Posttransplant metabolic syndrome: An epidemic waiting to happen

Mangesh Pagadala, Srinivasan Dasarathy, Bijan Eghtesad, Arthur J. McCullough – 24 November 2009 – With increasing survival after orthotopic liver transplantation (OLT), metabolic syndrome and its individual components, including diabetes mellitus, hypertension, dyslipidemia, and obesity, are increasingly being identified and contributing to cardiovascular complications and late morbidity and mortality. The prevalence of posttransplant metabolic syndrome (PTMS) and its individual components has been found to be higher post‐OLT versus a comparable population without OLT.

Clinical utility of an automated pupillometer for assessing and monitoring recipients of liver transplantation

Sheng Yan, Zhenhua Tu, Weifeng Lu, Qiyi Zhang, Jiangjuan He, Zhiwei Li, Yi Shao, Weilin Wang, Min Zhang, Shusen Zheng – 24 November 2009 – Pupil examination has been used as a basic measure in critically ill patients and has great importance for the prognosis and management of disease. An automated pupillometer is a computer‐based infrared digital video system by which the accuracy and precision of the pupil examination are markedly improved.

Improvement of renal function after the switch from a calcineurin inhibitor to everolimus in liver transplant recipients with chronic renal dysfunction

Javier F. Castroagudín, Esther Molina, Rafael Romero, Esteban Otero, Santiago Tomé, Evaristo Varo – 24 November 2009 – Chronic renal dysfunction is a frequent and severe complication in solid‐organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and sirolimus), can improve renal function in these patients, but available data about the efficacy and safety of everolimus in liver transplant recipients are scarce.

Differential transcriptome patterns for acute cellular rejection in recipients with recurrent hepatitis C after liver transplantation

Tadafumi Asaoka, Tomoaki Kato, Shigeru Marubashi, Keizo Dono, Naoki Hama, Hidenori Takahashi, Shogo Kobayashi, Yutaka Takeda, Ichiro Takemasa, Hiroaki Nagano, Hideo Yoshida, Phillip Ruiz, Andreas G. Tzakis, Kenichi Matsubara, Morito Monden, Yuichiro Doki, Masaki Mori – 24 November 2009 – Histopathological evaluation of the liver via biopsy remains the standard procedure for the diagnosis of both acute cellular rejection (ACR) and recurrent hepatitis C (RHC) after liver transplantation.

Increased risk of graft loss from hepatic artery thrombosis after liver transplantation with older donors

Zoe A. Stewart, Jayme E. Locke, Dorry L. Segev, Nabil N. Dagher, Andrew L. Singer, Robert A. Montgomery, Andrew M. Cameron – 24 November 2009 – Hepatic artery thrombosis (HAT) is the most common vascular complication after liver transplantation; it has been reported to occur in 2% to 5% of liver transplant recipients. Most reports of HAT in the literature describe single‐center series with small numbers of patients and lack the power to definitively identify nontechnical risk factors.

Liver transplantation and pancreatic resection: A single‐center experience and a review of the literature

John A. Stauffer, Jeffery L. Steers, Hugo Bonatti, Marjorie K. Dougherty, Jaime Aranda‐Michel, Rolland C. Dickson, Denise M. Harnois, Justin H. Nguyen – 24 November 2009 – Liver transplantation may occasionally be indicated in patients with unique clinical scenarios. Little is known regarding the outcomes of patients who have had a pancreatic resection prior to, in combination with, or after liver transplantation. A retrospective review of all patients undergoing liver transplantation from March 1998 to March 2008 identified 17 patients who also underwent pancreatic resection.

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