Mouse patatin‐like phospholipase domain‐containing 3 influences systemic lipid and glucose homeostasis

Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang – 5 May 2011 – Human patatin‐like phospholipase domain‐containing 3 (PNPLA3) is associated with increased liver fat content and liver injury. Here, we show that nutritional status regulates PNPLA3 gene expression in the mouse liver. Sterol response element binding protein‐1 (SREBP‐1) activated PNPLA3 gene transcription via sterol regulatory elements (SREs) mapped to the promoter region.

Beneficial effects of supplementation with branched‐chain amino acids on postoperative bacteremia in living donor liver transplant recipients

Ken Shirabe, Masanori Yoshimatsu, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Jun Muto, Rumi Matono, Akinobu Taketomi, Hideaki Uchiyama, Yoshihiko Maehara – 3 May 2011 – The aim of this study was to investigate the effects of preoperative oral supplementation with branched‐chain amino acids (BCAAs) on postoperative bacteremia after living donor liver transplantation (LDLT) for chronic liver failure. Two hundred thirty‐six patients who underwent adult‐to‐adult LDLT were evaluated in this retrospective study.

Impact of portal venous hemodynamics on indices of liver function and graft regeneration after right lobe living donor liver transplantation

Ting‐Jung Wu, Divya Dahiya, Ching‐Sung Lee, Chen‐Fang Lee, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee – 3 May 2011 – The aim of this study was to evaluate the effects of portal hemodynamics on indices of liver function and graft regeneration in patients after adult right lobe living donor liver transplantation (R‐LDLT). Sixty‐four patients who underwent R‐LDLT and had an uneventful postoperative course were enrolled in this study. The contribution of portal flow was greater to the recipient grafts versus the donor livers (90.74% versus 69.12%, P < 0.0001).

Growth of hepatocellular carcinoma in the regenerating liver

Ji‐Hua Shi, Henrik S. Huitfeldt, Zhen‐He Suo, Pål‐Dag Line – 3 May 2011 – Liver resection and liver transplantation are the treatment modalities with the greatest potential for curing hepatocellular carcinoma (HCC). Tumor recurrence after resection for HCC is, however, a major problem, and an increased rate of recurrence after living donor transplantation versus cadaveric whole liver transplantation has been suggested. Factors involved in liver regeneration may stimulate the growth of occult tumors.

Novel engineered targeted interferon‐gamma blocks hepatic fibrogenesis in mice

Ruchi Bansal, Jai Prakash, Eduard Post, Leonie Beljaars, Detlef Schuppan, Klaas Poelstra – 29 April 2011 – Liver fibrogenesis is a process tightly controlled by endogenous anti‐ and pro‐fibrogenic factors. Interferon gamma (IFNγ) is a potent antifibrogenic cytokine in vitro and might therefore represent a powerful therapeutic entity. However, its poor pharmacokinetics and adverse effects, due to the presence of IFNγ receptors on nearly all cells, prevented its clinical application so far.

Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER‐medicare database

Tania M. Welzel, Barry I. Graubard, Stefan Zeuzem, Hashem B. El‐Serag, Jessica A. Davila, Katherine A. McGlynn – 29 April 2011 – Incidence rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor for HCC and a postulated one for ICC. The magnitude of risk, however, has not been investigated on a population level in the United States. We therefore examined the association between metabolic syndrome and the development of these cancers.

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