What is the real gain after liver transplantation?
James Neuberger – 29 October 2009 – Key Points
Comment on the PROVE1 and PROVE2 clinical trials: “I was taking a picture of rapid virological response with telaprevir, but the background is unfocused!”
Leonardo Baiocchi, Ilaria Lenci, Marco Carbone, Mario Angelico – 29 October 2009
Reply:
Neal D. Freedman, Teresa M. Curto, James E. Everhart – 29 October 2009
Farnesyltransferase inhibitors reduce ras activation and ameliorate acetaminophen‐induced liver injury in mice
Banishree Saha, Dipankar Nandi – 29 October 2009 – Hepatotoxicity due to overdose of the analgesic and antipyretic acetaminophen (APAP) is a major cause of liver failure in adults. To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400–500 mg/kg). Ras–guanosine triphosphate (GTP) is induced early and in an oxidative stress‐dependent manner.
The β2 integrin CD11b attenuates polyinosinic:Polycytidylic acid–induced hepatitis by negatively regulating natural killer cell functions
Minggang Zhang, Yanmei Han, Chaofeng Han, Sheng Xu, Yan Bao, Zhubo Chen, Yan Gu, Dajing Xia, Xuetao Cao – 29 October 2009 – The β2 integrins play a key role in inflammation and immune responses. The β2 integrin CD11b has been shown recently to be important in the maintenance of tolerance; however, the underlying mechanisms remain to be fully understood. Natural killer (NK) cells are an important effector of innate immunity but are also a regulator of adaptive immune response.
Identification of androgen response elements in the enhancer I of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B
Sheng‐Han Wang, Shiou‐Hwei Yeh, Wei‐Hsiang Lin, Hurng‐Yi Wang, Ding‐Shinn Chen, Pei‐Jer Chen – 29 October 2009 – Hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) occurs more often in men than in women. Male HBV carriers usually have higher viral loads, which is a well‐known risk factor for HCC. Whether and how the male androgen axis regulates HBV transcription and replication is investigated here. We used HBV transgenic mice to evaluate any sex disparity of serum hepatitis B surface antigen and HBV titers as well as the castration effect on this disparity.
The myth of occult hepatitis C infection
Philippe Halfon, Michele Martinot‐Peignoux, Patrice Cacoub – 29 October 2009
Quality of life for pediatric liver recipients
Estella M. Alonso – 29 October 2009 – Key Points
Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
Muh‐Hwa Yang, Chih‐Li Chen, Gar‐Yang Chau, Shih‐Hwa Chiou, Chien‐Wei Su, Teh‐Ying Chou, Wei‐Li Peng, Jaw‐Ching Wu – 29 October 2009 – The epithelial‐mesenchymal transition (EMT) is critical for induction of invasiveness and metastasis of human cancers. In this study we investigated the expression profiles of the EMT markers, the relationship between EMT markers and patient/tumor/viral factors, and the interplay between major EMT regulators in human hepatocellular carcinoma (HCC).
Inhibition of extracellular signal‐regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats
Wei Zhong, Wei‐Feng Shen, Bei‐Fang Ning, Ping‐Fang Hu, Yong Lin, Hai‐Yan Yue, Chuan Yin, Jun‐Liang Hou, Yue‐Xiang Chen, Jun‐Ping Zhang, Xin Zhang, Wei‐Fen Xie – 29 October 2009 – Extracellular signal‐regulated kinase 1 (ERK1) is a critical part of the mitogen‐activated protein kinase signal transduction pathway, which is involved in hepatic fibrosis. However, the effect of down‐regulation of ERK1 on hepatic fibrosis has not been reported. Here, we induced hepatic fibrosis in rats with dimethylnitrosamine administration or bile duct ligation.