Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

Craig Lammert, Einar Bjornsson, Anna Niklasson, Naga Chalasani – 25 January 2010 – Reactive metabolites generated by hepatic metabolism are thought to play an important role in the pathogenesis of drug‐induced liver injury (DILI), but supporting data are limited. If this is true, then compounds with significant hepatic metabolism should cause more DILI than those without it. We conducted a study to examine the relationship between hepatic metabolism and DILI of prescription medications.

The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response

Elisabeth Lehmann, Walid Hamdy El‐Tantawy, Matthias Ocker, Ralf Bartenschlager, Volker Lohmann, Said Hashemolhosseini, Gisa Tiegs, Gabriele Sass – 25 January 2010 – The anti‐inflammatory and antiapoptotic heme degrading enzyme heme oxygenase‐1 (HO‐1) has been shown recently to interfere with replication of hepatitis C virus (HCV). We investigated the effect of HO‐1 products carbon monoxide (CO), iron and biliverdin on HCV replication using the replicon cell lines Huh‐5‐15 and LucUbiNeo‐ET, stably expressing HCV proteins NS3 through NS5B.

Cost‐effectiveness of nationwide hepatitis B catch‐up vaccination among children and adolescents in China

David W. Hutton, Samuel K. So, Margaret L. Brandeau – 25 January 2010 – Liver disease and liver cancer associated with childhood‐acquired chronic hepatitis B are leading causes of death among adults in China. Despite expanded newborn hepatitis B vaccination programs, approximately 20% of children under age 5 years and 40% of children aged 5 to 19 years remain unprotected from hepatitis B. Although immunizing them will be beneficial, no studies have examined the cost‐effectiveness of hepatitis B catch‐up vaccination in an endemic country like China.

Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF‐κB signaling pathway

Yu‐Xiong Feng, Jiang‐Sha Zhao, Jing‐Jing Li, Tao Wang, Shu‐Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao‐Fan Wang, Dong Xie – 25 January 2010 – Eph/Ephrin family, one of the largest receptor tyrosine kinase families, has been extensively studied in morphogenesis and neural development. Recently, growing attention has been paid to its role in the initiation and progression of various cancers. However, the role of Eph/Ephrins in hepatocellular carcinoma (HCC) has been rarely investigated.

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