Donor and recipient selection leads to good patient and graft outcomes for right lobe split transplantation versus whole graft liver transplantation in adult recipients

Charbel Sandroussi, Michael Crawford, David S. Lockwood, Patrick Tang, James P. Gallagher, Henry Pleass, Simone I. Strasser, Nicholas A. Shackel, Geoffrey W. McCaughan, Deborah J. Verran – 28 October 2009 – The outcomes of right lobe split (RLS) liver transplantation are variable in adult recipients. This report is an analysis of outcomes of our initial 5‐year experience with the right lobe trisegment split graft.

Intimal dissection of the hepatic artery following transarterial embolization for hepatocellular carcinoma: An intraoperative problem in adult living donor liver transplantation

Tsan‐Shiun Lin, Yuan‐Cheng Chiang, Chao‐Long Chen, Allan M. Concejero, Yu‐Fan Cheng, Chih‐Chi Wang, Shih‐Ho Wang, Yueh‐Wei Liu, Chin‐Hsiang Yang, Chee‐Chien Yong – 28 October 2009 – The objective of this study was to describe the relationship between intimal dissection (ID) in the recipient hepatic artery (HA) and transarterial embolization (TAE) and highlight the reconstructive methods for the different types of ID encountered in living donor liver transplantation (LDLT). Fifty‐four patients with hepatocellular carcinoma underwent LDLT.

Outcome of acute liver failure in the elderly

Frank V. Schiødt, Raymond T. Chung, Michael L. Schilsky, J. Eileen Hay, Erik Christensen, William M. Lee – 28 October 2009 – Older age is considered a poor prognostic factor in acute liver failure (ALF) and may still be considered a relative contraindication for liver transplantation for ALF. We aimed to evaluate the impact of older age, defined as age ≥ 60 years, on outcomes in patients with ALF. One thousand one hundred twenty‐six consecutive prospective patients from the US Acute Liver Failure Study Group registry were studied. The median age was 38 years (range, 15–81 years).

Financial, vocational, and interpersonal impact of living liver donation

Susan Holtzman, Lesley Adcock, Derek A. Dubay, George Therapondos, Arash Kashfi, Sarah Greenwood, Eberhard L. Renner, David R. Grant, Gary A. Levy, Susan E. Abbey – 28 October 2009 – The ability to inform prospective donors of the psychosocial risks of living liver donation is currently limited by the scant empirical literature. The present study was designed to examine donor perceptions of the impact of donation on financial, vocational, and interpersonal life domains and identify demographic and clinical factors related to longer recovery times and greater life interference.

Recurrence of hepatocellular carcinoma and hepatitis B reinfection in hepatitis B surface antigen–positive patients after liver transplantation

Sammy Saab, Melina Yeganeh, Kelvin Nguyen, Francisco Durazo, Steven Han, Hasan Yersiz, Douglas G. Farmer, Leonard I. Goldstein, Myron J. Tong, Ronald W. Busuttil – 28 October 2009 – Hepatitis B virus (HBV) reinfection and recurrence of hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLT) are associated with increased graft failure and reduced patient survival. We evaluated the effects of both HCC recurrence and HBV reinfection on the long‐term survival of these patients after OLT.

Quantitative estimation of the degree of hepatic macrovesicular steatosis in a disease‐free population: A single‐center experience in mainland China

Zuo‐Jin Liu, Jian‐Ping Gong, Lv‐Nan Yan – 28 October 2009 – The aim of this study was to derive a simple equation to enable the extent of hepatic macrovesicular steatosis (HMS) to be predicted quantitatively from data obtained noninvasively and hence avoid unnecessary liver biopsies. One hundred sixty‐seven potential living liver donors and 45 subjects suspected of having nonalcoholic fatty liver disease (NAFLD) underwent percutaneous liver biopsy to evaluate HMS quantitatively.

Efficacy and safety of fully covered self‐expandable metallic stents in biliary complications after liver transplantation: A preliminary study

Mario Traina, Ilaria Tarantino, Luca Barresi, Riccardo Volpes, Salvatore Gruttadauria, Ioannis Petridis, Bruno Gridelli – 28 October 2009 – After liver transplantation, the most common biliary complication is the anastomotic stricture, which is followed by biliary leakage. Studies have focused on the endoscopic treatment of biliary complications in transplanted patients with duct‐to‐duct reconstruction, showing a success rate of 70% to 80% after orthotopic liver transplantation and of 60% after living‐related liver transplantation.

Alcohol use while on the liver transplant waiting list: A single‐center experience

Michelle Carbonneau, Louise A. Jensen, Vincent G. Bain, Karen Kelly, Glenda Meeberg, Puneeta Tandon – 28 October 2009 – Alcoholic liver disease (ALD) is a leading indication for liver transplantation. Our center has randomly checked blood alcohol levels (BALs) in ALD patients on the waiting list since 2004. We aimed to identify the incidence and predictors of inactivation on the transplant list due to alcohol use and to determine the utility of BAL‐screening in this process.

Extended bile duct resection liver and transplantation in patients with hilar cholangiocarcinoma: Long‐term results

Daniel Seehofer, Armin Thelen, Ulf P. Neumann, Winfried Veltzke‐Schlieker, Timm Denecke, Carsten Kamphues, Johann Pratschke, Sven Jonas, Peter Neuhaus – 28 October 2009 – For patients with irresectable hilar cholangiocarcinoma, liver transplantation (LT) is currently being reassessed because of promising data for neoadjuvant radiochemotherapy. For increased radicality, hepatectomy in combination with pancreatic head resection [extended bile duct resection (EBDR)] was performed for irresectable hilar cholangiocarcinoma during our initial experience.

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