Identifying who is at risk of drug‐induced liver injury: Is human leukocyte antigen specificity the key?
Shivakumar Chitturi, Geoffrey C. Farrell – 19 January 2011
Complementary role of vitamin D deficiency and the interleukin‐28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C
Davide Bitetto, Giovanna Fattovich, Carlo Fabris, Elisa Ceriani, Edmondo Falleti, Ezio Fornasiere, Michela Pasino, Donatella Ieluzzi, Annarosa Cussigh, Sara Cmet, Mario Pirisi, Pierluigi Toniutto – 19 January 2011 – The widely accepted interleukin‐28B (IL‐28B) rs12979860 C/T polymorphism and the more recently proposed vitamin D serum concentration are two novel predictors of the response to antiviral treatment in chronic hepatitis C virus (HCV) infection.
Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver
Mahmoud Abu‐Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Barry Fuller, Alexander Seifalian, Brian Davidson – 19 January 2011 – Hindlimb remote ischemic preconditioning (RIPC) reduces liver ischemia/reperfusion (IR) injury in wild‐type mice. The underlying mechanisms of RIPC are currently unknown. In this study, we investigated the role of endothelial nitric oxide synthase (eNOS) in mediating the protective effects of RIPC.
Assessment of a chloride‐poor versus a chloride‐containing version of a modified histidine‐tryptophan‐ketoglutarate solution in a rat liver transplantation model
Christian D. Fingas, Shengli Wu, Yanli Gu, Jeremias Wohlschlaeger, André Scherag, Uta Dahmen, Andreas Paul, Herbert de Groot, Ursula Rauen – 19 January 2011 – Recent in vitro studies of cold‐induced cell injury have revealed the detrimental effects of extracellular chloride on cold‐stored isolated rat hepatocytes; however, its influence on endothelial cells is beneficial.
Graft rotation and late portal vein complications in pediatric living donor liver transplantation using left‐sided grafts: Long‐term computed tomography observations
Suk‐Bae Moon, Ju‐Ik Moon, Choon‐Hyuk David Kwon, Sung‐Joo Kim, Jeong‐Meen Seo, Jae‐Won Joh, Suk‐Koo Lee – 14 January 2011 – Right‐side rotation of the graft is an uncommon event after pediatric living donor liver transplantation (LDLT) with a left‐sided graft. However, graft rotation might lead to gradual portal vein (PV) stretching and late portal vein complications (PVCs). The goal of this study was to quantify the degree of graft rotation (R) by computed tomography (CT) and to determine the effect of graft rotation on the development of late PVCs.
Critical care of the end‐stage liver disease patient awaiting liver transplantation
James Y. Findlay, Oren K. Fix, Catherine Paugam‐Burtz, Linda Liu, Puneet Sood, Stephen J. Tomlanovich, Jean Emond – 14 January 2011 – Patients with end‐stage liver disease awaiting liver transplantation frequently require intensive care admission and management due to either complications of liver failure or to intercurrent illness, particularly infection. Mortality in such patients is high and the development of an illness necessitating intensive care unit management can influence transplant candidacy.
Transplantation for liver failure in patients with sickle cell disease: Challenging but feasible
Monika Hurtova, Dora Bachir, Ketty Lee, Julien Calderaro, Thomas Decaens, Michael D. Kluger, Elie Serge Zafrani, Daniel Cherqui, Ariane Mallat, Frédéric Galactéros, Christophe Duvoux – 14 January 2011 – Sickle cell disease (SCD) frequently affects the liver; if acute liver failure (ALF) develops, the only potentially effective therapeutic option is liver transplantation (LT). Only 12 patients for whom LT was performed for SCD‐related ALF have been described so far.
Mobilization of hepatic mesenchymal stem cells from human liver grafts
Qiuwei Pan, Suomi M. G. Fouraschen, Fatima S. F. Aerts Kaya, Monique M. Verstegen, Mario Pescatori, Andrew P. Stubbs, Wilfred van IJcken, Antoine van der Sloot, Ron Smits, Jaap Kwekkeboom, Herold J. Metselaar, Geert Kazemier, Jeroen de Jonge, Hugo W. Tilanus, Gerard Wagemaker, Harry L. A. Janssen, Luc J. W. van der Laan – 14 January 2011 – Extensive studies have demonstrated the potential applications of bone marrow–derived mesenchymal stem cells (BM‐MSCs) as regenerative or immunosuppressive treatments in the setting of organ transplantation.
A single‐center experience with biliary reconstruction in retransplantation: Duct‐to‐duct or roux‐en‐Y choledochojejunostomy
Lena Sibulesky, Michael G. Heckman, Dana K. Perry, C. Burcin Taner, Darrin L. Willingham, Justin H. Nguyen – 14 January 2011 – Retransplantation is the only therapy for patients who have a failing liver graft, and it can be technically challenging. Although duct‐to‐duct (DD) biliary reconstruction is considered standard in deceased donor orthotopic whole organ liver transplantation, Roux‐en‐Y (RY) choledochojejunostomy is preferred by most for biliary reconstruction in retransplantation.
Simultaneous liver and kidney transplantation using donation after cardiac death donors: A brief report
John C. LaMattina, Joshua D. Mezrich, Luis A. Fernandez, Anthony M. D'Alessandro, Janet M. Bellingham, Alexandru I. Musat, David P. Foley – 14 January 2011 – Although the use of donation after cardiac death (DCD) donor organs has been shown to be a viable option for liver and kidney transplant recipients, outcomes after simultaneous liver and kidney (SLK) transplantation using DCD donors are less clear. We performed a retrospective analysis of 37 adult, primary SLK transplants performed at our center between January 1, 1998 and December 31, 2008.