Underestimation of hepatitis C virus genotype 4 RNA levels by the Cobas AmpliPrep/Cobas TaqMan assay
Stéphane Chevaliez, Jenna Fix, Alexandre Soulier, Jean‐Michel Pawlotsky – 29 October 2009
Radiofrequency ablation of hepatocellular carcinoma: Long‐term results and prognostic factors in 235 Western patients with cirrhosis
Gisèle N'Kontchou, Amel Mahamoudi, Mounir Aout, Nathalie Ganne‐Carrié, Véronique Grando, Emmanuelle Coderc, Eric Vicaut, Jean Claude Trinchet, Nicolas Sellier, Michel Beaugrand, Olivier Seror – 29 October 2009 – For the treatment of small hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) is in some centers considered a first‐line therapeutic option. However, such a strategy is still under debate with regard to tumor and patient characteristics.
Nuclear factor erythroid 2–related factor 2 is a positive regulator of human bile salt export pump expression
Jittima Weerachayaphorn, Shi‐Ying Cai, Carol J. Soroka, James L. Boyer – 29 October 2009 – The bile salt export pump (BSEP) is the major determinant of bile salt–dependent bile secretion, and its deficiency leads to cholestatic liver injury. BSEP/Bsep gene expression is regulated by the nuclear farnesoid X receptor. However, BSEP expression, though reduced, is retained in the livers of Fxr−/− mice, indicating that additional transcriptional factors may regulate its expression.
Immature myeloid cells induced by a high‐fat diet contribute to liver inflammation
Zhong‐bin Deng, Yuelong Liu, Cunren Liu, Xiaoyu Xiang, Jianhua Wang, Ziqiang Cheng, Spandan V. Shah, Shuangyin Zhang, Liming Zhang, Xiaoying Zhuang, Sue Michalek, William E. Grizzle, Huang‐Ge Zhang – 29 October 2009 – Chronic inflammation plays a critical role in promoting obesity‐related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation.
Sexual dysfunction after liver transplantation
Patrizia Burra – 29 October 2009 – Key Points
Late surgical complications following liver transplantation
Paige M. Porrett, John Hsu, Abraham Shaked – 29 October 2009 – Key Points
What is the real gain after liver transplantation?
James Neuberger – 29 October 2009 – Key Points
Comment on the PROVE1 and PROVE2 clinical trials: “I was taking a picture of rapid virological response with telaprevir, but the background is unfocused!”
Leonardo Baiocchi, Ilaria Lenci, Marco Carbone, Mario Angelico – 29 October 2009
Reply:
Neal D. Freedman, Teresa M. Curto, James E. Everhart – 29 October 2009
Farnesyltransferase inhibitors reduce ras activation and ameliorate acetaminophen‐induced liver injury in mice
Banishree Saha, Dipankar Nandi – 29 October 2009 – Hepatotoxicity due to overdose of the analgesic and antipyretic acetaminophen (APAP) is a major cause of liver failure in adults. To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400–500 mg/kg). Ras–guanosine triphosphate (GTP) is induced early and in an oxidative stress‐dependent manner.