New staging system and a registry for perihilar cholangiocarcinoma

Michelle L. DeOliveira, Richard D. Schulick, Yuji Nimura, Charles Rosen, Gregory Gores, Peter Neuhaus, Pierre‐Alain Clavien – 11 February 2011 – Perihilar cholangiocarcinoma is one of the most challenging diseases with poor overall survival. The major problem for anyone trying to convincingly compare studies among centers or over time is the lack of a reliable staging system. The most commonly used system is the Bismuth‐Corlette classification of bile duct involvement, which, however, does not include crucial information such as vascular encasement and distant metastases.

Ron receptor regulates Kupffer cell‐dependent cytokine production and hepatocyte survival following endotoxin exposure in mice

William D. Stuart, Rishikesh M. Kulkarni, Jerilyn K. Gray, Juozas Vasiliauskas, Mike A. Leonis, Susan E. Waltz – 11 February 2011 – Previous studies demonstrated that targeted deletion of the Ron receptor tyrosine kinase (TK) domain in mice leads to marked hepatocyte protection in a well‐characterized model of lipopolysaccharide (LPS)‐induced acute liver failure in D‐galactosamine (GalN)‐sensitized mice. Hepatocyte protection in TK−/− mice was observed despite paradoxically elevated serum levels of tumor necrosis factor alpha (TNF‐α).

Hepatic encephalopathy: A central neuroinflammatory disorder?

Roger F. Butterworth – 11 February 2011 – Encephalopathy and brain edema are serious central nervous system complications of liver failure. Recent studies using molecular probes and antibodies to cell‐specific marker proteins have demonstrated the activation of microglial cells in the brain during liver failure and confirmed a central neuroinflammatory response.

Intention‐to‐treat analysis of liver transplantation for hepatocellular carcinoma: Living versus deceased donor transplantation

Prashant Bhangui, Eric Vibert, Pietro Majno, Chady Salloum, Paola Andreani, Joao Zocrato, Philippe Ichai, Faouzi Saliba, Rene Adam, Denis Castaing, Daniel Azoulay – 11 February 2011 – For patients who have cirrhosis with hepatocellular carcinoma (HCC), living donor liver transplantation (LDLT) reduces waiting time and dropout rates. We performed a comparative intention‐to‐treat analysis of recurrence rates and survival outcomes after LDLT and deceased donor liver transplantation (DDLT) in HCC patients.

Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma

Luca Di Tommaso, Annarita Destro, Valentina Fabbris, Gaia Spagnuolo, Anna Laura Fracanzani, Silvia Fargion, Marco Maggioni, Carlo Patriarca, Roberto Maria Macchi, Michela Quagliuolo, Mauro Borzio, Massimo Iavarone, Angelo Sangiovanni, Massimo Colombo, Massimo Roncalli – 10 February 2011 – The American Association for the Study of Liver Diseases guidelines recommend the use of all available markers for improving the accuracy of the diagnosis of small hepatocellular carcinoma (HCC).

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