Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization

Yingjun Zhao, Xiaoying Wang, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu, Jia Fan, Xianghuo He – 18 November 2010 – Acetylcholinesterase (ACHE) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. However, the roles and implications of ACHE in hepatocellular carcinoma (HCC) remain elusive.

Epidural analgesia provides better pain management after live liver donation: A retrospective study

Hance Clarke, Tony Chandy, Coimbatore Srinivas, Salima Ladak, Nobuhiko Okubo, Nicholas Mitsakakis, Susan Holtzman, David Grant, Stuart A. McCluskey, Joel Katz – 16 November 2010 – Despite the increase in surgical volumes of live liver donation, there has been very little documentation of the postoperative pain experience.

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

Christopher D. Anderson, Gundumi Upadhya, Kendra D. Conzen, Jianlou Jia, Elizabeth M. Brunt, Venkataswarup Tiriveedhi, Yan Xie, Sabarinathan Ramachandran, Thalachallour Mohanakumar, Nicholas O. Davidson, William C. Chapman – 16 November 2010 – Hepatic steatosis continues to present a major challenge in liver transplantation. These organs have been shown to have increased susceptibility to cold ischemia/reperfusion (CIR) injury in comparison with otherwise comparable lean livers; the mechanisms governing this increased susceptibility to CIR injury are not fully understood.

Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model

Yu‐Xiong Feng, Tao Wang, Yue‐Zhen Deng, Pengyuan Yang, Jing‐Jing Li, Dong‐Xian Guan, Fan Yao, Yin‐Qiu Zhu, Ying Qin, Hui Wang, Nan Li, Meng‐Chao Wu, Hong‐Yang Wang, Xiao‐Fan Wang, Shu‐Qun Cheng, Dong Xie – 12 November 2010 – Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is as high as 70%, and this gravely jeopardizes the therapeutic outcome. Clearly, new approaches are needed for preventing the relapse of this deadly disease.

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

Julia Kozlitina, Eric Boerwinkle, Jonathan C. Cohen, Helen H. Hobbs – 12 November 2010 – Nonalcoholic fatty liver disease (NAFLD) is an escalating health problem that is frequently associated with obesity and insulin resistance. The mechanistic relationship between NAFLD, obesity, and insulin resistance is not well understood.

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