HuR regulates gap junctional intercellular communication by controlling β‐catenin levels and adherens junction integrity

Niloofar Ale‐Agha, Stefanie Galban, Christiane Sobieroy, Kotb Abdelmohsen, Myriam Gorospe, Helmut Sies, Lars‐Oliver Klotz – 29 October 2009 – Gap junctional intercellular communication (GJIC) plays a critical role in the regulation of tissue homeostasis and carcinogenesis and is modulated by the levels, subcellular localization, and posttranslational modification of gap junction proteins, the connexins (Cx). Here, using oval cell‐like rat liver epithelial cells, we demonstrate that the RNA‐binding protein HuR promotes GJIC through two mechanisms.

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