Histological diagnosis of early hepatocellular carcinoma
Morris Sherman – 30 March 2011
p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma
Doris Schneller, Georg Machat, Alexandra Sousek, Verena Proell, Franziska van Zijl, Gudrun Zulehner, Heidemarie Huber, Markus Mair, Markus K. Muellner, Sebastian M.B. Nijman, Robert Eferl, Richard Moriggl, Wolfgang Mikulits – 30 March 2011 – Signal transducer and activator of transcription 3 (Stat3) is activated in a variety of malignancies, including hepatocellular carcinoma (HCC). Activation of Ras occurs frequently at advanced stages of HCC by aberrant signaling through growth factor receptors or inactivation of effectors negatively regulating Ras signaling.
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion
Danijela Petrovic, Zania Stamataki, Eugene Dempsey, Lucy Golden‐Mason, Michael Freeley, Derek Doherty, David Prichard, Catherine Keogh, Jennifer Conroy, Siobhan Mitchell, Yuri Volkov, Jane A. McKeating, Cliona O'Farrelly, Dermot Kelleher, Aideen Long – 30 March 2011 – T cell activation and the resultant production of interleukin (IL‐2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses several mechanisms to evade both the innate and adaptive arms of the immune response.
Efforts at making the diagnosis of acute‐onset autoimmune hepatitis
Keiichi Fujiwara, Shin Yasui, Osamu Yokosuka – 30 March 2011
Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma
Gonzalo Sapisochin, Nicholas Fidelman, John P. Roberts, Francis Y. Yao – 24 March 2011 – Mixed hepatocellular cholangiocarcinoma (HCC‐CC) and intrahepatic cholangiocarcinoma (I‐CC) are increasingly being reported in patients with cirrhosis.
Nonalcoholic fatty liver disease activity score and Brunt's pathologic criteria for the diagnosis of nonalcoholic steatohepatitis: What do they mean and do they agree?
Stefano Ballestri, Amedeo Lonardo, Paola Loria – 24 March 2011
Reply:
Jin‐Kyu Park, Kyu‐Shik Jeong – 24 March 2011
Liver biopsy interpretation in liver cancer
Charles Balabaud – 24 March 2011
Reply:
René Adam, Eric Vibert, Jean‐Charles Duclos‐Vallee, Didier Samuel – 24 March 2011
What is the role of the receptor for advanced glycation end products–ligand axis in liver injury?
Giuseppina Basta, Teresa Navarra, Paolo De Simone, Serena Del Turco, Amalia Gastaldelli, Franco Filipponi – 24 March 2011 – Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis.