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Claude Tayar, Michael D. Kluger, Alexis Laurent, Daniel Cherqui, – 21 March 2011
Telomerase mutation: A genetic risk factor for cirrhosis
Roongruedee Chaiteerakij, Lewis R. Roberts – 21 March 2011
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Marcel Janse, Laetitia E. Lamberts, Lude Franke, Soumya Raychaudhuri, Eva Ellinghaus, Kirsten Muri Boberg, Espen Melum, Trine Folseraas, Erik Schrumpf, Annika Bergquist, Einar Björnsson, Jingyuan Fu, Harm Jan Westra, Harry J.M. Groen, Rudolf S.N. Fehrmann, Joanna Smolonska, Leonard H. van den Berg, Roel A. Ophoff, Robert J. Porte, Tobias J. Weismüller, Jochen Wedemeyer, Christoph Schramm, Martina Sterneck, Rainer Günther, Felix Braun, Severine Vermeire, Liesbet Henckaerts, Cisca Wijmenga, Cyriel Y. Ponsioen, Stefan Schreiber, Tom H. Karlsen, Andre Franke, Rinse K.
Is bacterial DNA a better marker than endotoxin of bacterial translocation in decompensated cirrhosis?
Jiannis Vlachogiannakos, George Daikos, Ulrich Thalheimer, Andrew K. Burroughs, Spiros D. Ladas – 21 March 2011
Delayed‐onset caspase‐dependent massive hepatocyte apoptosis upon fas activation in bak/bax‐deficient mice
Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Shigeomi Shimizu, Yoshihide Tsujimoto, Norio Hayashi – 21 March 2011 – The proapoptotic Bcl‐2 family proteins Bak and Bax serve as an essential gateway to the mitochondrial pathway of apoptosis.
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice
Timea Csak, Angela Dolganiuc, Karen Kodys, Bharath Nath, Jan Petrasek, Shashi Bala, Dora Lippai, Gyongyi Szabo – 21 March 2011 – Mitochondrial dysfunction is a pathogenic feature of nonalcoholic steatohepatitis (NASH). NASH complicates hepatotropic viral disease. The mitochondrial antiviral signaling protein (MAVS) is the adapter of helicase receptors involved in sensing double‐stranded RNA (dsRNA). We hypothesized that impaired MAVS function may contribute to insufficient antiviral response and liver damage in steatohepatitis.
Patients, cells, and organelles: The intersection of science and serendipity
Nicholas F. LaRusso – 16 March 2011
More on vitamin C deficiency in mice and humans
Liang Shen – 16 March 2011
Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV‐infected children
Ángeles Ruiz‐Extremera, José Antonio Muñoz‐Gámez, María Angustias Salmerón‐Ruiz, Paloma Muñoz de Rueda, Rosa Quiles‐Pérez, Ana Gila‐Medina, Jorge Casado, Ana Belén Martín, Laura Sanjuan‐Nuñez, Ángel Carazo, Esther José Pavón, Esther Ocete‐Hita, Josefa León, Javier Salmerón – 16 March 2011 – The vertical transmission of hepatitis C virus (HCV‐VT) is a major route of HCV infection in children, but the risk factors remain incompletely understood. This study analyzed the role of interleukin 28B (IL28B) in HCV‐VT and in the spontaneous clearance of HCV among infected infants.
Electrostatic modifications of the human leukocyte antigen‐DR P9 peptide‐binding pocket and susceptibility to primary sclerosing cholangitis
Johannes R. Hov, Vasilis Kosmoliaptsis, James A. Traherne, Marita Olsson, Kirsten M. Boberg, Annika Bergquist, Erik Schrumpf, J. Andrew Bradley, Craig J. Taylor, Benedicte A. Lie, John Trowsdale, Tom H. Karlsen – 16 March 2011 – The strongest genetic risk factors for primary sclerosing cholangitis (PSC) are found in the human leukocyte antigen (HLA) complex at chromosome 6p21. Genes in the HLA class II region encode molecules that present antigen to T lymphocytes.