Marina Núñez – 26 August 2010 – Highly active antiretroviral therapy (HAART)‐related hepatotoxicity complicates the management of patients infected with human immunodeficiency virus (HIV), increases medical costs, alters the prescription patterns, and affects the guideline recommendations.
Alexander Dechêne, Jan‐Peter Sowa, Robert K. Gieseler, Christoph Jochum, Lars P. Bechmann, Amr El Fouly, Martin Schlattjan, Fuat Saner, Hideo A. Baba, Andreas Paul, Volker Dries, Margarethe Odenthal, Guido Gerken, Scott L. Friedman, Ali Canbay – 26 August 2010 – Acute liver failure (ALF) is associated with massive short‐term cell death, whereas chronic liver injury is accompanied by continuous cell death. Hepatic stellate cells (HSCs) contribute to tissue repair and liver fibrosis in chronic liver injury, although their role in ALF remains unexplained.
Raymund R. Razonable – 26 August 2010
Bijan Raziorrouh, Winfried Schraut, Tilman Gerlach, Daniela Nowack, Norbert H. Grüner, Axel Ulsenheimer, Reinhart Zachoval, Martin Wächtler, Michael Spannagl, Jürgen Haas, Helmut M. Diepolder, Maria‐Christina Jung – 25 August 2010 – Multiple inhibitory receptors may play a role in the weak or absent CD8+ T‐cell response in chronic hepatitis B virus (HBV) infection. Yet few receptors have been characterized in detail and little is known about their complex regulation.
Julien Villeneuve, Sébastien Lepreux, Audrey Mulot, Annie M. Bérard, Arisa Higa‐Nishiyama, Pierre Costet, Victor De Ledinghen, Paulette Bioulac‐Sage, Charles Balabaud, Alan T. Nurden, Jean Rosenbaum, Eric Chevet, Jean Ripoche – 25 August 2010 – Inflammation and lipid metabolism pathways are linked, and deregulation of this interface may be critical in hepatic steatosis. The importance of the dialog between inflammatory signaling pathways and the unfolded protein response (UPR) in metabolism has been underlined.
Maureen M. Jonas, Joan M. Block, Barbara A. Haber, Saul J. Karpen, W. Thomas London, Karen F. Murray, Michael R. Narkewicz, Philip Rosenthal, Kathleen B. Schwarz, Brian J. McMahon – 25 August 2010 – Chronic hepatitis B virus (HBV) infection in children presents a therapeutic challenge for the practitioner. Decisions regarding selection of patients who may benefit from treatment, appropriate timing of treatment, and the choice of antiviral therapy are complex and are compounded by the limited number of drugs that have been studied in children.
23 August 2010
Gerald U. Denk, Silvia Maitz, Ralf Wimmer, Christian Rust, Pietro Invernizzi, Sacha Ferdinandusse, Wim Kulik, Andrea Fuchsbichler, Peter Fickert, Michael Trauner, Alan F. Hofmann, Ulrich Beuers – 20 August 2010 – NorUDCA (24‐norursodeoxycholic acid), the C23‐homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP‐binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis.
Lieve Braeye, Ruben Vanheste – 20 August 2010
Marcos Martínez‐Clemente, Natàlia Ferré, Esther Titos, Raquel Horrillo, Ana González‐Périz, Eva Morán‐Salvador, Cristina López‐Vicario, Rosa Miquel, Vicente Arroyo, Colin D. Funk, Joan Clària – 20 August 2010 – We have shown that Alox15, the gene encoding for 12/15‐lipoxygenase (12/15‐LO), is markedly up‐regulated in livers from apolipoprotein E‐deficient (ApoE−/−) mice, which spontaneously develop nonalcoholic fatty liver disease secondary to hyperlipidemia.