Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course

Juan F. Gallegos‐Orozco, Amir Yosephy, Brie Noble, Bashar A. Aqel, Thomas J. Byrne, Elizabeth J. Carey, David D. Douglas, David Mulligan, Adyr Moss, Giovanni de Petris, James W. Williams, Jorge Rakela, Hugo E. Vargas – 24 November 2009 – Our aim was to assess long‐term survival in patients transplanted for HCV‐related end‐stage liver disease (ESLD) and evaluate potentially modifiable predictors of survival. We performed a retrospective analysis of adult liver transplants (LT) at our institution for HCV‐related ESLD since the program's inception.

Living donor liver transplantation for hepatocellular carcinoma: Increased recurrence but improved survival

Khashayar Vakili, James J. Pomposelli, Yee Lee Cheah, Mohamed Akoad, W. David Lewis, Urmila Khettry, Fredric Gordon, Khalid Khwaja, Roger Jenkins, Elizabeth A. Pomfret – 24 November 2009 – In regions with a limited deceased donor pool, living donor adult liver transplantation (LDALT) has become an important treatment modality for patients with hepatocellular carcinoma (HCC) and cirrhosis. Studies have shown higher recurrence rates of HCC after LDALT in comparison with deceased donor liver transplantation (DDLT).

Acute kidney injury during liver transplantation as determined by neutrophil gelatinase‐associated lipocalin

Claus U. Niemann, Ann Walia, Jeffrey Waldman, Michael Davio, John P. Roberts, Ryutaro Hirose, John Feiner – 24 November 2009 – Acute kidney injury (AKI) has significant prognostic implications for long‐term outcomes in patients undergoing liver transplantation. In several retrospective studies, perioperative variables have been associated with AKI. These variables have been mainly associated with changes in creatinine concentrations over several days or months post‐transplantation.

Long‐term outcomes of emergency liver transplantation for acute liver failure

Gabriel Chan, Ali Taqi, Paul Marotta, Mark Levstik, Vivian McAlister, William Wall, Douglas Quan – 24 November 2009 – Acute liver failure continues to be associated with a high mortality rate, and emergency liver transplantation is often the only life‐saving treatment. The short‐term outcomes are decidedly worse in comparison with those for nonurgent cases, whereas the long‐term results have not been reported as extensively. We report our center's experience with urgent liver transplantation, long‐term survival, and major complications.

Posttransplant metabolic syndrome: An epidemic waiting to happen

Mangesh Pagadala, Srinivasan Dasarathy, Bijan Eghtesad, Arthur J. McCullough – 24 November 2009 – With increasing survival after orthotopic liver transplantation (OLT), metabolic syndrome and its individual components, including diabetes mellitus, hypertension, dyslipidemia, and obesity, are increasingly being identified and contributing to cardiovascular complications and late morbidity and mortality. The prevalence of posttransplant metabolic syndrome (PTMS) and its individual components has been found to be higher post‐OLT versus a comparable population without OLT.

Clinical utility of an automated pupillometer for assessing and monitoring recipients of liver transplantation

Sheng Yan, Zhenhua Tu, Weifeng Lu, Qiyi Zhang, Jiangjuan He, Zhiwei Li, Yi Shao, Weilin Wang, Min Zhang, Shusen Zheng – 24 November 2009 – Pupil examination has been used as a basic measure in critically ill patients and has great importance for the prognosis and management of disease. An automated pupillometer is a computer‐based infrared digital video system by which the accuracy and precision of the pupil examination are markedly improved.

Improvement of renal function after the switch from a calcineurin inhibitor to everolimus in liver transplant recipients with chronic renal dysfunction

Javier F. Castroagudín, Esther Molina, Rafael Romero, Esteban Otero, Santiago Tomé, Evaristo Varo – 24 November 2009 – Chronic renal dysfunction is a frequent and severe complication in solid‐organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and sirolimus), can improve renal function in these patients, but available data about the efficacy and safety of everolimus in liver transplant recipients are scarce.

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