Interleukin‐17–producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

Ji‐Yuan Zhang, Zheng Zhang, Fang Lin, Zheng‐Sheng Zou, Ruo‐Nan Xu, Lei Jin, Jun‐Liang Fu, Feng Shi, Ming Shi, Hui‐Fen Wang, Fu‐Sheng Wang – 23 December 2009 – Interleukin‐17 (IL‐17)‐producing CD4+ T cells (Th17)‐mediated immune response has been demonstrated to play a critical role in inflammation‐associated disease; however, its role in chronic hepatitis B virus (HBV) infection remains unknown.

Long‐term efficacy of tenofovir monotherapy for hepatitis B virus‐monoinfected patients after failure of nucleoside/nucleotide analogues

Florian van Bömmel, Robert A. de Man, Heiner Wedemeyer, Katja Deterding, Jörg Petersen, Peter Buggisch, Andreas Erhardt, Dietrich Hüppe, Kerstin Stein, Jörg Trojan, Christoph Sarrazin, Wulf O. Böcher, Ulrich Spengler, Hermann E. Wasmuth, Jurrien G.P.

Alcoholic liver disease

Robert S. O'Shea, Srinivasan Dasarathy, Arthur J. McCullough, Practice Guideline Committee of the American Association for the Study of Liver Diseases and the Practice Parameters Committee of the American College of Gastroenterology – 23 December 2009

Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease

Lauren N. Bell, Janice L. Theodorakis, Raj Vuppalanchi, Romil Saxena, Kerry G. Bemis, Mu Wang, Naga Chalasani – 23 December 2009 – Nonalcoholic fatty liver disease (NAFLD), ranging from relatively benign simple steatosis to progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common chronic liver disease. Liver biopsy is currently the only reliable tool for staging the subtypes of NAFLD; therefore, noninvasive serum biomarkers for evaluation of liver disease and fibrosis are urgently needed.

Long‐term outcomes of positive fluorescence in situ hybridization tests in primary sclerosing cholangitis

Sanjay Y. Bangarulingam, Einar Bjornsson, Felicity Enders, Emily G. Barr Fritcher, Gregory Gores, Kevin C. Halling, Keith D. Lindor – 23 December 2009 – Patients with primary sclerosing cholangitis (PSC) are at increased risk for developing cholangiocarcinoma (CCA). Fluorescence in situ hybridization (FISH) is a cytological test designed to enhance early CCA diagnosis. The long‐term outcome of PSC patients with a positive FISH test (polysomy, trisomy/tetrasomy) are unclear.

Gender‐specific differences associated with living donor liver transplantation: A review study

Hanna C. Hermann, Burghard F. Klapp, Gerhard Danzer, Christina Papachristou – 16 December 2009 – Living donor liver transplantation (LDLT) has developed into an important therapeutic option for liver diseases. For living donor kidney transplantation (LDKT), gender‐specific differences have been observed among both donors (two‐thirds being women and one‐third being men) and recipients (two‐thirds being men and one‐third being women). The aim of this study was to determine whether there is a gender disparity for LDLT.

Rapamycin and tacrolimus differentially modulate acute graft‐versus‐host disease in rats after liver transplantation

Guodong Xu, Linyan Wang, Wei Chen, Fei Xue, Xueli Bai, Liang Liang, Xuning Shen, Mangli Zhang, Dajing Xia, Tingbo Liang – 16 December 2009 – Acute graft‐versus‐host disease (aGVHD) is a serious complication of liver transplantation (LTx); it occurs in 1% to 2% of liver allograft recipients. The condition has a poor prognosis and poses major diagnostic and therapeutic challenges. A rat model of aGVHD after LTx has been developed, and a relative decrease in regulatory T (Treg) cells has been shown to be associated with this model.

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