Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells

Avidan U. Neumann, Sandra Phillips, Idit Levine, Samreen Ijaz, Harel Dahari, Rachel Eren, Shlomo Dagan, Nikolai V. Naoumov – 26 August 2010 – Antibodies are thought to exert antiviral activities by blocking viral entry into cells and/or accelerating viral clearance from circulation. In particular, antibodies to hepatitis B virus (HBV) surface antigen (HBsAg) confer protection, by binding circulating virus.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf‐dependent and ‐independent manners in Mice

Tetsuhiro Chiba, Atsuyoshi Seki, Ryutaro Aoki, Hitoshi Ichikawa, Masamitsu Negishi, Satoru Miyagi, Hideyuki Oguro, Atsunori Saraya, Akihide Kamiya, Hiromitsu Nakauchi, Osamu Yokosuka, Atsushi Iwama – 26 August 2010 – We previously reported that forced expression of Bmi1 (B lymphoma Moloney murine leukemia virus insertion region 1 homolog) in murine hepatic stem/progenitor cells purified from fetal liver enhances their self‐renewal and drives cancer initiation.

Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA

Zong‐Gen Peng, Bo Fan, Na‐Na Du, Yu‐Ping Wang, Li‐Mei Gao, Ying‐Hong Li, Yu‐Huan Li, Fei Liu, Xue‐Fu You, Yan‐Xing Han, Zhi‐Yun Zhao, Shan Cen, Jian‐Rui Li, Dan‐Qing Song, Jian‐Dong Jiang – 26 August 2010 – Host heat shock cognate 70 (Hsc70) protein is packaged into hepatitis C viral (HCV) particles as a structural component of the virus in the assembly process. It helps HCV RNA release into the cytoplasm in the next infection cycle. The goal of this study is to investigate whether chemically down‐regulating host Hsc70 expression could be a novel strategy to interrupt HCV replication.

Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection

Andrew J. Muir, Mitchell L. Shiffman, Atif Zaman, Boris Yoffe, Andrew de la Torre, Steven Flamm, Stuart C. Gordon, Paul Marotta, John M. Vierling, Juan Carlos Lopez‐Talavera, Kelly Byrnes‐Blake, David Fontana, Jeremy Freeman, Todd Gray, Diana Hausman, Naomi N. Hunder, Eric Lawitz – 26 August 2010 – Interferon lambda 1 (IFN‐λ1) is a type III IFN that produces intracellular responses similar to those of IFN‐α but in fewer cell types because of differences in the receptor distribution pattern, and this could potentially result in an improved safety profile.

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