Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation

Brenda M. Bosma, Herold J. Metselaar, Jeroen H. Gerrits, Nicole M. van Besouw, Shanta Mancham, Zwier M. A. Groothuismink, Patrick P. C. Boor, Luc J. W. van der Laan, Hugo W. Tilanus, Ernst J. Kuipers, Jaap Kwekkeboom – 28 October 2009 – It is thought, but there is no evidence, that myeloid dendritic cells (MDCs) of donor origin migrate into the recipient after clinical organ transplantation and sensitize the recipient's immune system by the direct presentation of donor allo‐antigens.

Endoscopic variceal ligation for primary prophylaxis of esophageal variceal hemorrhage in pre–liver transplant patients

Eu Jin Lim, Paul J. Gow, Peter W. Angus – 28 October 2009 – Endoscopic variceal ligation (EVL) is widely used to prevent esophageal variceal bleeding in patients with advanced cirrhosis. However, the safety and efficacy of EVL in this setting have not been clearly established. This study included 300 adult patients with cirrhosis on our liver transplant waitlist who underwent upper gastrointestinal endoscopy. Esophageal varices deemed to be at high risk of bleeding were banded until eradication or transplantation.

Survival of Clostridium perfringens sepsis in a liver transplant recipient

Geraldine C. Diaz, Thomas Boyer, John F. Renz – 28 October 2009 – Clostridium perfringens sepsis following orthotopic liver transplantation (OLT) is a rare but reported complication that historically results in mortality or emergent retransplantation (ReTx).1–7 Complications from C. perfringens emphysematous gastritis have contributed to the death of a healthy live liver donor as well.8 Herein, we describe the first documented survivor of C. perfringens sepsis following OLT managed without laparotomy or emergent ReTx. Liver Transpl 15:1469–1472, 2009. © 2009 AASLD.

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