Utilization of elderly donors in living donor liver transplantation: When more is less?

Murat Dayangac, C. Burcin Taner, Onur Yaprak, Tolga Demirbas, Deniz Balci, Cihan Duran, Yildiray Yuzer, Yaman Tokat – 25 January 2011 – An accepted definition of donor exclusion criteria has not been established for living donor liver transplantation (LDLT). The use of elderly donors to expand the living donor pool raises ethical concerns about donor safety. The aims of this study were (1) the comparison of the postoperative outcomes of living liver donors by age (≥50 versus <50 years) and (2) the evaluation of the impact of the extent of right hepatectomy on donor outcomes.

Liver transplantation for propionic acidemia in children

Roshni Vara, Charles Turner, Helen Mundy, Nigel D. Heaton, Mohammed Rela, Giorgina Mieli‐Vergani, Mike Champion, Nedim Hadzic – 25 January 2011 – Propionic acidemia (PA) is a rare inherited disorder of branched chain amino acid metabolism; despite improvements in conventional medical management, the long‐term outcome remains disappointing. Liver transplantation (LT) has been proposed to minimize the risk of further metabolic decompensations and to improve the quality of life. We performed a retrospective review of all children with PA who underwent LT between 1987 and 2008.

Predictors of cardiovascular events after liver transplantation: A role for pretransplant serum troponin levels

Elizabeth Coss, Kymberly D. S. Watt, Rachel Pedersen, Ross Dierkhising, Julie K. Heimbach, Michael R. Charlton – 20 January 2011 – Cardiovascular complications are major causes of morbidity and mortality after liver transplantation. Identifying candidates at highest risk of postoperative complications is a cornerstone of optimizing outcomes and utility.

Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model

Mahmoud Abu‐Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Niteen Tapuria, Alexander M. Seifalian, Barry J. Fuller, Brian R. Davidson – 20 January 2011 – Ischemic preconditioning of remote organs (RIPC) reduces liver ischemia/reperfusion (IR) injury in the rabbit and rat. Mice are the only species available with a large number of transgenic strains. This study describes development and validation of a mouse model of hindlimb RIPC that attenuates liver IR injury.

Comparison of radiofrequency ablation and transarterial chemoembolization for hepatocellular carcinoma within the Milan criteria: A propensity score analysis

Chia‐Yang Hsu, Yi‐Hsiang Huang, Yi‐You Chiou, Chien‐Wei Su, Han‐Chieh Lin, Rheun‐Chuan Lee, Jen‐Huey Chiang, Teh‐Ia Huo, Fa‐Yauh Lee, Shou‐Dong Lee – 19 January 2011 – Radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) are used to treat hepatocellular carcinoma (HCC). This study was designed to compare the long‐term survival of HCC patients within the Milan criteria who underwent RFA or TACE. In all, 315 RFA patients and 215 TACE patients with HCC within the Milan criteria were analyzed. Propensity scores were generated to select matched patients.

Reticulon 4B (Nogo‐B) is a novel regulator of hepatic fibrosis

Dahai Zhang, Teruo Utsumi, Hui‐Chun Huang, Lili Gao, Panjamaporn Sangwung, Chuhan Chung, Kazunori Shibao, Kohji Okamoto, Koji Yamaguchi, Roberto J. Groszmann, Levente Jozsef, Zhengrong Hao, William C. Sessa, Yasuko Iwakiri – 19 January 2011 – Nogo‐B, also known as Reticulon 4B, plays important roles in vascular injuries. Its function in the liver is not understood. The aim of this study was to characterize Nogo‐B in liver fibrosis and cirrhosis. Nogo‐B distribution was assessed in normal and cirrhotic human liver sections.

Subscribe to