The green tea polyphenol, epigallocatechin‐3‐gallate, inhibits hepatitis C virus entry

Sandra Ciesek, Thomas von Hahn, Che C. Colpitts, Luis M. Schang, Martina Friesland, Jörg Steinmann, Michael P. Manns, Michael Ott, Heiner Wedemeyer, Philip Meuleman, Thomas Pietschmann, Eike Steinmann – 2 December 2011 – Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Current antiviral therapy fails to clear infection in a substantial proportion of cases. Drug development is focused on nonstructural proteins required for RNA replication. Individuals undergoing orthotopic liver transplantation face rapid, universal reinfection of the graft.

Hepatic endoplasmic reticulum stress in obesity: Deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?

Isabelle A. Leclercq, Derrick M. Van Rooyen, Geoffrey C. Farrell – 2 December 2011 – The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response. Chronic activation of ER stress has been shown to have an important role in the development of insulin resistance and diabetes in obesity.

Magnetic resonance imaging of focal liver lesions: Approach to imaging diagnosis

Kathryn J. Fowler, Jeffrey J. Brown, Vamsi R. Narra – 2 December 2011 – This article is a review of magnetic resonance imaging (MRI) of incidental focal liver lesions. This review provides an overview of liver MRI protocol, diffusion‐weighted imaging, and contrast agents. Additionally, the most commonly encountered benign and malignant lesions are discussed with emphasis on imaging appearance and the diagnostic performance of MRI based on a review of the literature. (HEPATOLOGY 2011)

Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: A randomized trial comparing 3‐ and 6‐month periodicities

Jean‐Claude Trinchet, Cendrine Chaffaut, Valérie Bourcier, Françoise Degos, Jean Henrion, Hélène Fontaine, Dominique Roulot, Ariane Mallat, Sophie Hillaire, Paul Cales, Isabelle Ollivier, Jean‐Pierre Vinel, Philippe Mathurin, Jean‐Pierre Bronowicki, Valérie Vilgrain, Gisèle N'Kontchou, Michel Beaugrand, Sylvie Chevret, for the Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire (GRETCH) – 2 December 2011 – Detection of small hepatocellular carcinoma (HCC) eligible for curative treatment is increased by surveillance, but its optimal periodicity is still debated.

Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes‐associated protein–mediated activation

Raquel Urtasun, Maria U. Latasa, Maria I. Demartis, Stella Balzani, Saioa Goñi, Oihane Garcia‐Irigoyen, Maria Elizalde, Maria Azcona, Rosa M. Pascale, Francesco Feo, Paulette Bioulac‐Sage, Charles Balabaud, Jordi Muntané, Jesus Prieto, Carmen Berasain, Matias A. Avila – 2 December 2011 – The identification of molecular mechanisms involved in the maintenance of the transformed phenotype of hepatocellular carcinoma (HCC) cells is essential for the elucidation of therapeutic strategies.

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