Transcription coactivator mediator subunit MED1 Is required for the development of fatty liver in the mouse

Liang Bai, Yuzhi Jia, Navin Viswakarma, Jiansheng Huang, Aurore Vluggens, Nathan E. Wolins, Nadereh Jafari, M. Sambasiva Rao, Jayme Borensztajn, Gongshe Yang, Janardan K. Reddy – 12 January 2011 – Peroxisome proliferator‐activated receptor‐γ (PPARγ), a nuclear receptor, when overexpressed in liver stimulates the induction of adipocyte‐specific and lipogenesis‐related genes and causes hepatic steatosis.

Suppression of innate immunity (natural killer cell/interferon‐γ) in the advanced stages of liver fibrosis in mice

Won‐Il Jeong, Ogyi Park, Yang‐Gun Suh, Jin‐Seok Byun, So‐Young Park, Earl Choi, Ja‐Kyung Kim, Hyojin Ko, Hua Wang, Andrew M. Miller, Bin Gao – 12 January 2011 – Activation of innate immunity (natural killer [NK] cell/interferon‐γ [IFN‐γ]) has been shown to play an important role in antiviral and antitumor defenses as well as antifibrogenesis. However, little is known about the regulation of innate immunity during chronic liver injury.

Hedgehog activity, epithelial‐mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia

Alessia Omenetti, Lee M. Bass, Robert A. Anders, Maria G. Clemente, Heather Francis, Cynthia D. Guy, Shannon McCall, Steve S. Choi, Gianfranco Alpini, Kathleen B. Schwarz, Anna Mae Diehl, Peter F. Whitington – 12 January 2011 – Biliary atresia (BA) is notable for marked ductular reaction and rapid development of fibrosis. Activation of the Hedgehog (Hh) pathway promotes the expansion of populations of immature epithelial cells that coexpress mesenchymal markers and may be profibrogenic.

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