Evolution of hepatic steatosis in patients with advanced hepatitis C: Results from the hepatitis C antiviral long‐term treatment against cirrhosis (HALT‐C) trial

Anna S. Lok, James E. Everhart, Raymond T. Chung, Hae‐Young Kim, Gregory T. Everson, John C. Hoefs, Joel K. Greenson, Richard K. Sterling, Karen L. Lindsay, William M. Lee, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Marc G. Ghany, Chihiro Morishima, HALT‐C Trial Group – 28 May 2009 – Hepatic steatosis is a common histologic feature in patients with chronic hepatitis C (CHC) but there are no large longitudinal studies describing the progression of steatosis in CHC.

Safety of invasive procedures in end‐stage liver disease patients

James D. Perkins – 28 May 2009 – Patients with end‐stage liver disease (ESLD) are predisposed to bleeding complications due to thrombocytopenia, reduced synthesis of coagulation factors, and increased fibrinolytic activity. The exact incidence of vascular access site and bleeding complications related to cardiac catheterization in this group remains unknown. Eighty‐eight consecutive patients with ESLD who underwent left‐sided cardiac catheterization from August 2004 to February 2007 were identified.

Smoking behavior in liver transplant recipients

Frans van der Heide, Gerard Dijkstra, Robert J. Porte, Jan H. Kleibeuker, Elizabeth B. Haagsma – 28 May 2009 – Long‐term morbidity and survival after orthotopic liver transplantation (OLT) are to a large degree determined by cardiovascular disease and cancer. Tobacco use is a well‐known risk factor for both. The aim of this study was to examine smoking behavior before and after OLT and to define groups at risk for resuming tobacco use after OLT. In addition, we looked for a relation between smoking and morbidity after OLT.

Impact of the donor risk index on the outcome of hepatitis C virus–positive liver transplant recipients

Daniel G. Maluf, Erick B. Edwards, R. Todd Stravitz, H. Myron Kauffman – 28 May 2009 – We have investigated the impact of the donor risk index (DRI) on the outcome of hepatitis C virus (HCV)–infected patients undergoing liver transplantation (LTx). Retrospective analysis was performed from the Organ Procurement and Transplantation Network database (January 1, 2000 to June, 2006). The DRI was calculated as described by Feng et al. (Am J Transplant 2006;6:783–790). Model for End‐Stage Liver Disease (MELD) exceptions were excluded from the analysis.

Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease

Kerry‐Lee Milner, David van der Poorten, Aimin Xu, Elisabetta Bugianesi, James G. Kench, Karen S. L. Lam, Donald J. Chisholm, Jacob George – 28 May 2009 – Several circulating cytokines are increased with obesity and may combine with the influence of visceral fat to generate insulin resistance, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).

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