Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantation

Celina M. Yong, Madan Sharma, Victor Ochoa, Freddy Abnousi, John Roberts, Nathan M. Bass, Claus U. Niemann, Stephen Shiboski, Megha Prasad, Mehdi Tavakol, Thomas A. Ports, Gabriel Gregoratos, Yerem Yeghiazarians, Andrew J. Boyle – 28 October 2010 – The optimal preoperative cardiac evaluation strategy for patients with end‐stage liver disease (ESLD) undergoing liver transplantation remains unknown. Patients are frequently referred for cardiac catheterization, but the effects of coronary artery disease (CAD) on posttransplant mortality are also unknown.

Neutrophil gelatinase—Associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation

Andrew J. Portal, Mark J. W. McPhail, Matthew Bruce, Iona Coltart, Andrew Slack, Roy Sherwood, Nigel D. Heaton, Debbie Shawcross, Julia A. Wendon, Michael A. Heneghan – 28 October 2010 – Postoperative acute kidney injury (AKI) increases morbidity and mortality after liver transplantation (LT). Novel methods of assessing AKI including cystatin C (CyC) and neutrophil gelatinase–associated lipocalin (NGAL) have been identified as potential markers of AKI.

Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation

Ricky Harminder Bhogal, Stuart M. Curbishley, Christopher J. Weston, David H. Adams, Simon C. Afford – 28 October 2010 – Increasing evidence shows that reactive oxygen species (ROS) may be critical mediators of liver damage during the relative hypoxia of ischemia/reperfusion injury (IRI) associated with transplant surgery or of the tissue microenvironment created as a result of chronic hepatic inflammation or infection. Much work has been focused on Kupffer cells or liver resident macrophages with respect to the generation of ROS during IRI.

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Mahmoud Abu‐Amara, Shiyu Yang, Niteen Tapuria, Barry J. Fuller, Brian R. Davidson, Alexander M. Seifalian – 28 October 2010

Hypomagnesemia and the risk of new‐onset diabetes after liver transplantation

Steven Van Laecke, Federico Desideri, Anja Geerts, Hans Van Vlierberghe, Frederik Berrevoet, Xavier Rogiers, Roberto Troisi, Bernard de Hemptinne, Raymond Vanholder, Isabelle Colle – 28 October 2010 – New‐onset diabetes after transplantation (NODAT) is a frequent complication after liver transplantation and has a negative impact on both patient and graft survival.

Moderate ascites identifies patients with low model for end‐stage liver disease scores awaiting liver transplantation who have a high mortality risk

Ma Somsouk, Rachel Kornfield, Eric Vittinghoff, John M. Inadomi, Scott W. Biggins – 28 October 2010 – Donor livers are offered to patients with the highest risk of death. How ascites could inform risk models to reduce liver transplant wait‐list mortality is unclear. All adult candidates for primary liver transplantation for cirrhosis without exception points who were registered with the Organ Procurement and Transplantation Network from 2005 to 2007 composed our study cohort.

Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death

Yanjun Shi, Hasibur Rehman, Gary L. Wright, Zhi Zhong – 28 October 2010 – This study investigated the roles of inducible nitric oxide synthase (iNOS) in the failure of rat liver grafts from cardiac death donors (GCDD). Livers were explanted after 30‐minute aorta clamping and implanted after 4‐hour storage in University of Wisconsin solution. The iNOS expression increased slightly in grafts from non–cardiac death donors (GNCDD) but markedly in GCDD.

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