M. Isabel Lucena, Elena García‐Martín, Raúl J. Andrade, Carmen Martínez, Camilla Stephens, Jhon D. Ruiz, Eugenia Ulzurrun, M. Carmen Fernandez, Manuel Romero‐Gomez, Augustin Castiella, Ramon Planas, José Antonio Durán, Ana Melcón De Dios, Carlos Guarner, German Soriano, Yolanda Borraz, José A. G. Agundez – 23 June 2010 – Drug‐induced liver injury (DILI) susceptibility has a potential genetic basis.

Hong‐Min Ni, Catherine J. Baty, Na Li, Wen‐Xing Ding, Wentao Gao, Min Li, Xiaoyun Chen, Jianjie Ma, George K. Michalopoulos, Xiao‐Ming Yin – 23 June 2010 – BH3‐interacting domain death agonist (Bid), a BH3‐only B cell lymphoma 2 family molecule, is generally known for its importance in activating the mitochondrial apoptosis pathway after death receptor engagement, particularly in hepatocytes. However, Bid also promotes hepatocyte proliferation during liver regeneration and carcinogenesis.

Tobias J. Weismüller, Michael P. Manns, Christian P. Strassburg – 23 June 2010

Yucel Ustundag, Omer Topalak – 23 June 2010

Marc Lutgehetmann, Tassilo Volz, Anne Köpke, Tim Broja, Eike Tigges, Ansgar W. Lohse, Eberhard Fuchs, John M. Murray, Joerg Petersen, Maura Dandri – 23 June 2010 – Chronic hepatitis B virus (HBV) infection is maintained by the presence of covalently closed circular DNA (cccDNA), the template of viral transcription and replication. In quiescent hepatocytes, cccDNA is a stable molecule that can persist throughout the hepatocyte lifespan.

Cyrill Géraud, Kai Schledzewski, Alexandra Demory, Diana Klein, Miriam Kaus, Francis Peyre, Carsten Sticht, Konstantin Evdokimov, Shun Lu, Astrid Schmieder, Sergij Goerdt – 23 June 2010 – Liver sinusoidal endothelium (LSEC) is a prime example of organ‐specific microvascular differentiation and functions. Disease‐associated capillarization of LSEC in vivo and dedifferentiation of LSEC in vitro indicate the importance of the hepatic microenvironment.

Akif Altinbas, Fuat Ekiz, Osman Yuksel – 23 June 2010

Gin‐Ho Lo, Wen‐Chi Chen, Huay‐Min Wang, Ching‐Chang Lee – 23 June 2010 – Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high‐risk esophageal varices but without a bleeding history were considered for enrolment. Eligible patients were randomized to receive band ligation plus nadolol (Combined group, 70 patients) or nadolol alone (Nadolol group, 70 patients). In the Combined group multiligators were applied.

Marco Antonio Montes‐Cano, José Raúl García‐Lozano, Cristina Abad‐Molina, Manuel Romero‐Gómez, Natalia Barroso, José Aguilar‐Reina, Antonio Núñez‐Roldán, María Francisca González‐Escribano – 23 June 2010 – Genetic host factors may modify the course of the hepatitis C virus (HCV) infection. Very recently, a genome‐wide scan that reported association of the IL28B locus with response to treatment in HCV infection was published.

Guo‐Ming Shi, Ai‐Wu Ke, Jian Zhou, Xiao‐Ying Wang, Yang Xu, Zhen‐Bin Ding, Ranjan Prasad Devbhandari, Xiao‐Yong Huang, Shuang‐Jian Qiu, Ying‐Hong Shi, Zhi Dai, Xin‐Rong Yang, Guo‐Huan Yang, Jia Fan – 23 June 2010 – Tetraspanin CD151 is involved in several pathological activities associated with tumor progression, including neoangiogenesis. However, the role and molecular mechanism of CD151 in the neoangiogenesis of hepatocellular carcinoma (HCC) remain enigmatic.