Apolipoprotein B100 acts as a molecular link between lipid‐induced endoplasmic reticulum stress and hepatic insulin resistance

Qiaozhu Su, Julie Tsai, Elaine Xu, Wei Qiu, Erika Bereczki, Miklos Santha, Khosrow Adeli – 23 June 2009 – Accumulation of unfolded and misfolded proteins in the endoplasmic reticulum (ER) results in ER stress and lipid overload‐induced ER stress has been implicated in the development of insulin resistance. Here, evidence is provided for a molecular link between hepatic apolipoprotein B100 (apoB100), induction of ER stress, and attenuated insulin signaling.

Bile salt–phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent

Walee Chamulitrat, Jürgen Burhenne, Tobias Rehlen, Anita Pathil, Wolfgang Stremmel – 23 June 2009 – A decrease of hepatocellular phosphatidylcholine (PC) is associated with hepatic injury, e.g., in nonalcoholic steatohepatitis (NASH). Therefore, we evaluated the hepatoprotective effect of a PC‐precursor lipid specifically targeted to the liver. We synthesized the bile acid‐phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA‐LPE), which was designed to target PC to hepatocytes by way of bile‐acid transport systems.

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