Human liver stem cells originate from the canals of hering
Nimantha De Alwis, Gavin Hudson, Alastair D. Burt, Christopher P. Day, Patrick F. Chinnery – 27 August 2009
Degree of cross‐genotype reactivity of hepatitis C virus–specific CD8+ T cells directed against NS3
Silvia Giugliano, Filiz Oezkan, Mathias Bedrejowski, Markus Kudla, Markus Reiser, Sergei Viazov, Norbert Scherbaum, Michael Roggendorf, Joerg Timm – 27 August 2009 – The inherent sequence diversity of the hepatitis C virus (HCV) with the existence of multiple genotypes that differ up to 20% at the amino acid level represents one of the major obstacles for immune control.
Adipokines in liver diseases
Fabio Marra, Cristiana Bertolani – 27 August 2009 – Adipokines are polypeptides secreted in the adipose tissue in a regulated manner. While some of these molecules are expressed only by adipocytes, resident and infiltrating macrophages and components of the vascular stroma markedly contribute to expression of other adipokines. As a result, adipose tissue inflammation is associated with a modification in the pattern of adipokine secretion.
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis
Heike Bantel, Matthias J. Bahr, Klaus Schulze‐Osthoff – 27 August 2009
Chronic hepatitis B: Update 2009
Anna S. F. Lok, Brian J. McMahon – 27 August 2009
Reply:
Bruce R. Bacon – 27 August 2009
Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed
Dhiraj Tripathi, James W. Ferguson, Narendra Kochar, Joanna A. Leithead, George Therapondos, Norma C. Mcavoy, Adrian J. Stanley, Ewan H. Forrest, William S. Hislop, Peter R. Mills, Peter C. Hayes – 27 August 2009 – Current therapy for preventing the first variceal bleed includes beta‐blocker and variceal band ligation (VBL). VBL has lower bleeding rates, with no differences in survival, whereas beta‐blocker therapy can be limited by side effects.
Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C
Ester Vanni, Maria Lorena Abate, Elena Gentilcore, Ingrid Hickman, Roberto Gambino, Maurizio Cassader, Antonina Smedile, Ele Ferrannini, Mario Rizzetto, Giulio Marchesini, Amalia Gastaldelli, Elisabetta Bugianesi – 27 August 2009 – Chronic hepatitis C (CHC) has been associated with type 2 diabetes and insulin resistance, but the extent of impairment in insulin action, the target pathways involved, and the role of the virus per se have not been defined.
Porcine liver sinusoidal endothelial cells contribute significantly to intrahepatic ammonia metabolism
Geir I. Nedredal, Kjetil Elvevold, Lars M. Ytrebø, Ole‐Martin Fuskevåg, Ingvild Pettersen, Peter A. G. McCourt, Kjell Bertheussen, Bård Smedsrød, Arthur Revhaug – 27 August 2009 – Ammonia metabolism in the liver has been largely credited to hepatocytes (HCs). We have shown that liver nonparenchymal cells that include liver sinusoidal endothelial cells (LSECs) produce ammonia.
A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment‐naïve patients with chronic hepatitis C: ViSER1 results
Yves Benhamou, Nezam H. Afdhal, David R. Nelson, Mitchell L. Shiffman, Deanine G. Halliman, Jamie Heise, Eric Chun, Paul J. Pockros – 27 August 2009 – Pegylated interferon (peg‐IFN) and ribavirin (RBV) are effective in eradicating the hepatitis C virus in more than half of patients. However, anemia arising from RBV‐induced hemolysis can prompt dose reductions and lower sustained virologic response (SVR) rates.