Thomas A. Kerr, Nicholas O. Davidson – 29 September 2009 – Posttranscriptional regulation of gene expression is increasingly recognized as a model for inherited and acquired disease. Recent work has expanded understanding of the range of mechanisms that regulate several of these distinct steps, including messenger RNA (mRNA) splicing, trafficking, and/or stability. Each of these pathways is implicated in disease pathogenesis, and each represents important avenues for therapeutic intervention.

Geng Chen, Huaizhi Wang, Liping Chen, Shizhong Yang, Shuguang Wang, Ping Bie, Zhanyu Yang, Jiahong Dong – 29 September 2009

Francesco D'Amico, Myron Schwartz, Alessandro Vitale, Parissa Tabrizian, Sasan Roayaie, Swan Thung, Maria Guido, Juan del Rio Martin, Thomas Schiano, Umberto Cillo – 29 September 2009 – The up‐to‐seven (Up‐to‐7) criteria [with 7 being the sum of the size and number of tumors for any given hepatocellular carcinoma (HCC)] have been recently proposed to identify potential candidates for liver transplantation (LT) among patients exceeding the Milan criteria.

Randeep Kashyap, Charlotte Ryan, Rajeev Sharma, Manoj K. Maloo, Saman Safadjou, Maureen Graham, David Tretheway, Ashokkumar Jain, Mark Orloff – 29 September 2009 – Traditionally, patients who die with a malignancy have been excluded from donation. However, it has become a common practice to accept organs from donors that have low‐grade tumors or tumors with low metastatic potential. The aim of this study was to analyze our experience with the use of liver grafts from donors with central nervous system (CNS) tumors.

Markus Selzner, Arash Kashfi, Nazia Selzner, Stuart McCluskey, Paul D. Greig, Mark S. Cattral, Gary A. Levy, Les Lilly, Eberhard L. Renner, George Therapondos, Lesley E. Adcock, David R. Grant, Ian D. McGilvray – 29 September 2009 – We studied the role of donor and recipient age in transplantation/ischemia‐reperfusion injury (TIRI) and short‐ and long‐term graft and patient survival. Eight hundred twenty‐two patients underwent deceased donor liver transplantation, with 197 donors being ≥60 years old.

Frédéric Schnell, Erwan Donal, Richard Lorho, Sylvain Lavoué, Arnaud Gacouin, Philippe Compagnon, Karim Boudjema, Philippe Mabo, Yves Le Tulzo, Christophe Camus – 29 September 2009 – Left‐sided heart failure (LHF) after liver transplantation (LT) is rare and poorly understood. We performed a case‐control study. We reviewed the data of all patients with LHF after LT at our center from November 2000 to July 2007. Each case was matched to 1 LT control without LHF for age, sex, date of transplantation, and liver disease. Twenty of 599 patients developed LHF (3.3%).

Ashish Singhal, Neerav Goyal, Vivek Vij Subash Gupta – 29 September 2009

Mario Fernández‐Ruiz, Francisco López‐Medrano, Eva María Romo, Luis María Allende, Juan Carlos Meneu, Yiliam Fundora‐Suárez, Rafael San‐Juan, Manuel Lizasoain, Estela Paz‐Artal, Jose María Aguado – 29 September 2009 – Patients with end‐stage liver disease (ESLD) show a low absolute number of peripheral blood lymphocyte subpopulations (PBLSs). We investigated if the baseline PBLS could categorize orthotopic liver transplantation (OLT) recipients into groups at high or low risk for infection after transplantation.

Paula Buchanan, Nino Dzebisashvili, Krista L. Lentine, David A. Axelrod, Mark A. Schnitzler, Paolo R. Salvalaggio – 29 September 2009 – We examined the relationship between the total cost incurred by liver transplantation (LT) recipients and their Model for End‐Stage Liver Disease (MELD) score at the time of transplant. We used a novel database linking billing claims from a large private payer with the Organ Procurement and Transplantation Network registry. Included were adults who underwent LT from March 2002 through August 2007 (n = 990).

Nicholas A. Shackel – 29 September 2009