Recurrent low gamma‐glutamyl Transpeptidase cholestasis following liver transplantation for bile salt export pump (BSEP) disease (posttransplant recurrent BSEP disease)

Leah Siebold, Andre A. S. Dick, Richard Thompson, Giuseppe Maggiore, Emanuel Jacquemin, Ronald Jaffe, Sandra Strautnieks, Tassos Grammatikopoulos, Simon Horslen, Peter F. Whitington, Benjamin L. Shneider – 25 June 2010 – Bile salt export pump (BSEP) deficiency is a hereditary cholestatic syndrome that results from mutations in the ABCB11 (ATP‐binding cassette B11) gene. Severely affected patients develop end‐stage liver disease in the first decade of life. Liver transplantation has traditionally been thought of as curative for BSEP disease.

Long‐term results of urgent revascularization for hepatic artery thrombosis after pediatric liver transplantation

Nienke Warnaar, Wojciech G. Polak, Koert P. de Jong, Marieke T. de Boer, Henkjan J. Verkade, Egbert Sieders, Paul M. J. G. Peeters, Robert J. Porte – 25 June 2010 – Hepatic artery thrombosis (HAT) after pediatric orthotopic liver transplantation (OLT) is a serious complication resulting in bile duct necrosis and often requiring retransplantation. Immediate surgical thrombectomy/thrombolysis has been reported to be a potentially successful treatment for restoring blood flow and avoiding urgent retransplantation. The long‐term results of this strategy remain to be determined.

Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation

Viviana Moroso, Herold J. Metselaar, Shanta Mancham, Hugo W. Tilanus, Diana Eissens, Arnold van der Meer, Luc J. W. van der Laan, Ernst J. Kuipers, Irma Joosten, Jaap Kwekkeboom – 25 June 2010 – In contrast to other solid organ transplantations, liver grafts have tolerogenic properties. Animal models indicate that donor leukocytes transferred into the recipient after liver transplantation (LTX) play a relevant role in this tolerogenic phenomenon. However, the specific donor cell types involved in modulation of the recipient alloresponse are not yet defined.

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