Alternative pathway therapy for hyperammonemia in liver failure
Fin Stolze Larsen, Julia Wendon – 23 June 2009
Chromodomain helicase/adenosine triphosphatase DNA binding protein 1–like (CHD1l) gene suppresses the nucleus‐to‐mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival
Leilei Chen, Liang Hu, Tim Hon Man Chan, George Sai‐Wah Tsao, Dan Xie, Ke‐Ke Huo, Li Fu, Stephanie Ma, Bo‐Jian Zheng, Xin‐Yuan Guan – 23 June 2009 – Amplification of 1q21 has been detected in 58% to 78% of primary hepatocellular carcinoma cases, suggesting that one or more oncogenes within the amplicon play a critical role in the development of this disease. The chromodomain helicase/adenosine triphosphatase DNA binding protein 1–like gene (CHD1L) is a recently identified oncogene localized at 1q21.
L‐ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure
Lars Marius Ytrebø, Rune Gangsøy Kristiansen, Hanne Mæhre, Ole Martin Fuskevåg, Trine Kalstad, Arthur Revhaug, María Jover Cobos, Rajiv Jalan, Christopher F. Rose – 23 June 2009 – Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation.
Utility of magnetic resonance imaging in the evaluation of hepatic fat content
Melania Manco, Valerio Nobili – 23 June 2009
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Kinji Asahina, Hidekazu Tsukamoto – 23 June 2009
Management of patients with hepatitis C virus genotype 2 or 3: Comments on updated american association for the study of liver diseases practice guidelines
Olav Dalgard, Alessandra Mangia – 23 June 2009
Bile salt–phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent
Walee Chamulitrat, Jürgen Burhenne, Tobias Rehlen, Anita Pathil, Wolfgang Stremmel – 23 June 2009 – A decrease of hepatocellular phosphatidylcholine (PC) is associated with hepatic injury, e.g., in nonalcoholic steatohepatitis (NASH). Therefore, we evaluated the hepatoprotective effect of a PC‐precursor lipid specifically targeted to the liver. We synthesized the bile acid‐phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA‐LPE), which was designed to target PC to hepatocytes by way of bile‐acid transport systems.
Orlistat for overweight subjects with nonalcoholic steatohepatitis
Joanna K. Dowman, Deborah Stocken, Jeremy W. Tomlinson, Philip Newsome – 23 June 2009
Apolipoprotein B100 acts as a molecular link between lipid‐induced endoplasmic reticulum stress and hepatic insulin resistance
Qiaozhu Su, Julie Tsai, Elaine Xu, Wei Qiu, Erika Bereczki, Miklos Santha, Khosrow Adeli – 23 June 2009 – Accumulation of unfolded and misfolded proteins in the endoplasmic reticulum (ER) results in ER stress and lipid overload‐induced ER stress has been implicated in the development of insulin resistance. Here, evidence is provided for a molecular link between hepatic apolipoprotein B100 (apoB100), induction of ER stress, and attenuated insulin signaling.