Differential transcriptome patterns for acute cellular rejection in recipients with recurrent hepatitis C after liver transplantation

Tadafumi Asaoka, Tomoaki Kato, Shigeru Marubashi, Keizo Dono, Naoki Hama, Hidenori Takahashi, Shogo Kobayashi, Yutaka Takeda, Ichiro Takemasa, Hiroaki Nagano, Hideo Yoshida, Phillip Ruiz, Andreas G. Tzakis, Kenichi Matsubara, Morito Monden, Yuichiro Doki, Masaki Mori – 24 November 2009 – Histopathological evaluation of the liver via biopsy remains the standard procedure for the diagnosis of both acute cellular rejection (ACR) and recurrent hepatitis C (RHC) after liver transplantation.

Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors

Zoe A. Stewart, Jayme E. Locke, Dorry L. Segev, Nabil N. Dagher, Andrew L. Singer, Robert A. Montgomery, Andrew M. Cameron – 24 November 2009 – Hepatic artery thrombosis (HAT) is the most common vascular complication after liver transplantation; it has been reported to occur in 2% to 5% of liver transplant recipients. Most reports of HAT in the literature describe single‐center series with small numbers of patients and lack the power to definitively identify nontechnical risk factors.

Liver transplantation and pancreatic resection: A single‐center experience and a review of the literature

John A. Stauffer, Jeffery L. Steers, Hugo Bonatti, Marjorie K. Dougherty, Jaime Aranda‐Michel, Rolland C. Dickson, Denise M. Harnois, Justin H. Nguyen – 24 November 2009 – Liver transplantation may occasionally be indicated in patients with unique clinical scenarios. Little is known regarding the outcomes of patients who have had a pancreatic resection prior to, in combination with, or after liver transplantation. A retrospective review of all patients undergoing liver transplantation from March 1998 to March 2008 identified 17 patients who also underwent pancreatic resection.

Evaluation of the microcirculatory disturbance of biliary ischemia after liver transplantation with contrast‐enhanced ultrasound: Preliminary experience

Jie Ren, Ming‐De Lu, Rong‐Qin Zheng, Min‐Qiang Lu, Mei Liao, Yong‐Jiang Mao, Zhi‐Juan Zheng, Yan Lu – 24 November 2009 – The aim of this study was to determine the efficacy of contrast‐enhanced ultrasound for depicting the perfusion of hilar bile ducts in ischemic‐type biliary lesions after orthotopic liver transplantation. Thirteen transplant recipients with ischemic‐type biliary lesions and 12 patients without ischemic‐type biliary lesions underwent ultrasound examinations after the injection of 1.5 mL of an intravenous contrast agent.

Predictive value of frozen‐section analysis in the histological assessment of steatosis before liver transplantation

Michelangelo Fiorentino, Francesco Vasuri, Matteo Ravaioli, Lorenza Ridolfi, Walter Franco Grigioni, Antonio Daniele Pinna, Antonia D'Errico‐Grigioni – 24 November 2009 – Histological quality assessment of donated livers is a key factor for extending the cadaveric donor pool for liver transplantation. We retrospectively compared frozen‐section analysis with routine histological permanent slides and the outcomes of grafts in liver biopsies from 294 candidate donors.

Effect of ischemic preconditioning on the genomic response to reperfusion injury in deceased donor liver transplantation

Wayel Jassem, Susan Fuggle, Richard Thompson, Matthew Arno, Jennifer Taylor, Jane Byrne, Nigel Heaton, Mohamed Rela – 24 November 2009 – Ischemic preconditioning (IP) is an effective method for protecting organs from ischemia/reperfusion (IR) injury; however, the molecular basis of this protective effect is poorly understood. This study assessed the gene expression profile in liver allografts during transplantation and evaluated the impact of IP.

Comparative prospective study of two liver graft preservation solutions: University of Wisconsin and Celsior

Rafael Lopez‐Andujar, Saulo Deusa, Eva Montalvá, Fernando San Juan, Angel Moya, Eugenia Pareja, Manuel DeJuan, Marina Berenguer, Martín Prieto, Jose Mir – 24 November 2009 – University of Wisconsin solution (UWS) is the gold standard for graft preservation. Celsior solution (CS) is a new solution not as yet widely used in liver grafts. The aim of this study was to compare the liver function of transplanted grafts stored in these 2 preservation solutions. The primary endpoints were the rates of primary nonfunction (PNF) and primary dysfunction (PDF).

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