Barbara A. Wetmore, Dominique J. Brees, Reetu Singh, Paul B. Watkins, Melvin E. Andersen, James Loy, Russell S. Thomas – 23 May 2010 – Serum aminotransferases have been the clinical standard for evaluating liver injury for the past 50‐60 years. These tissue enzymes lack specificity, also tracking injury to other tissues. New technologies assessing tissue‐specific messenger RNA (mRNA) release into blood should provide greater specificity and permit indirect assessment of gene expression status of injured tissue.

Wing‐Kin Syn, Ye Htun Oo, Thiago A. Pereira, Gamze F. Karaca, Youngmi Jung, Alessia Omenetti, Rafal P. Witek, Steve S. Choi, Cynthia D. Guy, Caitlin M. Fearing, Vanessa Teaberry, Fausto E.L. Pereira, David H. Adams, Anna Mae Diehl – 23 May 2010 – Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) progression. Livers normally contain many natural killer T (NKT) cells that produce factors that modulate inflammatory and fibrogenic responses.

Peter V. E. van den Berghe, Roderick H. J. Houwen, Leo W. J. Klomp – 23 May 2010

Tugrul Purnak, Cumali Efe, Yavuz Beyazit, Ersan Ozaslan – 23 May 2010

Ming Bai, Guohong Han, Xingshun Qi, Zhanxin Yin, Daiming Fan – 23 May 2010

Adriana L. Burgueño, Julieta Carabelli, Silvia Sookoian, Carlos J. Pirola – 23 May 2010

Don C. Rockey, Leonard B. Seeff, James Rochon, James Freston, Naga Chalasani, Maurizio Bonacini, Robert J. Fontana, Paul H. Hayashi, for the US Drug‐Induced Liver Injury Network – 23 May 2010 – Drug‐induced liver injury (DILI) is largely a diagnosis of exclusion and is therefore challenging. The US Drug‐Induced Liver Injury Network (DILIN) prospective study used two methods to assess DILI causality: a structured expert opinion process and the Roussel‐Uclaf Causality Assessment Method (RUCAM).

Christian J. Steib, Manfred Bilzer, Mark op den Winkel, Susanne Pfeiler, Anna C. Hartmann, Martin Hennenberg, Burkhard Göke, Alexander L. Gerbes – 23 May 2010 – The mechanisms underlying intrahepatic vasoconstriction are not fully elucidated. Here we investigated the Kupffer cell (KC)‐dependent increase in portal pressure by way of actions of vasoconstrictive cysteinyl leukotrienes (Cys‐LTs). Liver cirrhosis was induced in rats by bile duct ligation (BDL for 4 weeks; controls: sham‐operation) and thioacetamide application (18 weeks).

Hong‐Fang Ji, Liang Shen – 23 May 2010

Na Liu, Hongbo Zhang, Kaichun Wu, Daiming Fan – 23 May 2010