Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course

Juan F. Gallegos‐Orozco, Amir Yosephy, Brie Noble, Bashar A. Aqel, Thomas J. Byrne, Elizabeth J. Carey, David D. Douglas, David Mulligan, Adyr Moss, Giovanni de Petris, James W. Williams, Jorge Rakela, Hugo E. Vargas – 24 November 2009 – Our aim was to assess long‐term survival in patients transplanted for HCV‐related end‐stage liver disease (ESLD) and evaluate potentially modifiable predictors of survival. We performed a retrospective analysis of adult liver transplants (LT) at our institution for HCV‐related ESLD since the program's inception.

Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease

Vishal Bhagat, Ayse L. Mindikoglu, Carmine G. Nudo, Eugene R. Schiff, Andreas Tzakis, Arie Regev – 24 November 2009 – Nonalcoholic steatohepatitis (NASH) is becoming a common cause of liver cirrhosis requiring liver transplantation (LT). Cardiovascular complications related to metabolic syndrome and NASH recurrence in the transplanted liver may affect the outcome of LT in these patients. We compared the outcomes of LT for NASH cirrhosis and alcoholic cirrhosis (ETOH) in a large transplant center.

Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis

Shahid M. Malik, Michael E. deVera, Paulo Fontes, Obaid Shaikh, Eizaburo Sasatomi, Jawad Ahmad – 24 November 2009 – Recurrence of the original disease following liver transplantation is not uncommon and can lead to graft failure. There are limited data on recurrent fatty liver disease following liver transplantation. The aim of this study was to determine the incidence of recurrent fatty liver disease in patients with biopsy‐proven nonalcoholic steatohepatitis, its effect on survival, and whether there are any predictive factors for recurrence.

A graft to body weight ratio less than 0.8 does not exclude adult‐to‐adult right‐lobe living donor liver transplantation

Markus Selzner, Arash Kashfi, Mark S. Cattral, Nazia Selzner, Paul D. Greig, Les Lilly, Ian D. McGilvray, George Therapondos, Lesley E. Adcock, Anand Ghanekar, Gary A. Levy, Eberhard L. Renner, David R. Grant – 24 November 2009 – Many centers require a minimal graft to body weight ratio (GBWR) ≥ 0.8 as an arbitrary threshold to proceed with right‐lobe living donor liver transplantation (RL‐LDLT), and there is often hesitancy about transplanting lower volume living donor (LD) liver grafts into sicker patients.

Effect of pretransplant serum creatinine on the survival benefit of liver transplantation

Pratima Sharma, Douglas E. Schaubel, Mary K. Guidinger, Robert M. Merion – 24 November 2009 – More candidates with creatinine levels ≥ 2 mg/dL have undergone liver transplantation (LT) since the implementation of Model for End‐Stage Liver Disease (MELD)–based allocation. These candidates have higher posttransplant mortality. This study examined the effect of serum creatinine on survival benefit among candidates undergoing LT. Scientific Registry of Transplant Recipients data were analyzed for adult LT candidates listed between September 2001 and December 2006 (n = 38,899).

Routine microsurgical biliary reconstruction decreases early anastomotic complications in living donor liver transplantation

Tsan‐Shiun Lin, Allan M. Concejero, Chao‐Long Chen, Yuan‐Cheng Chiang, Chih‐Chi Wang, Shih‐Ho Wang, Yueh‐Wei Liu, Chin‐Hsiang Yang, Chee‐Chien Yong, Bruno Jawan, Yu‐Fan Cheng – 24 November 2009 – Biliary reconstruction using a microsurgical technique in living donor liver transplantation was routinely performed on 88 grafts primarily transplanted into 85 patients. All procedures were performed under a microscope by a single microsurgeon. Except for biliary atresia and Alagille syndrome, duct‐to‐duct reconstruction was performed. Stents were not used.

Subscribe to