Zinc supplementation reverses alcohol‐induced steatosis in mice through reactivating hepatocyte nuclear factor‐4α and peroxisome proliferator‐activated receptor‐α

Xinqin Kang, Wei Zhong, Jie Liu, Zhenyuan Song, Craig J. McClain, Y. James Kang, Zhanxiang Zhou – 28 September 2009 – Alcoholic steatosis is a fundamental metabolic disorder in the progression of alcoholic liver disease. Zinc deficiency is one of the most consistently observed biochemical/nutritional manifestations of alcoholic liver disease. The purpose of this study is to determine whether dietary zinc supplementation to mice previously exposed to alcohol could reverse alcoholic steatosis.

Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss

Nathan A. Johnson, Toos Sachinwalla, David W. Walton, Kate Smith, Ashley Armstrong, Martin W. Thompson, Jacob George – 28 September 2009 – Weight loss remains the most common therapy advocated for reducing hepatic lipid in obesity and nonalcoholic fatty liver disease. Yet, reduction of body weight by lifestyle intervention is often modest, and thus, therapies which effectively modulate the burden of fatty liver but are not contingent upon weight loss are of the highest practical significance.

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

Anne T. Nies, Hermann Koepsell, Stefan Winter, Oliver Burk, Kathrin Klein, Reinhold Kerb, Ulrich M. Zanger, Dietrich Keppler, Matthias Schwab, Elke Schaeffeler – 28 September 2009 – An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic cation transporters (OCTs) of the solute carrier family 22 (SLC22).

Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen–restricted immune pressure

Andri Rauch, Ian James, Katja Pfafferott, David Nolan, Paul Klenerman, Wendy Cheng, Lindsay Mollison, Geoff McCaughan, Nick Shackel, Gary P. Jeffrey, Ross Baker, Elizabeth Freitas, Isla Humphreys, Hansjakob Furrer, Huldrych F. Günthard, Bernard Hirschel, Simon Mallal, Mina John, Michaela Lucas, Eleanor Barnes, Silvana Gaudieri – 28 September 2009 – Many hepatitis C virus (HCV) infections worldwide are with the genotype 1 and 3 strains of the virus.

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