The role of calcium and nitric oxide during liver enzyme release induced by increased physical forces as evidenced in partially hepatectomized rats

Julieta Díaz‐Juárez, Rolando Hernández‐Muñoz – 13 December 2010 – Although increased plasma enzyme activities could be diagnostic for tissue damage, the mechanisms controlling cellular enzyme release remain poorly understood. We found a selective and drastic elevation of serum enzyme activities accompanying rat liver regeneration after partial hepatectomy (PH), apparently controlled by a mechanism dependent on flow‐bearing physical forces. In fact, this study assesses a putative role of calcium mobilization and nitric oxide (NO) production underlying rat liver enzyme release.

MicroRNA‐492 is processed from the keratin 19 gene and up‐regulated in metastatic hepatoblastoma

Julia von Frowein, Philipp Pagel, Roland Kappler, Dietrich von Schweinitz, Adelbert Roscher, Irene Schmid – 13 December 2010 – MicroRNAs (miRNAs) are well‐known regulators of proliferation, apoptosis, and differentiation and are recognized to play an important role in the development of cancers. Here we aimed to identify the functional contribution of miRNAs to the biology of hepatoblastoma (HB), the most common malignant liver tumor in childhood.

Liver transplantation in patients with cystic fibrosis: Analysis of united network for organ sharing data

Manuel Mendizabal, K. Rajender Reddy, James Cassuto, Kim M. Olthoff, Thomas W. Faust, George A. Makar, Elizabeth B. Rand, Abraham Shaked, Peter L. Abt – 13 December 2010 – The improved life expectancy of patients with cystic fibrosis (CF) has led to a change in the impact of liver disease on the prognosis of this population. Liver transplantation has emerged as the procedure of choice for patients with CF and features of hepatic decompensation and for intractable variceal bleeding as a major manifestation.

Patatin‐Like phospholipase domain‐containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

Luca Valenti, MariaGrazia Rumi, Enrico Galmozzi, Alessio Aghemo, Benedetta Del Menico, Stella De Nicola, Paola Dongiovanni, Marco Maggioni, Anna Ludovica Fracanzani, Raffaela Rametta, Massimo Colombo, Silvia Fargion – 13 December 2010 – Steatosis has been reported to negatively influence the natural history of chronic hepatitis C (CHC), but controversy remains over its causal role due to the confounding effect of adiposity, insulin resistance, and diabetes.

Transforming growth factor‐β adaptor, β2‐spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer

Hye Jung Baek, Michael J. Pishvaian, Yi Tang, Tae Hyun Kim, Shaoxian Yang, Majed El Zouhairi, Jon Mendelson, Kirti Shetty, Bhaskar Kallakury, Deborah L. Berry, Kyung Hwan Shin, Bibhuti Mishra, E. Premkumar Reddy, Sang Soo Kim, Lopa Mishra – 13 December 2010 – Transforming growth factor beta (TGF‐β) is an important regulator of cell growth, and loss of TGF‐β signaling is a hallmark of carcinogenesis. The Smad3/4 adaptor protein β2‐spectrin (β2SP) is emerging as a potent regulator of tumorigenesis through its ability to modulate the tumor suppressor function of TGF‐β.

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