Kupffer cell and interleukin‐12–dependent loss of natural killer T cells in hepatosteatosis

Michael Kremer, Emmanuel Thomas, Richard J. Milton, Ashley W. Perry, Nico van Rooijen, Michael D. Wheeler, Steven Zacks, Michael Fried, Richard A. Rippe, Ian N. Hines – 23 December 2009 – Hepatosteatosis is associated with increased expression of tumor necrosis factor alpha (TNF‐α) and interleukin (IL)‐12, major T helper (Th) 1 cytokines, and reduced hepatic natural killer T (NKT) cell numbers. The relationship between lipid accumulation, cytokine expression, and hepatic NKT cells is not known.

Interleukin‐17–producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

Ji‐Yuan Zhang, Zheng Zhang, Fang Lin, Zheng‐Sheng Zou, Ruo‐Nan Xu, Lei Jin, Jun‐Liang Fu, Feng Shi, Ming Shi, Hui‐Fen Wang, Fu‐Sheng Wang – 23 December 2009 – Interleukin‐17 (IL‐17)‐producing CD4+ T cells (Th17)‐mediated immune response has been demonstrated to play a critical role in inflammation‐associated disease; however, its role in chronic hepatitis B virus (HBV) infection remains unknown.

Long‐term efficacy of tenofovir monotherapy for hepatitis B virus‐monoinfected patients after failure of nucleoside/nucleotide analogues

Florian van Bömmel, Robert A. de Man, Heiner Wedemeyer, Katja Deterding, Jörg Petersen, Peter Buggisch, Andreas Erhardt, Dietrich Hüppe, Kerstin Stein, Jörg Trojan, Christoph Sarrazin, Wulf O. Böcher, Ulrich Spengler, Hermann E. Wasmuth, Jurrien G.P.

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