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Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy

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Jasmohan S. Bajaj, James B. Wade, Arun J. Sanyal – 20 November 2009

Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism

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Valérie Haurie, Ludovic Ménard, Alexandra Nicou, Christian Touriol, Philippe Metzler, Jérémy Fernandez, Danièle Taras, Patrick Lestienne, Charles Balabaud, Paulette Bioulac‐Sage, Hervé Prats, Jessica Zucman‐Rossi, Jean Rosenbaum – 20 November 2009 – Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity. We found that Reptin was up‐regulated in hepatocellular carcinoma (HCC) and that down‐regulation of Reptin led to growth arrest.

In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice

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Evgeny Chichelnitskiy, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Anja Ziegler, Anna Kleiman, Alexander Rauch, Jan Tuckermann, Stephan Herzig – 20 November 2009 – In mammals, proper maintenance of blood glucose levels within narrow limits is one of the most critical prerequisites for healthy energy homeostasis and body function. Consequently, hyper‐ and hypoglycemia represent hallmarks of severe metabolic pathologies, including type II diabetes and acute sepsis, respectively.