Maria Serena Longhi, Ragai R. Mitry, Marianne Samyn, Astrid Scalori, Munther J. Hussain, Alberto Quaglia, Giorgina Mieli‐Vergani, Yun Ma, Diego Vergani – 23 June 2009 – Interface hepatitis, the histological lesion typical of autoimmune hepatitis (AIH), is composed of CD4 and CD8 T lymphocytes and of innate immunity cells, particularly monocytes. Studies in AIH have focused on autoreactive CD4 and CD8 T cells and impairment of CD4+CD25+ regulatory T cells (T‐regs), whereas little is known about the role of monocytes and their relationship with T‐regs.

Leen Delang, Jan Paeshuyse, Inge Vliegen, Pieter Leyssen, Susan Obeid, David Durantel, Fabien Zoulim, Anne Op de Beeck, Johan Neyts – 23 June 2009 – Statins are 3‐hydroxyl‐3‐methylglutaryl coenzyme A (HMG CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It was recently reported that statins inhibit in vitro hepatitis C virus (HCV) RNA replication.

Hong‐Lei Weng, Yan Liu, Jia‐Lin Chen, Tong Huang, Li‐Jun Xu, Patricio Godoy, Jun‐Hua Hu, Cheng Zhou, Felix Stickel, Alexander Marx, Rainer M. Bohle, Vincent Zimmer, Frank Lammert, Sebastian Mueller, Michelle Gigou, Didier Samuel, Peter R. Mertens, Manfred V. Singer, Helmut K.

Shujuan Pan, Lu Huang, John McPherson, Donna Muzny, Farshid Rouhani, Mark Brantly, Richard Gibbs, Richard N. Sifers – 23 June 2009 – Inappropriate accumulation of the misfolded Z variant of alpha1‐antitrypsin in the hepatocyte endoplasmic reticulum (ER) is a risk factor for the development of end‐stage liver disease. However, the genetic and environmental factors that contribute to its etiology are poorly understood. ER mannosidase I (ERManI) is a quality control factor that plays a critical role in the sorting and targeting of misfolded glycoproteins for proteasome‐mediated degradation.

Lydia Lee, Mouhamad Alloosh, Romil Saxena, William Van Alstine, Bruce A. Watkins, James E. Klaunig, Michael Sturek, Naga Chalasani – 23 June 2009 – Miniature pigs residing in the Ossabaw Island (Ossabaw pigs) exhibit a thrifty genotype, and when fed a high‐calorie diet they consistently develop metabolic syndrome defined by obesity, insulin resistance, hypertension, and dyslipidemia. We conducted a study to induce steatohepatitis in Ossabaw pigs by dietary manipulation.

Alexander Weymann, Eric Hartman, Vered Gazit, Connie Wang, Martin Glauber, Yumirle Turmelle, David A. Rudnick – 23 June 2009 – The inhibitory effect of dextrose supplementation on liver regeneration was first described more than 4 decades ago. Nevertheless, the molecular mechanisms responsible for this observation have not been elucidated. We investigated these mechanisms using the partial hepatectomy model in mice given standard or 10% dextrose (D10)‐supplemented drinking water.

Stephen Harrison, Elizabeth Brunt, Brent Neuschwander‐Tetri – 23 June 2009

Teoman Dogru, Cemal Nuri Ercin, Serkan Tapan, Murat Kantarcioglu, Muammer Kara, Sait Bagci – 23 June 2009

Julien Calderaro, Elie Serge Zafrani – 23 June 2009

David van der Poorten, Kerry‐Lee Milner, Donald J. Chisholm, Jacob George – 23 June 2009