereas little is known about microglia and neuroinflammation under these conditions. We therefore studied the effects of ammonia on rat microglia in vitro and in vivo and analyzed markers of neuroinflammation in post mortem brain tissue from patients with cirrhosis with and without HE and non‐cirrhotic controls.

Itziar Echeverria, Alexander Pereboev, Leyre Silva, Aintzane Zabaleta, José Ignacio Riezu‐Boj, Marta Bes, María Cubero, Francisco Borras‐Cuesta, Juan José Lasarte, Juan Ignacio Esteban, Jesús Prieto, Pablo Sarobe – 30 March 2011 – Injection of dendritic cells (DCs) presenting viral proteins constitutes a promising approach to stimulate T cell immunity against hepatitis C virus (HCV). Here we describe a strategy to enhance antigen loading and immunostimulatory functions of DCs useful in the preparation of therapeutic vaccines.

Bruce R. Bacon, Paul C. Adams, Kris V. Kowdley, Lawrie W. Powell, Anthony S. Tavill – 30 March 2011