Liver phospholipid transfer protein (PLTP) expression with a PLTP‐null background promotes very low‐density lipoprotein production in mice

Amirfarbod Yazdanyar, Xian‐Cheng Jiang – 24 February 2012 – It is known that plasma phospholipid transfer protein (PLTP) activity influences lipoprotein metabolism. The liver is one of the major sites of lipoprotein production and degradation, as well as of PLTP expression. To address the impact of liver‐expressed PLTP on lipoprotein metabolism, we created a mouse model that expresses PLTP in the liver acutely and specifically, with a PLTP‐null background. This approach in mouse model preparations can also be used universally for evaluating the function of many other genes in the liver.

Relationship between sleep problems and health‐related quality of life among pediatric liver transplant recipients

Emily M. Fredericks, Dawn Dore‐Stites, Sheyla Y. Calderon, Andrew Well, Sally J. Eder, John C. Magee, M. James Lopez – 17 February 2012 – Among adult liver transplant recipients (LTRs), sleep disturbances and fatigue are common. Sleep problems following pediatric liver transplantation may contribute to daytime fatigue and lower health‐related quality of life (HRQOL). The aim of this cross‐sectional study was to determine the impact of sleep problems on the HRQOL of pediatric LTRs using validated measures. Participants included 47 LTRs.

Pregnancy outcomes of liver transplant recipients: A systematic review and meta‐analysis

Neha A. Deshpande, Nathan T. James, Lauren M. Kucirka, Brian J. Boyarsky, Jacqueline M. Garonzik‐Wang, Andrew M. Cameron, Andrew L. Singer, Nabil N. Dagher, Dorry L. Segev – 17 February 2012 – Approximately 14,000 women of reproductive age are currently living in the United States after liver transplantation (LT), and another 500 undergo LT each year. Although LT improves reproductive function in women with advanced liver disease, the associated pregnancy outcomes and maternal‐fetal risks have not been quantified in a broad manner.

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