Jian Zhao, Guobin Wu, Fangfang Bu, Bin Lu, Anmin Liang, Lei Cao, Xin Tong, Xin Lu, Mengchao Wu, Yajun Guo – 23 December 2009 – The ankyrin‐repeat–containing, SH3‐domain–containing, and proline‐rich‐region–containing protein (ASPP) family of proteins regulates apoptosis through interaction with p53 and its family members. This study evaluated the epigenetic regulation of ASPP1 and ASPP2 in hepatitis B virus (HBV)‐positive hepatocellular carcinoma (HCC) and explores the effects of down‐regulation of ASPP1 and ASPP2 on the development of HCC.

Alessandro Vitale, Michael L. Volk, Davide Pastorelli, Sara Lonardi, Fabio Farinati, Patrizia Burra, Paolo Angeli, Umberto Cillo – 23 December 2009 – The role of bridging therapies for patients with hepatocellular carcinoma (HCC) on the waiting list for liver transplantation (LT) remains controversial. There is strong evidence to support the effectiveness of sorafenib in extending the time to progression of HCC.

Yosuke Osawa, Ekihiro Seki, Masayuki Adachi, Atsushi Suetsugu, Hiroyasu Ito, Hisataka Moriwaki, Mitsuru Seishima, Masahito Nagaki – 23 December 2009 – Kupffer cells, resident tissue macrophages of the liver, play a key role in the regulation of hepatic inflammation, hepatocyte death, and fibrosis that characterize liver diseases. However, it is controversial whether Kupffer cells promote or protect from liver injury.

Gareth J. Sullivan, David C. Hay, In‐Hyun Park, Judy Fletcher, Zara Hannoun, Catherine M. Payne, Donna Dalgetty, James R. Black, James A. Ross, Kay Samuel, Gang Wang, George Q. Daley, Je‐Hyuk Lee, George M. Church, Stuart J. Forbes, John P. Iredale, Ian Wilmut – 23 December 2009 – With the advent of induced pluripotent stem cell (iPSC) technology, it is now feasible to generate iPSCs with a defined genotype or disease state.

Ian N. Hines – 23 December 2009

Hisashi Moriguchi, Raymond T. Chung, Chifumi Sato – 23 December 2009

Rosa Quiles‐Perez, José Antonio Muñoz‐Gámez, Ángeles Ruiz‐Extremera, Francisco O'Valle, Laura Sanjuán‐Nuñez, Ana Belén Martín‐Álvarez, David Martín‐Oliva, Trinidad Caballero, Paloma Muñoz de Rueda, Josefa León, Raúl Gonzalez, Jordi Muntané, Francisco Javier Oliver, Javier Salmerón – 23 December 2009 – Hepatocellular carcinoma (HCC) is associated with a poor prognosis due to a lack of effective treatment options. In HCC a significant role is played by DNA damage and the inflammatory response.

Loredana Fiorentino, Alessia Vivanti, Michele Cavalera, Valeria Marzano, Maurizio Ronci, Marta Fabrizi, Stefano Menini, Giuseppe Pugliese, Rossella Menghini, Rama Khokha, Renato Lauro, Andrea Urbani, Massimo Federici – 23 December 2009 – Tumor necrosis factor α–converting enzyme (TACE, also known as ADAM17) was recently involved in the pathogenesis of insulin resistance.

Wagane J. A. Benga, Sophie E. Krieger, Maria Dimitrova, Mirjam B. Zeisel, Marie Parnot, Joachim Lupberger, Eberhard Hildt, Guangxiang Luo, John McLauchlan, Thomas F. Baumert, Catherine Schuster – 23 December 2009 – Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Restriction of HCV infection to human hepatocytes suggests that liver‐specific host factors play a role in the viral life cycle.

Apurva A. Modi, Jordan J. Feld, Yoon Park, David E. Kleiner, James E. Everhart, T. Jake Liang, Jay H. Hoofnagle – 23 December 2009 – Although coffee consumption has been associated with reduced frequency of liver disease, it is unclear whether the effect is from coffee or caffeine and whether there is an effect on hepatic fibrosis specifically. This study was undertaken to use a food‐frequency instrument for dietary caffeine consumption to evaluate the relationship between caffeine intake and liver fibrosis.