Seong H. Ra, Jeffrey B. Kaplan, Charles R. Lassman – 28 October 2009 – Focal nodular hyperplasia (FNH) has been well characterized in native livers, but to our knowledge, no cases of FNH have been described in liver allografts. We review the clinicopathological features of 6 FNHs identified in 4 patients after orthotopic liver transplantation. There were 3 male patients and 1 female patient ranging in age from 2 to 63 years. The time from transplant to a diagnosis of FNH ranged from 15 to 118 months. Two patients presented with an incidental solitary liver nodule.

Avnish Kumar Seth, Pradhi Nambiar, Ajay Joshi, Ramanathan Ramprasad, Rajendra Choubey, Pankaj Puri, Mandapaka Murthy, Sudeep Naidu, Anupam Saha, Harjinder Bhatoe – 28 October 2009 – Organ donation following brain stem death is infrequent in India. There is no prospective study on prevalence of brain stem death and causes of non‐donation. Consecutive patients admitted to intensive care unit from Sep 2006 to Sep 2008 were studied prospectively. Families of those with brain stem death were approached for organ donation by transplant coordinator. Extensive awareness drive was launched.

Toshihiko Ikegami, Yuichi Masuda, Yasunari Ohno, Atsushi Mita, Akira Kobayashi, Koichi Urata, Yuichi Nakazawa, Shirou Miwa, Yasuhiko Hashikura, Shinichi Miyagawa – 28 October 2009 – We have previously reported that a graft volume (GV) > 30% of the recipient's standard liver volume (SLV) can meet the recipient's metabolic demands. Here we report our experience with adult‐to‐adult living donor liver transplantation using left side grafts < 35% of the recipient's SLV.

Alexis Elias Malavazos, Giulia Gobbo, Roberta Francesca Zelaschi, Emanuele Cereda – 27 October 2009

Luciano Sobrevals, Carlos Rodriguez, José Lorenzo Romero‐Trevejo, Gabor Gondi, Iñaki Monreal, Astrid Pañeda, Nerea Juanarena, Sara Arcelus, Nerea Razquin, Laura Guembe, Gloria González‐Aseguinolaza, Jesús Prieto, Puri Fortes – 27 October 2009 – We investigated whether gene transfer of insulin‐like growth factor I (IGF‐I) to the hepatic tissue was able to improve liver histology and function in established liver cirrhosis.

Komal Ramani, Heping Yang, John Kuhlenkamp, Lauda Tomasi, Hidekazu Tsukamoto, José M. Mato, Shelly C. Lu – 27 October 2009 – Hepatic stellate cell (HSC) activation is an essential event during liver fibrogenesis. Methionine adenosyltransferase (MAT) catalyzes biosynthesis of S‐adenosylmethionine (SAMe), the principle methyl donor. SAMe metabolism generates two methylation inhibitors, methylthioadenosine (MTA) and S‐adenosylhomocysteine (SAH).

Edouard Tuaillon, Anne‐Marie Mondain, Fadi Meroueh, Laure Ottomani, Marie‐Christine Picot, Nicolas Nagot, Philippe Van de Perre, Jacques Ducos – 23 October 2009 – We investigated the performance of dried blood spots (DBS) in hepatitis C virus (HCV) diagnosis using modified commercial tests. Paired DBS and serum samples were collected from 200 patients: 100 patients with anti‐HCV antibodies (anti‐HCV), including 62 patients with detectable serum HCV RNA, and 100 patients without anti‐HCV.

Mehdi Mohamadnejad, Muhammad A. Sohail, Azuma Watanabe, Diane S. Krause, E. Scott Swenson, Wajahat Z. Mehal – 23 October 2009 – Bone marrow–derived mesenchymal stem cells (MSCs) have therapeutic potential in liver injury, but the signals responsible for MSC localization to sites of injury and initiation of differentiation are not known. Adenosine concentration is increased at sites of cellular injury and inflammation, and adenosine is known to signal a variety of cellular changes.

Young Chul Kim, Mi‐Suk Park – 23 October 2009

Iker Uriarte, Jesús M. Banales, Elena Sáez, Fabián Arenas, Ronald P. J. Oude Elferink, Jesús Prieto, Juan F. Medina – 23 October 2009 – Bicarbonate secretion from cholangiocytes is required for appropriate adjustment of primary canalicular bile along the biliary tract. In human and rat cholangiocytes, bicarbonate secretion is mediated by anion exchanger (AE) 2, an electroneutral Na+‐independent Cl−/HCO 3− AE also involved in intracellular pH (pHi) regulation. In Ae2a,b‐deficient mice, pHi is increased in lymphocytes and fibroblasts, whereas it is surprisingly normal in cholangiocytes.