Endovascular closure of a hemiportocaval shunt after small‐for‐size adult‐to‐adult left lobe living donor liver transplantation

Jean F. Botha, B. Daniel Campos, Jason Johanning, David Mercer, Wendy Grant, Alan Langnas – 24 November 2009 – Adult‐to‐adult living donor liver transplantation is an accepted treatment option for patients with end‐stage liver disease. It is generally acknowledged that a graft weight to recipient body weight ratio > 0.8 is required in order to prevent the development of small‐for‐size syndrome.

Mental and physical quality of life in actual living liver donors versus potential living liver donors: A prospective, controlled, multicenter study

Karl‐Heinz Schulz, Sylvia Kroencke, Mingo Beckmann, Silvio Nadalin, Andreas Paul, Lutz Fischer, Björn Nashan, Wolfgang Senf, Yesim Erim – 24 November 2009 – In a quasi‐experimental design, we investigated the quality of life (QOL) in actual liver donors (n = 43) and potential liver donors (n = 33) before and 3 months after liver transplantation. This is the first study in this field combining a prospective design with an adequate control group.

Plasma cell hepatitis in hepatitis C virus patients post–liver transplantation: Case‐control study showing poor outcome and predictive features in the liver explant

Stephen C. Ward, Thomas D. Schiano, Swan N. Thung, M. Isabel Fiel – 24 November 2009 – Plasma cell hepatitis (PCH) is characterized by plasma cell infiltration seen in allografts of patients who underwent liver transplantation (LT) for conditions other than autoimmune hepatitis. We identified 40 PCH patients who underwent LT for hepatitis C virus (HCV) by searching our pathology database (1994–2006) for the keywords liver allograft, lymphoplasmacytic, and plasma cell(s). We selected 2 control patients who received LT for HCV for each PCH case.

Ethical perspectives on living donor organ transplantation in Asia

Allan M. Concejero, Chao‐Long Chen – 24 November 2009 – Live donors are a continuing source of organ grafts for solid organ transplantation in Asia. Ethical issues surrounding the development of living donor organ transplantation in Eastern countries are different from those in Western countries. Donor safety is still the paramount concern in any donor operation. Issues on organ trafficking remain societal concerns in low‐income nations. Religion, cultural background, economic prerogatives, and timely legislation contribute to the social acceptance and maturation of organ donation.

Impact of sirolimus on the recurrence of hepatocellular carcinoma after liver transplantation

Srinath Chinnakotla, Gary L. Davis, Sugam Vasani, Peter Kim, Koji Tomiyama, Edmund Sanchez, Nicholas Onaca, Robert Goldstein, Marlon Levy, Göran B. Klintmalm – 24 November 2009 – Tumor recurrence after liver transplantation for hepatocellular carcinoma is associated with a poor prognosis. Because immunosuppression is a well‐known risk factor for tumor growth, it is surprising that its possible role in the outcome of liver transplantation has been poorly evaluated.

Living donor liver transplantation for glycogen storage disease type Ib

Mureo Kasahara, Reiko Horikawa, Seisuke Sakamoto, Takanobu Shigeta, Hideaki Tanaka, Akinari Fukuda, Kiyomi Abe, Keisuke Yoshii, Yasuhiro Naiki, Rika Kosaki, Atsuko Nakagawa – 24 November 2009 – Glycogen storage disease type 1b (GSD‐1b) is due to an autosomal recessive inborn error of carbohydrate metabolism caused by defects in glucose‐6‐phosphatase translocase. Patients with GSD‐1b have severe hypoglycemia with several clinical manifestations of hepatomegaly, obesity, a doll‐like face, and neutropenia. Liver transplantation has been indicated for severe glucose intolerance.

Prospective validation of a noninvasive index for predicting liver fibrosis in hepatitis C virus–infected liver transplant recipients

Salvador Benlloch, Laura Heredia, Claudia Barquero, José‐Miguel Rayón, Ramón Pina, Victoria Aguilera, Martín Prieto, Marina Berenguer – 24 November 2009 – We previously developed a mathematical model, the Hospital Universitario La Fe (HULF) index, as an alternative to protocol liver biopsy (PLB) to estimate significant fibrosis (SF) in patients who underwent liver transplantation (LT) for liver damage caused by chronic HCV infection. In the present study, we sought to validate this noninvasive index.

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