Laura N. Cruz, Mateus T. Guerra, Emma Kruglov, Albert Mennone, Celia R. S. Garcia, Ju Chen, Michael H. Nathanson – 23 June 2010 – Multidrug resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion secretion into bile. Mrp2 activity is regulated by insertion into the plasma membrane; however, the factors that control this are not understood. Calcium (Ca2+) signaling regulates exocytosis of vesicles in most cell types, and the type II inositol 1,4,5‐triphosphate receptor (InsP3R2) regulates Ca2+ release in the canalicular region of hepatocytes.

Hua‐Fen Chen, Peter Chen, Chung‐Yi Li – 23 June 2010 – We prospectively investigated 615,532 diabetic patients and 614,871 age‐matched and sex‐matched control subjects selected from National Health Insurance claims for malignant neoplasms of liver and biliary tract (International Statistical Classification of Diseases and Related Health Problems, 9th edition, codes 155 and 156, respectively) between 2000 and 2006. The person‐year approach with Poisson assumption was used to estimate the hazard rates.

Shannon Glaser, Ian P. Lam, Antonio Franchitto, Eugenio Gaudio, Paolo Onori, Billy K. Chow, Candace Wise, Shelley Kopriva, Julie Venter, Mellanie White, Yoshiyuki Ueno, David Dostal, Guido Carpino, Romina Mancinelli, Wendy Butler, Valorie Chiasson, Sharon DeMorrow, Heather Francis, Gianfranco Alpini – 23 June 2010 – During bile duct ligation (BDL), the growth of large cholangiocytes is regulated by the cyclic adenosine monophosphate (cAMP)/extracellular signal‐regulated kinase 1/2 (ERK1/2) pathway and is closely associated with increased secretin receptor (SR) expression.

Gyongyi Szabo – 23 June 2010

Robert C. Huebert, Meher M. Vasdev, Uday Shergill, Amitava Das, Bing Q. Huang, Michael R. Charlton, Nicholas F. LaRusso, Vijay H. Shah – 23 June 2010 – Increasing evidence suggests that hepatic fibrosis and pathological angiogenesis are interdependent processes that occur in parallel. Endothelial cell invasion is requisite for angiogenesis, and thus studies of the mechanisms governing liver endothelial cell (LEC) invasion during cirrhosis are of great importance.

Valerio Nobili, Giorgio Bedogni, Anna Alisi, Carlo Agostoni – 23 June 2010

Herbert L. Bonkovsky, Richard W. Lambrecht, Deepa Naishadham – 23 June 2010

Ann M. Thomas, Steven N. Hart, Bo Kong, Jianwen Fang, Xiao‐bo Zhong, Grace L. Guo – 23 June 2010

Ana Blas‐García, Nadezda Apostolova, Daniel Ballesteros, Daniel Monleón, Jose M. Morales, Milagros Rocha, Victor M. Victor, Juan V. Esplugues – 23 June 2010 – Efavirenz (EFV) is a non‐nucleoside reverse transcriptase inhibitor (NNRTI) widely used in human immunodeficiency virus (HIV) infection therapy. It has been associated with hepatotoxic effects and alterations in lipid and body fat composition.

Armando Tripodi, Massimo Primignani, Laura Lemma, Veena Chantarangkul, Alessandra Dell'Era, Francesca Iannuzzi, Alessio Aghemo, Pier Mannuccio Mannucci – 23 June 2010 – Patients with cirrhosis possess an imbalance in procoagulant versus anticoagulant activity due to increased factor VIII and decreased protein C. This imbalance can be detected by thrombin‐generation assays performed in the presence/absence of thrombomodulin (predicate assay) that are not readily available in clinical laboratories.