Fibrinogen‐γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage

Sujith V. W. Weerasinghe, David S. Moons, Peter J. Altshuler, Yatrik M. Shah, M. Bishr Omary – 27 January 2011 – Fas ligand (FasL)‐mediated hepatocyte apoptosis occurs in the context of acute liver injury that can be accompanied by intravascular coagulation (IC). We tested the hypothesis that analysis of selected protein fractions from livers undergoing apoptosis will shed light on mechanisms that are involved in liver injury that might be amenable to intervention.

Lineage tracing demonstrates no evidence of cholangiocyte epithelial‐to‐mesenchymal transition in murine models of hepatic fibrosis

Andrew S. Chu, Rosalyn Diaz, Jia‐Ji Hui, Kilangsungla Yanger, Yiwei Zong, Gianfranco Alpini, Ben Z. Stanger, Rebecca G. Wells – 27 January 2011 – Whether or not cholangiocytes or their hepatic progenitors undergo an epithelial‐to‐mesenchymal transition (EMT) to become matrix‐producing myofibroblasts during biliary fibrosis is a significant ongoing controversy.

Liver transplantation for propionic acidemia in children

Roshni Vara, Charles Turner, Helen Mundy, Nigel D. Heaton, Mohammed Rela, Giorgina Mieli‐Vergani, Mike Champion, Nedim Hadzic – 25 January 2011 – Propionic acidemia (PA) is a rare inherited disorder of branched chain amino acid metabolism; despite improvements in conventional medical management, the long‐term outcome remains disappointing. Liver transplantation (LT) has been proposed to minimize the risk of further metabolic decompensations and to improve the quality of life. We performed a retrospective review of all children with PA who underwent LT between 1987 and 2008.

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