Jeremy S. Duffield – 26 November 2011

Liping Liu, Govardhana Rao Yannam, Taichiro Nishikawa, Toshiyuki Yamamoto, Hesham Basma, Ryotaro Ito, Masaki Nagaya, Joyeeta Dutta‐Moscato, Donna B. Stolz, Fenghai Duan, Klaus H. Kaestner, Yoram Vodovotz, Alejandro Soto‐Gutierrez, Ira J. Fox – 23 November 2011 – In advanced cirrhosis, impaired function is caused by intrinsic damage to the native liver cells and from the abnormal microenvironment in which the cells reside. The extent to which each plays a role in liver failure and regeneration is unknown.

Seanthan Senthilnathan, Khairuddin Memon, Robert J. Lewandowski, Laura Kulik, Mary F. Mulcahy, Ahsun Riaz, Frank H. Miller, Vahid Yaghmai, Paul Nikolaidis, Edward Wang, Talia Baker, Michael Abecassis, Al B. Benson, Reed A. Omary, Riad Salem – 23 November 2011 – Although most cancers are considered predominantly systemic processes, this may not hold true for hepatocellular carcinoma (HCC). The literature regarding patterns of progression of HCC (local versus systemic) has been relatively sparse.

Katrin Neumann, Nils Kruse, Balint Szilagyi, Ulrike Erben, Christine Rudolph, Anne Flach, Martin Zeitz, Alf Hamann, Katja Klugewitz – 23 November 2011 – Gut‐activated T cells migrating into the liver can cause extraintestinal manifestations of inflammatory bowel disease. T cells acquire a gut‐homing phenotype dependent on retinoic acid (RA) provided by intestinal dendritic cells (DC). We investigated whether liver antigen‐presenting cells can induce gut tropism supporting an enterohepatic lymphocyte circulation.

Supatsri Sethasine, Dhanpat Jain, Roberto J. Groszmann, Guadalupe Garcia‐Tsao – 23 November 2011 – We have previously shown, in a semiquantitative analysis of liver biopsies showing cirrhosis, that thickness of fibrous septa separating cirrhotic nodules and small size of cirrhotic nodules correlated independently with portal pressure (as determined by the hepatic venous pressure gradient; HVPG) and were independent predictors of the presence of clinically significant portal hypertension (PH).

Kris V. Kowdley, Chia C. Wang, Sue Welch, Henry Roberts, Carol L. Brosgart – 22 November 2011 – Estimates of the prevalence of chronic hepatitis B (CHB) in the United States differ significantly, and the contribution of foreign‐born (FB) persons has not been adequately described. The aim of this study was to estimate the number of FB persons in the United States living with CHB by their country of origin. We performed a systematic review for reports of HBsAg seroprevalence rates in 102 countries (covering PubMed from 1980 to July 2010).

Saifeng Wang, Lipeng Qiu, Xiaoli Yan, Wensong Jin, Yanzhong Wang, Lizhao Chen, Erjie Wu, Xin Ye, George F. Gao, Fusheng Wang, Yu Chen, Zhongping Duan, Songdong Meng – 22 November 2011 – Hepatitis B virus (HBV) causes chronic infection in about 350 million people worldwide. Given the important role of the most abundant liver‐specific microRNA, miR‐122, in hepatic function and liver pathology, here we investigated the potential role and mechanism of miR‐122 in regulating HBV replication.

Soo Mi Kim, Sun‐Hee Leem, In‐Sun Chu, Yun‐Yong Park, Sang Cheol Kim, Sang‐Bae Kim, Eun Sung Park, Jae Yun Lim, Jeonghoon Heo, Yoon Jun Kim, Dae‐Ghon Kim, Ahmed Kaseb, Young Nyun Park, Xin Wei Wang, Snorri S. Thorgeirsson, Ju‐Seog Lee – 22 November 2011 – Clinical application of the prognostic gene expression signature has been delayed due to the large number of genes and complexity of prediction algorithms. In the current study we aimed to develop an easy‐to‐use risk score with a limited number of genes that can robustly predict prognosis of patients with hepatocellular carcinoma (HCC).

Aditya Ambade, Donna Catalano, Arlene Lim, Pranoti Mandrekar – 22 November 2011 – Endotoxin‐mediated proinflammatory cytokines play a significant role in the pathogenesis of acute and chronic liver diseases. Heat shock protein 90 (molecular weight, 90 kDa) (hsp90) functions as an important chaperone of lipopolysaccharide (LPS) signaling and is required for the production of proinflammatory cytokines. We hypothesized that inhibition of hsp90 would prevent LPS‐induced liver injury by decreasing proinflammatory cytokines.

Sumeet K. Asrani, Nicholas F. LaRusso – 22 November 2011