Inhibition of hepatitis C virus replication using adeno‐associated virus vector delivery of an exogenous anti–hepatitis C virus microrna cluster

Xiao Yang, Virginia Haurigot, Shangzhen Zhou, Guangxiang Luo, Linda B Couto – 19 August 2010 – RNA interference (RNAi) is being evaluated as an alternative therapeutic strategy for hepatitis C virus (HCV) infection. The use of viral vectors encoding short hairpin RNAs (shRNAs) has been the most common strategy employed to provide sustained expression of RNAi effectors. However, overexpression and incomplete processing of shRNAs has led to saturation of the endogenous miRNA pathway, resulting in toxicity.

Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen–positive patients

Karsten Wursthorn, Mechthild Jung, Antonio Riva, Zachary D. Goodman, Patricia Lopez, Weibin Bao, Michael P. Manns, Heiner Wedemeyer, Nikolai V. Naoumov – 19 August 2010 – The impact of prolonged direct antiviral therapy on hepatitis B surface antigen (HBsAg) levels in patients with chronic hepatitis B is poorly understood.

Diagnosis of hepatocellular carcinoma in cirrhosis by dynamic contrast imaging: The importance of tumor cell differentiation

Massimo Iavarone, Angelo Sangiovanni, Laura Virginia Forzenigo, Sara Massironi, Mirella Fraquelli, Alessio Aghemo, Guido Ronchi, Piero Biondetti, Massimo Roncalli, Massimo Colombo – 19 August 2010 – Dynamic contrast imaging techniques are considered the standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in cirrhosis. However, the accuracy of radiological diagnosis depends largely on the degree of arterial hypervascularization, which increases with tumor size.

Activation of interleukin‐6–induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration

Shuk Pik Lam, John M. Luk, Kwan Man, Kevin T. P. Ng, Cindy K. Cheung, Stefan Rose‐John, Chung Mau Lo – 29 July 2010 – Adult bone marrow–derived mesenchymal stem cells (MSCs) exist in all living species and are capable of differentiating into different types of specific cells. In this study, we demonstrate the therapeutic effectiveness of rat MSC transplantation in D‐galactosamine (GalN)‐induced acute liver injury and identified the novel pathways which are involved in hepatic differentiation of MSCs.

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