Altered store operated calcium entry increases cyclic 3′,5′‐adenosine monophosphate production and extracellular signal‐regulated kinases 1 and 2 phosphorylation in polycystin‐2‐defective cholangiocytes

Carlo Spirli, Luigi Locatelli, Romina Fiorotto, Carola M. Morell, Luca Fabris, Tullio Pozzan, Mario Strazzabosco – 10 October 2011 – Mutations in polycystins (PC1 or PC2/TRPP2) cause progressive polycystic liver disease (PLD). In PC2‐defective mice, cyclic 3′,5′‐adenosine monophosphate/ protein kinase A (cAMP/PKA)‐dependent activation of extracellular signal‐regulated kinase/ mammalian target of rapamycin (ERK‐mTOR) signaling stimulates cyst growth.

Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold‐stored, warm ischemia–damaged experimental liver grafts

Pramod Kadaba Srinivasan, Shintaro Yagi, Benedict Doorschodt, Kazuyuki Nagai, Mamdouh Afify, Shinji Uemoto, Rene Tolba – 10 October 2011 – The increasing shortage of donor organs has led to the increasing use of organs from non–heart‐beating donors. We aimed to assess the impact of venous systemic oxygen persufflation (VSOP) supplemented with nitric oxide (NO) gas during the cold storage (CS) of warm ischemia (WI)–damaged experimental liver grafts.

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b–infected null responders

Kazuaki Chayama, Shoichi Takahashi, Joji Toyota, Yoshiyasu Karino, Kenji Ikeda, Hiroki Ishikawa, Hideaki Watanabe, Fiona McPhee, Eric Hughes, Hiromitsu Kumada – 10 October 2011 – Patients with chronic hepatitis C virus (HCV) infection and previous null response to pegylated interferon (Peg‐IFN) and ribavirin (RBV) have limited therapeutic options. HCV genotype 1 is the most common worldwide and the most difficult to treat; genotype 1b is the most common subtype of genotype 1 outside North America.

Antagonism of peripheral hepatic cannabinoid receptor‐1 improves liver lipid metabolism in mice: Evidence from cultured explants

Tony Jourdan, Laurent Demizieux, Joseph Gresti, Louiza Djaouti, Lila Gaba, Bruno Vergès, Pascal Degrace – 10 October 2011 – It is well established that inactivation of the central endocannabinoid system (ECS) through antagonism of cannabinoid receptor 1 (CB1R) reduces food intake and improves several pathological features associated with obesity, such as dyslipidemia and liver steatosis. Nevertheless, recent data indicate that inactivation of peripheral CB1R could also be directly involved in the control of lipid metabolism independently of central CB1R.

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