Markus Reschke, Ingvar Ferby, Ewa Stepniak, Nina Seitzer, David Horst, Erwin F. Wagner, Axel Ullrich – 26 March 2010 – The mitogen‐inducible gene‐6 (mig‐6) is a multi‐adaptor protein implicated in the regulation of the HER family of receptor tyrosine kinases. We have reported recently that mig‐6 is a negative regulator of epidermal growth factor receptor (EGFR)‐dependent skin morphogenesis and tumor formation in vivo. In the liver, ablation of mig‐6 leads to an increase in EGFR protein levels, suggesting that mig‐6 is a negative regulator of EGFR function.

Philip A. Berry, Charalambos G. Antoniades, Julia Wendon – 26 March 2010

Anna Alisi, Nadia Panera, Valerio Nobili – 26 March 2010

Christopher Soll, Pierre‐Alain Clavien – 26 March 2010

Christian Toso, Shaheed Merani, David L. Bigam, A.M. James Shapiro, Norman M. Kneteman – 26 March 2010 – Liver transplantation is an important treatment option for selected patients with nonresectable hepatocellular carcinoma (HCC). Several reports have suggested a lower risk of posttransplant tumor recurrence with the use of sirolimus and a higher one with calcineurin inhibitors, but the selection of an ideal immunosuppression protocol is still a matter of debate.

Beate Appenrodt, Frank Grünhage, Martin G. Gentemann, Lydia Thyssen, Tilman Sauerbruch, Frank Lammert – 26 March 2010 – Spontaneous bacterial peritonitis (SBP), a severe complication in patients with advanced liver cirrhosis, has been attributed to bacterial translocation from the intestine. Variants of the NOD2 (nucleotide‐binding oligomerization domain containing 2) gene have been associated with impaired mucosal barrier function in Crohn disease. We hypothesized that the risk of acquiring SBP is increased in patients with cirrhosis carrying NOD2 variants.

Yoichiro Uchida, Bibo Ke, Maria Cecilia S. Freitas, Haofeng Ji, Danyun Zhao, Elizabeth R. Benjamin, Nader Najafian, Hideo Yagita, Hisaya Akiba, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 26 March 2010 – The T cell immunoglobulin and mucin domain‐containing molecules (TIM) protein family, which is expressed by T cells, plays a crucial role in regulating host adaptive immunity and tolerance. However, its role in local inflammation, such as innate immunity‐dominated organ ischemia–reperfusion injury (IRI), remains unknown.

Nicholas J. Osborne, Lyle C. Gurrin, Katrina J. Allen, Clare C. Constantine, Martin B. Delatycki, Christine E. McLaren, Dorota M. Gertig, Gregory J. Anderson, Melissa C. Southey, John K. Olynyk, Lawrie W. Powell, John L. Hopper, Graham G. Giles, Dallas R. English – 26 March 2010 – The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990.

Matthew Hennig, Michele T. Yip‐Schneider, Sabrina Wentz, Huangbing Wu, S. K. Hekmatyar, Patrick Klein, Navin Bansal, C. Max Schmidt – 26 March 2010 – Hepatocellular carcinoma (HCC) is a common cause of death from solid organ malignancy worldwide. Extracellular signal‐regulated/mitogen‐activated protein kinase kinase (MEK) signaling is a critical growth regulatory pathway in HCC. Targeting MEK with a novel small molecule inhibitor, PD0325901, may inhibit HCC tumorigenesis.

Susanne Knapp, Usama Warshow, Doha Hegazy, Louise Brackenbury, I. Neil Guha, Andrew Fowell, Ann‐Margaret Little, Graeme J. Alexander, William M.C. Rosenberg, Matthew E. Cramp, Salim I. Khakoo – 26 March 2010 – Natural killer cells are a key component in the immune control of viral infections. Their functions are controlled by inhibitory receptors for major histocompatability complex (MHC) class I, including the killer cell immunoglobulin‐like receptors (KIR).