Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders

Vinod K. Rustgi, William M. Lee, Eric Lawitz, Stuart C. Gordon, Nezam Afdhal, Fred Poordad, Herbert L. Bonkovsky, Leif Bengtsson, Gurudatt Chandorkar, Matthew Harding, Lindsay McNair, Molly Aalyson, John Alam, Robert Kauffman, Shahin Gharakhanian, John G.

Disruptions of occludin and claudin‐5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

Feng Chen, Norifumi Ohashi, Wensheng Li, Christopher Eckman, Justin H. Nguyen – 20 November 2009 – Brain edema in acute liver failure (ALF) remains lethal. The role of vasogenic mechanisms of brain edema has not been explored. We previously demonstrated that matrix metalloproteinase‐9 (MMP‐9) contributes to the pathogenesis of brain edema. Here, we show that MMP‐9 mediates disruptions in tight junction (TJ) proteins in vitro and in brains of mice with ALF.

Role of β3‐adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis

Jonel Trebicka, Martin Hennenberg, Andrea Schulze Pröbsting, Wim Laleman, Sabine Klein, Michaela Granzow, Frederik Nevens, Johan Zaagsma, Jörg Heller, Tilman Sauerbruch – 20 November 2009 – Increased intrahepatic resistance and splanchnic blood flow cause portal hypertension in liver cirrhosis. Nonselective β‐adrenoceptor (β‐AR) antagonists have beneficial effects on hyperdynamic circulation and are in clinical use. In this context, the role of the β3‐AR is undefined. Here we investigated their expression and role in portal hypertension in patients and rats with liver cirrhosis.

Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism

Valérie Haurie, Ludovic Ménard, Alexandra Nicou, Christian Touriol, Philippe Metzler, Jérémy Fernandez, Danièle Taras, Patrick Lestienne, Charles Balabaud, Paulette Bioulac‐Sage, Hervé Prats, Jessica Zucman‐Rossi, Jean Rosenbaum – 20 November 2009 – Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity. We found that Reptin was up‐regulated in hepatocellular carcinoma (HCC) and that down‐regulation of Reptin led to growth arrest.

In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice

Evgeny Chichelnitskiy, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Anja Ziegler, Anna Kleiman, Alexander Rauch, Jan Tuckermann, Stephan Herzig – 20 November 2009 – In mammals, proper maintenance of blood glucose levels within narrow limits is one of the most critical prerequisites for healthy energy homeostasis and body function. Consequently, hyper‐ and hypoglycemia represent hallmarks of severe metabolic pathologies, including type II diabetes and acute sepsis, respectively.

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