Liver transplantation using controlled donation after cardiac death donors: An analysis of a large single‐center experience

Hani P. Grewal, Darrin L. Willingham, Justin Nguyen, Winston R. Hewitt, Bucin C. Taner, Danielle Cornell, Barry G. Rosser, Andrew P. Keaveny, Jamie Aranda‐Michel, Raj Satyanarayana, Denise Harnois, Rolland C. Dickson, David J. Kramer, Christopher B. Hughes – 28 August 2009 – The use of donation after cardiac death (DCD) donors may provide a valuable source of organs for liver transplantation. Concerns regarding primary nonfunction (PNF) and intrahepatic biliary stricture (IHBSs) have limited the enthusiasm for their use.

Transplanted endothelial progenitor cells ameliorate carbon tetrachloride–induced liver cirrhosis in rats

Feng Liu, Zhi‐Da Liu, Nan Wu, Xu Cong, Ran Fei, Hong‐Song Chen, Lai Wei – 28 August 2009 – Cirrhosis is the most common end stage of liver diseases, and there are no effective treatment methods. Here we evaluated the effect of endothelial progenitor cell (EPC) transplantation from rat bone marrow (BM) on the development of cirrhosis induced by carbon tetrachloride (CCl4). Ex vivo generated, characterized, and cultivated rat BM–derived EPCs were identified by their vasculogenic properties in vitro.

Serial measurement of Doppler hepatic hemodynamic parameters for the diagnosis of acute rejection after live donor liver transplantation

Hiroyuki Sugimoto, Koichi Kato, Masashi Hirota, Shin Takeda, Hideya Kamei, Taro Nakamura, Tetsuya Kiuchi, Akimasa Nakao – 28 August 2009 – To elucidate the role of Doppler hepatic hemodynamic parameters as surrogate markers of acute rejection (AR) after live donor liver transplantation (LDLT), serial Doppler measurements were prospectively performed during the first 2 weeks after LDLT to compare the longitudinal hepatic hemodynamic changes between patients with histologically proven AR and patients without histologically proven AR.

Toll‐like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury

Justin D. Ellett, Zachary P. Evans, Carl Atkinson, Michael G. Schmidt, Rick G. Schnellmann, Kenneth D. Chavin – 28 August 2009 – Steatotic donors are routinely rejected for transplantation because of their increased rate of primary nonfunction. These grafts are more sensitive to ischemia/reperfusion (I/R) during transplantation. Removal of endotoxin before reperfusion improves liver performance post‐I/R. We hypothesize that the main modality of injury in steatotic livers is toll‐like receptor 4 (TLR4) signaling.

The clinical relevance of the anhepatic phase during liver transplantation

Alexander J. C. IJtsma, Christian S. van der Hilst, Marieke T. de Boer, Koert P. de Jong, Paul M. J. G. Peeters, Robert J. Porte, Maarten J. H. Slooff – 28 August 2009 – This study assesses the relation between the anhepatic phase duration and the outcome after liver transplantation. Of 645 patients who underwent transplantation between 1994 and 2006, 194 were recipients of consecutive adult primary piggyback liver transplants using heart‐beating donors. The anhepatic phase was defined as the time from the physical removal of the liver from the recipient to recirculation of the graft.

Insulin resistance and microalbuminuria are associated with microvascular disease in patients with cirrhosis

Karen L. Krok, Farida Milwalla, Anurag Maheshwari, Rebecca Rankin, Paul J. Thuluvath – 28 August 2009 – Cardiovascular (CV) disease has a significant impact on post–liver transplantation (LT) survival. Finding surrogate markers for occult CV disease would improve CV assessment in the LT evaluation. This study was designed to determine the prevalence of microvascular disease (MVD) and the utility of both microalbuminuria and the homeostatic model for insulin resistance (HOMA‐IR) for assessing the presence of MVD in potential LT recipients.

Long‐term renal function in liver transplant recipients and impact of immunosuppressive regimens (calcineurin inhibitors alone or in combination with mycophenolate mofetil): The TRY study

Svetlana Karie‐Guigues, Nicolas Janus, Faouzi Saliba, Jerome Dumortier, Christophe Duvoux, Yvon Calmus, Richard Lorho, Gilbert Deray, Vincent Launay‐Vacher, Georges‐Philippe Pageaux – 28 August 2009 – The prevalence of renal insufficiency before and at 1, 12, and 60 months after liver transplantation (LTx; primary endpoint) and the changes in the glomerular filtration rate (GFR) at same time points according to the immunosuppressive regimen (coprimary endpoint) were investigated.

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