Degree of portal vein thrombosis
Xingshun Qi, Guohong Han, Jianhong Wang, Kaichun Wu, Daiming Fan – 22 October 2009
Differences in betaine‐homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol‐fed mice and rats
Masao Shinohara, Cheng Ji, Neil Kaplowitz – 22 October 2009 – Chronic ethanol infusion resulted in greater serum alanine aminotransferase elevation, lipid accumulation, necroinflammation, and focal hepatic cell death in mice than rats. Mice exhibited a remarkable hyperhomocysteinemia but no increase was seen in rats. Similarly, a high‐methionine low‐folate diet (HMLF) induced less steatosis, serum alanine aminotransferase increase, and hyperhomocysteinemia in rats than in mice.
Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription
Wei‐Dong Chen, Yan‐Dong Wang, Lisheng Zhang, Steven Shiah, Meihua Wang, Fan Yang, Donna Yu, Barry M. Forman, Wendong Huang – 22 October 2009 – Elucidating the mechanism of liver regeneration could lead to life‐saving therapy for a large number of patients, especially elderly patients, after segmental liver transplantation or resection of liver tumors. The forkhead box m1b (Foxm1b) transcription factor is required for normal liver regeneration.
Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka
Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani‐Seiki, Hiroshi Nishina – 22 October 2009 – During vertebrate embryogenesis, the liver develops at a precise location along the endodermal primitive gut tube because of signaling delivered by adjacent mesodermal tissues. Although several signaling molecules have been associated with liver formation, the molecular mechanism that regulates liver specification is still unclear.
Human immunodeficiency virus and liver disease: Conference proceedings
Kenneth E. Sherman, Vincent Soriano, Raymond T. Chung – 22 October 2009
Tumorigenicity of human induced pluripotent stem cells depends on the balance of gene expression between p21 and p53
Hisashi Moriguchi, Raymond T. Chung, Chifumi Sato – 22 October 2009
Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol‐fed cystathionine beta synthase–deficient mouse
Farah Esfandiari, Valentina Medici, Donna H. Wong, Soumia Jose, Maryam Dolatshahi, Eoin Quinlivan, Sanjana Dayal, Steven R. Lentz, Hidekazu Tsukamoto, Yue Hua Zhang, Samuel W. French, Charles H. Halsted – 19 October 2009 – We tested the hypothesis that the pathogenesis of alcoholic liver injury is mediated by epigenetic changes in regulatory genes that result from the induction of aberrant methionine metabolism by ethanol feeding.
An indicator for evaluating the risk of cancerous transformations of human induced pluripotent stem cells
Hisashi Moriguchi, Raymond T. Chung, Chifumi Sato – 19 October 2009
MicroRNA‐dependent regulation of DNA methyltransferase‐1 and tumor suppressor gene expression by interleukin‐6 in human malignant cholangiocytes
Chiara Braconi, Nianyuan Huang, Tushar Patel – 19 October 2009 – Although the inflammation‐associated cytokine interleukin‐6 (IL‐6) has been implicated in cholangiocarcinoma growth, the relationship between IL‐6 and oncogenic changes is unknown. IL‐6 can increase expression of DNA methyltransferase‐1 (DNMT‐1) and epigenetically regulate the expression of several genes, including microRNAs (miRNAs). DNMT‐1 up‐regulation occurs in hepatobiliary cancers and is associated with a poor prognosis.