Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients

Sven Pischke, Pothakamuri V. Suneetha, Christine Baechlein, Hannelore Barg‐Hock, Albert Heim, Nassim Kamar, Jerome Schlue, Christian P. Strassburg, Frank Lehner, Regina Raupach, Birgit Bremer, Peter Magerstedt, Markus Cornberg, Frauke Seehusen, Wolfgang Baumgaertner, Juergen Klempnauer, Jacques Izopet, Michael P. Manns, B. Grummer, Heiner Wedemeyer – 28 October 2009 – Hepatitis E virus (HEV) infection induces self‐limiting liver disease in immunocompetent individuals. Cases of chronic hepatitis E have recently been identified in organ transplant recipients.

Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4+CD25+CD45RO+IL‐7rαhigh T cells

Donatella Ciuffreda, Laura Codarri, Leo Buhler, Laure Vallotton, Emiliano Giostra, Gilles Mentha, Philippe Morel, Giuseppe Pantaleo, Manuel Pascual – 28 October 2009 – The expression of interleukin 7 receptor alphahigh (IL‐7Rαhigh) discriminates between activated CD25+CD45RO+CD4+ T cells [IL‐7Rαhigh and forkhead box P3–negative (FoxP3−)] and regulatory T cells (IL‐7Rαlow and FoxP3+). The IL‐7RαhighCD25+CD45RO+CD4+FoxP3− T cell population has been shown to be expanded in the blood and tissues of patients after kidney transplantation and to contain alloreactive T cells (activated T cells).

Simplifying hepatic venous outflow reconstruction in sequential living donor liver transplantation

See Ching Chan, Chung Mau Lo, Kelvin K. Ng, Kenneth S. Chok, Sheung Tat Fan – 28 October 2009 – The native liver of a familial amyloidotic polyneuropathy recipient who undergoes living donor liver transplantation used as a graft for sequential liver transplantation does not include the inferior vena cava. Implantation of this whole liver graft to a second recipient could be simplified by borrowing the experience from right liver living donor liver transplantation.

Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small‐for‐size syndrome

Dympna M. Kelly, Xiaocheng Zhu, Hiroaki Shiba, Samuel Irefin, Loris Trenti, Andrei Cocieru, Teresa Diago, Lian Fu Wang, Cristiano Quintini, Zhong Chen, Joan Alster, Shunichi Nakagawa, Charles Miller, Anthony Demetris, John J. Fung – 28 October 2009 – The aim of the study is to define the role of the HABR in the pathophysiology of the SFS liver graft and to demonstrate that restoration of hepatic artery flow (HAF) has a significant impact on outcome and improves survival.

Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation

Brenda M. Bosma, Herold J. Metselaar, Jeroen H. Gerrits, Nicole M. van Besouw, Shanta Mancham, Zwier M. A. Groothuismink, Patrick P. C. Boor, Luc J. W. van der Laan, Hugo W. Tilanus, Ernst J. Kuipers, Jaap Kwekkeboom – 28 October 2009 – It is thought, but there is no evidence, that myeloid dendritic cells (MDCs) of donor origin migrate into the recipient after clinical organ transplantation and sensitize the recipient's immune system by the direct presentation of donor allo‐antigens.

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