Hepatitis B virus replication in primary macaque hepatocytes: Crossing the species barrier toward a new small primate model

Julie Lucifora, Isabelle E. Vincent, Pascale Berthillon, Tatiana Dupinay, Maud Michelet, Ulrike Protzer, Fabien Zoulim, David Durantel, Christian Trepo, Isabelle Chemin – 23 May 2010 – The development of new anti–hepatitis B virus (HBV) therapies, especially immunotherapeutic approaches, has been limited by the lack of a primate model more accessible than chimpanzees. We have previously demonstrated that sylvanus and cynomolgus macaques are susceptible to in vivo HBV infection after intrahepatic HBV DNA inoculation.

Primary hepatocyte culture supports hepatitis C virus replication: A model for infection‐associated hepatocarcinogenesis

Krishna Banaudha, Jan M. Orenstein, Tamara Korolnek, Georges C. St. Laurent, Takaji Wakita, Ajit Kumar – 23 May 2010 – Analysis of progressive changes in hepatic gene expression that underlie hepatocarcinogenesis following hepatitis C virus (HCV) infection require examination of long‐term cultures of normally differentiating primary human hepatocytes. We report a culture system of primary hepatocytes that support productive replication of infectious HCV.

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