High‐dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis

Keith D. Lindor, Kris V. Kowdley, Velimir A. C. Luketic, M. Edwyn Harrison, Timothy McCashland, Alex S. Befeler, Denise Harnois, Roberta Jorgensen, Jan Petz, Jill Keach, Jody Mooney, Carol Sargeant, Julie Braaten, Tamara Bernard, Debra King, Ellen Miceli, Jeff Schmoll, Tanya Hoskin, Prabin Thapa, Felicity Enders – 27 August 2009 – Previous controlled trials are inconclusive regarding the efficacy of ursodeoxycholic acid (UDCA) for treating primary sclerosing cholangitis (PSC).

Degree of cross‐genotype reactivity of hepatitis C virus–specific CD8+ T cells directed against NS3

Silvia Giugliano, Filiz Oezkan, Mathias Bedrejowski, Markus Kudla, Markus Reiser, Sergei Viazov, Norbert Scherbaum, Michael Roggendorf, Joerg Timm – 27 August 2009 – The inherent sequence diversity of the hepatitis C virus (HCV) with the existence of multiple genotypes that differ up to 20% at the amino acid level represents one of the major obstacles for immune control.

Adipokines in liver diseases

Fabio Marra, Cristiana Bertolani – 27 August 2009 – Adipokines are polypeptides secreted in the adipose tissue in a regulated manner. While some of these molecules are expressed only by adipocytes, resident and infiltrating macrophages and components of the vascular stroma markedly contribute to expression of other adipokines. As a result, adipose tissue inflammation is associated with a modification in the pattern of adipokine secretion.

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