Olivier de Rougemont, Kuno Lehmann, Pierre‐Alain Clavien – 29 September 2009 – Ischemia and reperfusion lead to injury of the liver. Ischemia‐reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment strategies in clinical use today. Intervention is possible at different time points: during harvesting, during the period of preservation, and during implantation.

J. Christie Heller, Allan V. Prochazka, Gregory T. Everson, Lisa M. Forman – 29 September 2009 – As long‐term survival after liver transplantation increases, metabolic complications are becoming increasingly prevalent. Given concerns about which group of providers should be managing liver recipients and how well metabolic complications are managed, we administered a postal survey to 280 transplant hepatologists to determine attitudes, perceptions, and practice patterns in the management of metabolic complications after transplantation. The response rate was 68.2%.

Yu‐Fan Cheng, Hsin‐You Ou, Leo Leung‐Chit Tsang, Chun‐Yen Yu, Tung‐Liang Huang, Tai‐Yi Chen, Allan Concejero, Chee‐Chien Yong, Chao‐Long Chen – 29 September 2009

Nicholas A. Shackel – 29 September 2009

Paula Buchanan, Nino Dzebisashvili, Krista L. Lentine, David A. Axelrod, Mark A. Schnitzler, Paolo R. Salvalaggio – 29 September 2009 – We examined the relationship between the total cost incurred by liver transplantation (LT) recipients and their Model for End‐Stage Liver Disease (MELD) score at the time of transplant. We used a novel database linking billing claims from a large private payer with the Organ Procurement and Transplantation Network registry. Included were adults who underwent LT from March 2002 through August 2007 (n = 990).

Mario Fernández‐Ruiz, Francisco López‐Medrano, Eva María Romo, Luis María Allende, Juan Carlos Meneu, Yiliam Fundora‐Suárez, Rafael San‐Juan, Manuel Lizasoain, Estela Paz‐Artal, Jose María Aguado – 29 September 2009 – Patients with end‐stage liver disease (ESLD) show a low absolute number of peripheral blood lymphocyte subpopulations (PBLSs). We investigated if the baseline PBLS could categorize orthotopic liver transplantation (OLT) recipients into groups at high or low risk for infection after transplantation.

Ashish Singhal, Neerav Goyal, Vivek Vij Subash Gupta – 29 September 2009

Frédéric Schnell, Erwan Donal, Richard Lorho, Sylvain Lavoué, Arnaud Gacouin, Philippe Compagnon, Karim Boudjema, Philippe Mabo, Yves Le Tulzo, Christophe Camus – 29 September 2009 – Left‐sided heart failure (LHF) after liver transplantation (LT) is rare and poorly understood. We performed a case‐control study. We reviewed the data of all patients with LHF after LT at our center from November 2000 to July 2007. Each case was matched to 1 LT control without LHF for age, sex, date of transplantation, and liver disease. Twenty of 599 patients developed LHF (3.3%).

Markus Selzner, Arash Kashfi, Nazia Selzner, Stuart McCluskey, Paul D. Greig, Mark S. Cattral, Gary A. Levy, Les Lilly, Eberhard L. Renner, George Therapondos, Lesley E. Adcock, David R. Grant, Ian D. McGilvray – 29 September 2009 – We studied the role of donor and recipient age in transplantation/ischemia‐reperfusion injury (TIRI) and short‐ and long‐term graft and patient survival. Eight hundred twenty‐two patients underwent deceased donor liver transplantation, with 197 donors being ≥60 years old.

Randeep Kashyap, Charlotte Ryan, Rajeev Sharma, Manoj K. Maloo, Saman Safadjou, Maureen Graham, David Tretheway, Ashokkumar Jain, Mark Orloff – 29 September 2009 – Traditionally, patients who die with a malignancy have been excluded from donation. However, it has become a common practice to accept organs from donors that have low‐grade tumors or tumors with low metastatic potential. The aim of this study was to analyze our experience with the use of liver grafts from donors with central nervous system (CNS) tumors.