Prevalence of hepatitis E virus infection in liver transplant recipients

Elizabeth B. Haagsma, Hubert G. M. Niesters, Arie P. van den Berg, Annelies Riezebos‐Brilman, Robert J. Porte, Harry Vennema, Johan H. J. Reimerink, Marion P. G. Koopmans – 29 September 2009 – Hepatitis E virus (HEV) infection is known to run a self‐limited course. Recently, chronic hepatitis E has been described in several immunosuppressed patients after solid organ transplantation. The prevalence of HEV infection after transplantation, however, is unknown.

Minimal hepatic encephalopathy is associated with motor vehicle crashes: The reality beyond the driving test

Jasmohan S. Bajaj, Kia Saeian, Christine M. Schubert, Muhammad Hafeezullah, Jose Franco, Rajiv R. Varma, Douglas P. Gibson, Raymond G. Hoffmann, R. Todd Stravitz, Douglas M. Heuman, Richard K. Sterling, Mitchell Shiffman, Allyne Topaz, Sherry Boyett, Debulon Bell, Arun J. Sanyal – 28 September 2009 – Patients with minimal hepatic encephalopathy (MHE) have impaired driving skills, but association of MHE with motor vehicle crashes is unclear. Standard psychometric tests (SPT) or inhibitory control test (ICT) can be used to diagnose MHE.

Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo‐angiogenesis regulation

Antonio Mazzocca, Emilia Fransvea, Gabriela Lavezzari, Salvatore Antonaci, Gianluigi Giannelli – 28 September 2009 – Curative therapies for patients with hepatocellular carcinoma (HCC) are mainly invasive, and with the exception of sorafenib, no medical treatments are available for advanced or metastatic stages of HCC. We investigated the antitumoral effect of blocking the transforming growth factor β (TGF‐β) signaling pathway in HCC with LY2109761, a kinase inhibitor of TGF‐β receptor I kinase.

Mcl‐1 and Bcl‐xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, Takahiro Kodama, Wei Li, Takuya Miyagi, Atsushi Hosui, Hisashi Ishida, Kazuyoshi Ohkawa, Tatsuya Kanto, Naoki Hiramatsu, Xiao‐Ming Yin, Lothar Hennighausen, Tomohide Tatsumi, Norio Hayashi – 28 September 2009 – Anti‐apoptotic members of the Bcl‐2 family, including Bcl‐2, Bcl‐xL, Mcl‐1, Bcl‐w and Bfl‐1, inhibit the mitochondrial pathway of apoptosis. Bcl‐xL and Mcl‐1 are constitutively expressed in the liver.

Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice

Kang Cheng, Daniel Benten, Kuldeep Bhargava, Mari Inada, Brigid Joseph, Christopher Palestro, Sanjeev Gupta – 28 September 2009 – Tracking stem/progenitor cells through noninvasive imaging is a helpful means of assessing the targeting of transplanted cells to specific organs. We performed in vitro and in vivo studies wherein adult human hepatocytes and human fetal liver stem/progenitor cells were labeled with indium‐111 (111In)‐oxine and technetium‐99m (99mTc)‐Ultratag or 99mTc‐Ceretec.

Subscribe to